The American Journal of Pathology
Volume 180, Issue 4 , Pages 1441-1453 , April 2012

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

  • Steven L. Fabian

      Affiliations

    • Renal Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • Radostin R. Penchev

      Affiliations

    • Renal Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • Benoit St-Jacques

      Affiliations

    • Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Anjali N. Rao

      Affiliations

    • Renal Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • ,
  • Petra Sipilä

      Affiliations

    • Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    • ,
  • Kip A. West

      Affiliations

    • Infinity Pharmaceuticals, Cambridge, Massachusetts
    • ,
  • Andrew P. McMahon

      Affiliations

    • Harvard Stem Cell Institute, Holyoke Center, Cambridge, Massachusetts
    • Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts
    • Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts
    • ,
  • Benjamin D. Humphreys

      Affiliations

    • Renal Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts
    • Harvard Stem Cell Institute, Holyoke Center, Cambridge, Massachusetts
    • Corresponding Author InformationAddress reprint requests to Benjamin D. Humphreys, M.D., Ph.D., Harvard Institutes of Medicine Room 554, 4 Blackfan Circle, Boston, MA 02115

,Accepted 29 December 2011.

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 Supported by the NIH (RO1 DK088923 to B.D.H. and T32 training grant DK007527 to S.L.F) and the Harvard Stem Cell Institute (B.D.H).

 Disclosures: K.A.W. holds stock options or bond holdings in a for-profit corporation or self-directed pension plan (Infinity Pharmaceuticals) and is also a full-time employee of Infinity Pharmaceuticals. None of the other authors disclosed any conflict of interest.

 Supplemental material for this article can be found on http://ajp.amjpathol.org or at doi: 10.1016/j.ajpath.2011.12.039.

PII: S0002-9440(12)00087-9

doi: 10.1016/j.ajpath.2011.12.039

The American Journal of Pathology
Volume 180, Issue 4 , Pages 1441-1453 , April 2012

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