The American Journal of Pathology
Volume 180, Issue 3 , Pages 1080-1094 , March 2012

Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets

  • Matthew B. Greenblatt

      Affiliations

    • Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Jennifer L. Sargent

      Affiliations

    • Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire
    • ,
  • Giuseppina Farina

      Affiliations

    • Division of Rheumatology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
    • ,
  • Kelly Tsang

      Affiliations

    • Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    • ,
  • Robert Lafyatis

      Affiliations

    • Division of Rheumatology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts
    • ,
  • Laurie H. Glimcher

      Affiliations

    • Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    • Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Ragon Institute, Massachusetts General Hospital, Harvard University, and Massachusetts Institute of Technology, Boston, Massachusetts
    • ,
  • Michael L. Whitfield

      Affiliations

    • Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire
    • Corresponding Author InformationAddress reprint requests to Antonios O. Aliprantis, M.D., Ph.D., Harvard School of Public Health, 651 Huntington Ave, FXB 205, Boston, MA 02115, or to Michael L. Whitfield, Ph.D., Department of Genetics, Dartmouth Medical School, 7400 Remsen, Hanover, NH 03755
    • ,
  • Antonios O. Aliprantis

      Affiliations

    • Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts
    • Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
    • Corresponding Author InformationAddress reprint requests to Antonios O. Aliprantis, M.D., Ph.D., Harvard School of Public Health, 651 Huntington Ave, FXB 205, Boston, MA 02115, or to Michael L. Whitfield, Ph.D., Department of Genetics, Dartmouth Medical School, 7400 Remsen, Hanover, NH 03755

,Accepted 17 November 2011.

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 Supported by grants from the Scleroderma Research Foundation (M.L.W., A.O.A. and L.H.G.), a Hulda Irene Duggan Arthritis Investigator Award from the Arthritis Foundation (M.L.W.), a Career Award for Medical Scientists from the Burroughs Wellcome Fund (A.O.A.), by an NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases grant K08AR054859 (A.O.A), NIAMS grants U01AR055063 (R.L.) and R01AR051089 (R.L.), and by Scleroderma Foundation support (G.F.).

 M.B.G. and J.L.S. contributed equally to the present work.

 Disclosures: L.H.G. is a member of the board of directors of and holds equity in Bristol Myers Squibb and receives research funds from Merck & Co. M.L.W. is a scientific founder and holds a financial interest in Celdara Medical, LLC. The other authors declare no conflicts of interest.

 The content of this manuscript is solely the responsibility of the authors and does not represent the official views of NIAMS or the NIH.

 Supplemental material for this article can be found at http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.11.024.

 Current address of J.L.S., NIH-NIAMS, Bethesda, Maryland; of L.H.G., Weill Cornell Medical College, New York, New York.

PII: S0002-9440(11)01088-1

doi: 10.1016/j.ajpath.2011.11.024

The American Journal of Pathology
Volume 180, Issue 3 , Pages 1080-1094 , March 2012

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