The American Journal of Pathology
Volume 180, Issue 4 , Pages 1751-1760 , April 2012

Macrophage β2 Integrin–Mediated, HuR-Dependent Stabilization of Angiogenic Factor–Encoding mRNAs in Inflammatory Angiogenesis

  • Jiange Zhang

      Affiliations

    • Departments of Medicine (Cardiovascular Medicine) and Immunobiology and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University, New Haven, Connecticut
    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • ,
  • Yasha Modi

      Affiliations

    • Departments of Medicine (Cardiovascular Medicine) and Immunobiology and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University, New Haven, Connecticut
    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • ,
  • Timur Yarovinsky

      Affiliations

    • Departments of Medicine (Cardiovascular Medicine) and Immunobiology and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University, New Haven, Connecticut
    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • ,
  • Jun Yu

      Affiliations

    • Departments of Medicine (Cardiovascular Medicine) and Immunobiology and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University, New Haven, Connecticut
    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • ,
  • Mark Collinge

      Affiliations

    • Departments of Medicine (Cardiovascular Medicine) and Immunobiology and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University, New Haven, Connecticut
    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • ,
  • Themis Kyriakides

      Affiliations

    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • Department of Pathology, Yale University, New Haven, Connecticut
    • ,
  • Yizhun Zhu

      Affiliations

    • Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    • ,
  • William C. Sessa

      Affiliations

    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • Department of Pharmacology, Yale University, New Haven, Connecticut
    • ,
  • Ruggero Pardi

      Affiliations

    • Department of Molecular Pathology, Universita Vita Salute School of Medicine, San Raffaele Scientific Institute, Milan, Italy
    • ,
  • Jeffrey R. Bender

      Affiliations

    • Departments of Medicine (Cardiovascular Medicine) and Immunobiology and the Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Yale University, New Haven, Connecticut
    • Vascular Biology and Therapeutics Program, Yale University, New Haven, Connecticut
    • Corresponding Author InformationAddress reprint requests to Jeffrey R. Bender, M.D., Yale University, 300 George St., 773G, New Haven, CT 06511

,Accepted 9 December 2011.

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 Supported by NIH grant HL 43331 and a Raymond and Beverly Sackler Foundation award (J.R.B.), by grants from Associazone Italiana per la Ricerca sul Cancro and Telethon (R.P.), and by American Heart Association grant SDG 0930157N (J.Y).

 Supplemental material for this article can be found on http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.12.025.

PII: S0002-9440(12)00028-4

doi: 10.1016/j.ajpath.2011.12.025

The American Journal of Pathology
Volume 180, Issue 4 , Pages 1751-1760 , April 2012

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