The American Journal of Pathology
Volume 180, Issue 4 , Pages 1663-1674 , April 2012

Transforming Growth Factor Beta-Induced (TGFBI) Is an Anti-Adhesive Protein Regulating the Invasive Growth of Melanoma Cells

  • Pirjo Nummela

      Affiliations

    • Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Johanna Lammi

      Affiliations

    • Research Programs Unit, Molecular Cancer Biology and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    • ,
  • Johanna Soikkeli

      Affiliations

    • Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Olli Saksela

      Affiliations

    • Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Pirjo Laakkonen

      Affiliations

    • Research Programs Unit, Molecular Cancer Biology and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    • Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland
    • ,
  • Erkki Hölttä

      Affiliations

    • Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    • Corresponding Author InformationAddress reprint requests to Erkki Hölttä, M.D., Ph.D., Department of Pathology, Haartman Institute, P.O. Box 21 (Haartmaninkatu 3), FI-00014 Helsinki, Finland

,Accepted 9 December 2011.

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 Supported by the Academy of Finland (E.H. and P.L.), the Finnish Cancer Organizations (E.H., P.L., and P.N.), Helsinki University Central Hospital Research Funds (Departments of Dermatology and HUSLAB) (O.S. and E.H.), the European Community's Seventh Framework Programme FP7/2007-2011 under grant agreement n°201279 (P.L.), and Maud Kuistila Memorial Foundation, Ida Montin Foundation, Paulo Foundation, and Biomedicum Helsinki Foundation (P.N.). J.S. is a pre-doctoral fellow of the Helsinki Graduate Program in Biotechnology and Molecular Biology.

 Supplemental material for this article can be found at http://ajp.amjapthol.org or at doi:10.1016/j.ajpath.2011.12.035.

PII: S0002-9440(12)00041-7

doi: 10.1016/j.ajpath.2011.12.035

The American Journal of Pathology
Volume 180, Issue 4 , Pages 1663-1674 , April 2012

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