Full Table of ContentsIssue Highlights
- miR-143, miR-222, and miR-452 Are Useful as Tumor Stratification and Noninvasive Diagnostic Biomarkers for Bladder Cancer
Tumor miRNA expression in bladder cancer correlates with tumor grade, recurrence, progression, and survival. Furthermore, noninvasive detection of miR-452 and miR-222 in urine provides high accuracies for bladder cancer diagnosis.
- Focal Immune-Mediated White Matter Demyelination Reveals an Age-Associated Increase in Axonal Vulnerability and Decreased Remyelination Efficiency
In a model of focal immune-mediated demyelinating injury, aged adult mice exhibit increased vulnerability to axonal injury and reduced efficiency of remyelination compared to young animals, with remyelination in aged mice predominantly Schwann cell mediated versus central oligodendrocyte mediated in younger animals.
- Promotion of a Functional B-Cell Germinal Center Response after Leishmania spp. Co-Infection Is Associated with Lesion Resolution
Outcomes differ in C3HeB/FeJ (C3H) versus C57Bl/6 (B6) mice co-infected with both Leishmania major and L. amazonensis. New data establish a fundamental difference in the immune response to Leishmania infection, namely presence/absence of productive B-cell germinal center response.
- The F508del Mutation in Cystic Fibrosis Transmembrane Conductance Regulator Gene Impacts Bone Formation
CFTR F508del mice exhibit reduced bone mineral density, lower femoral bone mass, and altered trabecular bone architecture, as well as decreased bone formation rate, compared to controls, providing a valuable tool to examine emerging targets for the treatment of cystic fibrosis-related bone disease.
- The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma
An analysis of glioblastoma samples from the Cancer Genome Atlas questions the current transcriptional classification system as the mesenchymal class is enriched with samples with a high degree of necrosis and non-mesenchymal glioblastomas become more similar to the mesenchymal class with increasing levels of necrosis.
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Innate Imprinting of Murine Resident Alveolar Macrophages by Allergic Bronchial Inflammation Causes a Switch from Hypo- to Hyperinflammatory Reactivity21 May 2012
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Contribution of NK Cells to the Innate Phase of Host Protection Against an Intracellular Bacterium Targeting Systemic Endothelium21 May 2012
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Contribution of Stem Cells to Neointimal Formation of Decellularized Vessel Grafts in a Novel Mouse Model21 May 2012
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The Regulatory Roles of Apoptosis-Inducing Factor in the Formation and Regression Processes of Ocular Neovascularization21 May 2012
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Overexpression of IFITM1 Has Clinicopathologic Effects on Gastric Cancer and Is Regulated by an Epigenetic Mechanism21 May 2012
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