The American Journal of Pathology
Volume 180, Issue 4 , Pages 1495-1508 , April 2012

Gene Deletions and Amplifications in Human Hepatocellular Carcinomas: Correlation with Hepatocyte Growth Regulation

  • Michael A. Nalesnik

      Affiliations

    • Department of Pathology, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • ,
  • George Tseng

      Affiliations

    • Departments of Biostatistics, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • ,
  • Ying Ding

      Affiliations

    • Departments of Biostatistics, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
    • Department of Surgery, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • ,
  • Guo-Sheng Xiang

      Affiliations

    • Department of Pathology, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • ,
  • Zhong-liang Zheng

      Affiliations

    • Department of Pathology, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • ,
  • YanPing Yu

      Affiliations

    • Department of Pathology, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • ,
  • James W. Marsh

      Affiliations

    • Joint CMU-Pitt Ph.D. Program in Computational Biology, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • ,
  • George K. Michalopoulos

      Affiliations

    • Department of Pathology, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
    • Corresponding Author InformationAddress reprint requests to George K. Michalopoulos, M.D., Ph.D., S410 BST, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15241
  • ,
  • Jian-Hua Luo

      Affiliations

    • Department of Pathology, the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

,Accepted 22 December 2011.

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 Supported by the Rangos Fund for Enhancement of Pathology Research (RSG-08-137-01-CNE to Y.P.Y.) and grants from the NIH (5R01CA103958-05 and 5R01CA035373-27 to G.K.M. and R01CA098249 to J.-H.L.).

 M.A.N. and G.T. contributed equally to this work.

 Supplemental material for this article can be found on http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.12.021.

PII: S0002-9440(12)00024-7

doi: 10.1016/j.ajpath.2011.12.021

The American Journal of Pathology
Volume 180, Issue 4 , Pages 1495-1508 , April 2012