Current Issue March 2012 | Vol.180 No. 3
Issue Highlights
- Inflammation-Induced Lymph Node Lymphangiogenesis Is Reversible
The detection of residual inflammation-induced lymph node lymphangiogenesis might hamper identification of metastasized lymph nodes. A technique termed anti-LYVE-1 immuno-PET reveals that the lymphatic network regresses following resolution of inflammation. This technique might be a promising strategy for the early detection of cancer metastasis.
- The NF-κB Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis
NF-κB activity is increased in the diseased heart. Mice deficient in the NF-κB subunit c-Rel have smaller hearts and are protected from developing cardiac hypertrophy and fibrosis after chronic angiotensin infusion. c-Rel-dependent signaling is critical for both cardiac remodeling and hypertrophy, and targeting its activities could offer novel therapeutic strategies.
- Cathepsin Cleavage of Sirtuin-1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence
Stress-induced premature senescence (SIPS) contributes to global endothelial cell dysfunction, including lysosomal dysfunction. The effects of stressors could be partially mimicked by inducing lysosomal membrane permeabilization or inhibiting autophagy and are reversed by a cathepsin inhibitor. The cathepsin substrate sirtuin 1 (SIRT1) plays an important role, linking cell stress to apoptosis and SIPS.
- Neural Stem Cell Depletion and CNS Developmental Defects After Enteroviral Infection
The cytolytic virus coxsackievirus B3 (CVB3) can persist within the neonatal central nervous system (CNS) and target neural stem cells. Long-term neurological sequelae can occur after neonatal enteroviral infections, yet antiviral treatment initiated long after the end of acute infection might limit virus-mediated neuropathology.
- Heterogeneity of Tumor Endothelial Cells: Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic Tumors
Tumor endothelial cells (TECs) differ from normal endothelial cells, and TECs from high metastatic tumors have a more proangiogenic phenotype than those from low metastatic tumors. Further studies on TEC heterogeneity will facilitate the selection of suitable anti-angiogenic therapies.
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Villin Expression Is Frequently Lost in Poorly Differentiated Colon Cancer20 February 2012
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Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy20 February 2012
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Hedgehog-Gli Pathway Activation during Kidney Fibrosis20 February 2012
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Ferroxidase Hephaestin's Cell: Autonomous Role in the Retinal Pigment Epithelium20 February 2012
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In Vivo Characterization of Mutant Myotilins20 February 2012

Phagocytic Clearance in Neurodegeneration



