The American Journal of Pathology
Volume 180, Issue 3 , Pages 1283-1293 , March 2012

Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment

  • Kosuke Akiyama

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • Department of Gerodontology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Noritaka Ohga

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Yasuhiro Hida

      Affiliations

    • Department of Surgical Oncology, Graduate School of Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Taisuke Kawamoto

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Yoshihiro Sadamoto

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Shuhei Ishikawa

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Nako Maishi

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Tomoshige Akino

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • Department of Renal and Genitourinary Surgery, Graduate School of Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Miyako Kondoh

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Aya Matsuda

      Affiliations

    • Department of Oral Pathology and Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Nobuo Inoue

      Affiliations

    • Department of Gerodontology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Masanobu Shindoh

      Affiliations

    • Department of Oral Pathology and Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • ,
  • Kyoko Hida

      Affiliations

    • Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, Hokkaido, Japan
    • Corresponding Author InformationAddress reprint requests to Kyoko Hida, D.D.S., Ph.D., Department of Vascular Biology, Graduate School of Dental Medicine, University of Hokkaido, N13 W7, Kita-ku, Sapporo 060-8586, Hokkaido, Japan

,Accepted 17 November 2011.

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 Supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan (20390506 and 21659458 to K.H.) and the Akiyama Foundation (K.H.).

 Supplemental material for this article can be found at http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.11.029.

PII: S0002-9440(11)01097-2

doi: 10.1016/j.ajpath.2011.11.029

The American Journal of Pathology
Volume 180, Issue 3 , Pages 1283-1293 , March 2012

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