The American Journal of Pathology
Volume 180, Issue 4 , Pages 1522-1534 , April 2012

Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A Streptococcus

  • Nahuel Fittipaldi

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Stephen B. Beres

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Randall J. Olsen

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Vivek Kapur

      Affiliations

    • Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania
    • ,
  • Patrick R. Shea

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • M. Ebru Watkins

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Concepcion C. Cantu

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Daniel R. Laucirica

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Leslie Jenkins

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Anthony R. Flores

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • ,
  • Marguerite Lovgren

      Affiliations

    • National Centre for Streptococcus and Provincial Laboratory for Public Health, Edmonton, Alberta, Canada
    • ,
  • Carmen Ardanuy

      Affiliations

    • Microbiology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    • ,
  • Josefina Liñares

      Affiliations

    • Microbiology Department, Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Barcelona, Spain
    • ,
  • Donald E. Low

      Affiliations

    • Ontario Agency for Health Protection and Promotion and University of Toronto, Toronto, Ontario, Canada
    • ,
  • Gregory J. Tyrrell

      Affiliations

    • National Centre for Streptococcus and Provincial Laboratory for Public Health, Edmonton, Alberta, Canada
    • ,
  • James M. Musser

      Affiliations

    • Department of Pathology and Genomic Medicine, and the Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital System, Houston, Texas
    • Corresponding Author InformationAddress reprint requests to James M. Musser, M.D., Ph.D., Department of Pathology and Genomic Medicine, The Methodist Hospital System, 6565 Fannin St., Houston, TX 77030

,Accepted 2 December 2011.

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 Supported by The Methodist Hospital System (Houston, TX) and the Canadian Institutes of Health Research (N.F.).

 CME Disclosure: None of the authors disclosed any relevant financial relationships.

 Supplemental material for this article can be found at http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.12.037.

PII: S0002-9440(12)00043-0

doi: 10.1016/j.ajpath.2011.12.037

The American Journal of Pathology
Volume 180, Issue 4 , Pages 1522-1534 , April 2012

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