The American Journal of Pathology
Volume 180, Issue 3 , Pages 963-972 , March 2012

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

  • Utano Tomaru

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • Corresponding Author InformationAddress reprint requests to Utano Tomaru, M.D., Ph.D., Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan
    • ,
  • Satomi Takahashi

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Akihiro Ishizu

      Affiliations

    • Faculty of Health Sciences, Hokkaido University, Sapporo, Japan
    • ,
  • Yukiko Miyatake

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Aya Gohda

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Sayuri Suzuki

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Ayako Ono

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Jiro Ohara

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Tomohisa Baba

      Affiliations

    • Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    • ,
  • Shigeo Murata

      Affiliations

    • Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan
    • ,
  • Keiji Tanaka

      Affiliations

    • Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
    • ,
  • Masanori Kasahara

      Affiliations

    • Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

,Accepted 4 November 2011.

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 Supported in part by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (U.T.).

 Supplemental material for this article can be found at http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.11.012.

PII: S0002-9440(11)01075-3

doi: 10.1016/j.ajpath.2011.11.012

The American Journal of Pathology
Volume 180, Issue 3 , Pages 963-972 , March 2012

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