Current Issue May 2012 | Vol.180 No. 5

Tumor miRNA expression in bladder cancer correlates with tumor grade, recurrence, progression, and survival. Furthermore, noninvasive detection of miR-452 and miR-222 in urine provides high accuracies for bladder cancer diagnosis.

In a model of focal immune-mediated demyelinating injury, aged adult mice exhibit increased vulnerability to axonal injury and reduced efficiency of remyelination compared to young animals, with remyelination in aged mice predominantly Schwann cell mediated versus central oligodendrocyte mediated in younger animals.

Outcomes differ in C3HeB/FeJ (C3H) versus C57Bl/6 (B6) mice co-infected with both Leishmania major and L. amazonensis. New data establish a fundamental difference in the immune response to Leishmania infection, namely presence/absence of productive B-cell germinal center response.

CFTR F508del mice exhibit reduced bone mineral density, lower femoral bone mass, and altered trabecular bone architecture, as well as decreased bone formation rate, compared to controls, providing a valuable tool to examine emerging targets for the treatment of cystic fibrosis-related bone disease.

An analysis of glioblastoma samples from the Cancer Genome Atlas questions the current transcriptional classification system as the mesenchymal class is enriched with samples with a high degree of necrosis and non-mesenchymal glioblastomas become more similar to the mesenchymal class with increasing levels of necrosis.