The American Journal of Pathology
Volume 180, Issue 4 , Pages 1398-1412 , April 2012

STAT3-Mediated Signaling Dysregulates Lung Fibroblast-Myofibroblast Activation and Differentiation in UIP/IPF

  • Dmitri V. Pechkovsky

      Affiliations

    • UBC James Hogg Research Centre, Institute for Heart + Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada
    • Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    • Corresponding Author InformationAddress reprint requests to Dmitri V. Pechovsky, M.D., Ph.D. or Darryl A. Knight, Ph.D., UBC James, Hogg iCAPTURE Centre, Room 166, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC V6Z 1Y6, Canada
    • ,
  • Cecilia M. Prêle

      Affiliations

    • Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, Department of Medicine, University of Western Australia, Perth, Australia
    • ,
  • John Wong

      Affiliations

    • UBC James Hogg Research Centre, Institute for Heart + Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada
    • ,
  • Cory M. Hogaboam

      Affiliations

    • Immunology Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan
    • ,
  • Robin J. McAnulty

      Affiliations

    • Centre for Respiratory Research, Division of Medicine, University College London, London, United Kingdom
    • ,
  • Geoffrey J. Laurent

      Affiliations

    • Centre for Respiratory Research, Division of Medicine, University College London, London, United Kingdom
    • ,
  • Samuel S.-M. Zhang

      Affiliations

    • Department of Neural and Behavioral Sciences, Penn State University College of Medicine, Hershey, Pennsylvania
    • ,
  • Moisés Selman

      Affiliations

    • National Institute of Respiratory Diseases, Mexico City, Mexico
    • ,
  • Steven E. Mutsaers

      Affiliations

    • Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, Department of Medicine, University of Western Australia, Perth, Australia
    • ,
  • Darryl A. Knight

      Affiliations

    • UBC James Hogg Research Centre, Institute for Heart + Lung Health, St. Paul's Hospital, Vancouver, British Columbia, Canada
    • Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
    • Corresponding Author InformationAddress reprint requests to Dmitri V. Pechovsky, M.D., Ph.D. or Darryl A. Knight, Ph.D., UBC James, Hogg iCAPTURE Centre, Room 166, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC V6Z 1Y6, Canada

,Accepted 6 December 2011.

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 Supported by Canadian Institutes for Health Research (MOP-97993), the British Columbia Lung Association, the Wolfe and Gita Churg Foundation, the Rashpal Dhillon endowment for IPF Research, and the National Health and Medical Research Council of Australia (project grant 303137). D.A.K. is the Canada Research Chair in Airway Disease and is a Career Investigator at the Michael Smith Foundation for Health Research.

 Supplemental material for this article can be found at http://ajp.amjpathol.org and at doi: 10.1016/j.ajpath.2011.12.022.

PII: S0002-9440(12)00025-9

doi: 10.1016/j.ajpath.2011.12.022

The American Journal of Pathology
Volume 180, Issue 4 , Pages 1398-1412 , April 2012

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