The American Journal of Pathology
Volume 180, Issue 3 , Pages 895-903 , March 2012

Integrative Molecular Profiling Reveals Asparagine Synthetase Is a Target in Castration-Resistant Prostate Cancer

  • Kanishka Sircar

      Affiliations

    • Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • Corresponding Author InformationAddress reprint requests to Kanishka Sircar, M.D., or Wei Zhang, Ph.D., Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030
    • ,
  • Heng Huang

      Affiliations

    • Department of Computer Science and Engineering, The University of Texas Arlington, Arlington, Texas
    • ,
  • Limei Hu

      Affiliations

    • Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • David Cogdell

      Affiliations

    • Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Jasreman Dhillon

      Affiliations

    • Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Vassiliki Tzelepi

      Affiliations

    • Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Eleni Efstathiou

      Affiliations

    • Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Ismaël H. Koumakpayi

      Affiliations

    • Research Center, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Fred Saad

      Affiliations

    • Research Center, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Dijun Luo

      Affiliations

    • Department of Computer Science and Engineering, The University of Texas Arlington, Arlington, Texas
    • ,
  • Tarek A. Bismar

      Affiliations

    • Department of Pathology, University of Calgary, Calgary, Alberta, Canada
    • ,
  • Ana Aparicio

      Affiliations

    • Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Patricia Troncoso

      Affiliations

    • Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Nora Navone

      Affiliations

    • Department of Genitourinary Medical Oncology and the David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas M.D. Anderson Cancer Center, Houston, Texas
    • ,
  • Wei Zhang

      Affiliations

    • Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas

,Accepted 11 November 2011.

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 Supported in part by institutional funds from the M.D. Anderson Cancer Center (K.S.). Proteomic data were generated using the Biospecimen Extraction and RPPA core facilities at the M.D. Anderson Cancer Center. These facilities are funded by a grant from the National Cancer Institute (CA 16672).

 Author Contributions: K.S., H.H., P.T., N.N., and W.Z. conceived the experiments and analyzed data; K.S., J.D., V.T., E.E., I.H.K., F.S., T.A.B., and A.A. were involved in study design and data collection; and L.H., D.C., J.D., and D.L. performed the experiments. All authors were involved in writing the article and had final approval of the submitted and published versions.

 Supplemental material for this article can be found at http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.11.030.

PII: S0002-9440(11)01098-4

doi: 10.1016/j.ajpath.2011.11.030

The American Journal of Pathology
Volume 180, Issue 3 , Pages 895-903 , March 2012

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