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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Villin Expression Is Frequently Lost in Poorly Differentiated Colon Cancer
DOI: 10.1016/j.ajpath.2012.01.006
Colorectal cancers (CRCs) are classified as having microsatellite instability (MSI) or chromosomal instability (CIN); herein termed microsatellite stable (MSS). MSI colon cancers frequently display a ...
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Diego Arango,
Sheren Al-Obaidi,
David S. Williams,
Higinio Dopeso,
Rocco Mazzolini,
Georgia Corner,
Do-Sun Byun,
Azadeh A. Carr,
Carmel Murone,
Lars Tögel,
Nikolajs Zeps,
Lauri A. Aaltonen,
Barry Iacopetta,
John M. Mariadason
et al.
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Full-length article
(In Press Uncorrected Proof)
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20 February 2012 |
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Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy
DOI: 10.1016/j.ajpath.2011.12.033
Because retinal ischemia is a common cause of vision loss, we sought to determine the effects of ischemia on neuroretinal function and survival in murine oxygen-induced retinopathy (OIR) and to define...
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Freya M. Mowat,
Francisco Gonzalez,
Ulrich F.O. Luhmann,
Clemens Lange,
Yanai Duran,
Alexander J. Smith,
Patrick H. Maxwell,
Robin R. Ali,
James W.B. Bainbridge
et al.
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Full-length article
(In Press Uncorrected Proof)
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20 February 2012 |
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Hedgehog-Gli Pathway Activation during Kidney Fibrosis
DOI: 10.1016/j.ajpath.2011.12.039
The Hedgehog (Hh) signaling pathway regulates tissue patterning during development, including patterning and growth of limbs and face, but whether Hh signaling plays a role in adult kidney remains und...
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Steven L. Fabian,
Radostin R. Penchev,
Benoit St. Jacques,
Anjali N. Rao,
Petra Sipilä,
Kip A. West,
Andrew P. McMahon,
Benjamin D. Humphreys
et al.
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Full-length article
(In Press Uncorrected Proof)
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20 February 2012 |
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Ferroxidase Hephaestin's Cell: Autonomous Role in the Retinal Pigment Epithelium
DOI: 10.1016/j.ajpath.2011.12.041
Hephaestin (Heph) is a ferroxidase protein that converts ferrous to ferric iron to facilitate cellular iron export by ferroportin. Many tissues express either Heph or its homologue, ceruloplasmin (Cp)...
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Natalie Wolkow,
Delu Song,
Ying Song,
Sally Chu,
Majda Hadziahmetovic,
Jennifer C. Lee,
Jared Iacovelli,
Steven Grieco,
Joshua L. Dunaief
et al.
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Full-length article
(In Press Uncorrected Proof)
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20 February 2012 |
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In Vivo Characterization of Mutant Myotilins
DOI: 10.1016/j.ajpath.2011.12.040
Myofibrillar myopathy (MFM) is a group of disorders that are pathologically defined by the disorganization of the myofibrillar alignment associated with the intracellular accumulation of Z-disk-relate...
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Etsuko Keduka,
Yukiko K. Hayashi,
Sherine Shalaby,
Hiroaki Mitsuhashi,
Satoru Noguchi,
Ikuya Nonaka,
Ichizo Nishino
et al.
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Full-length article
(In Press Uncorrected Proof)
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20 February 2012 |
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Role of the Nuclear Receptor Coactivator AIB1/SRC-3 in Angiogenesis and Wound Healing
DOI: 10.1016/j.ajpath.2011.12.032
The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC-3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its...
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Maram Al-Otaiby,
Elena Tassi,
Marcel O. Schmidt,
Chris D. Chien,
Tabari Baker,
Armando Ganoza Salas,
Jianming Xu,
Mary Furlong,
Richard Schlegel,
Anna T. Riegel,
Anton Wellstein
et al.
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Full-length article
(In Press Uncorrected Proof)
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15 February 2012 |
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Identification of Three Novel Hearing Loss Mouse Strains with Mutations in the Tmc1 Gene
DOI: 10.1016/j.ajpath.2011.12.034
We report the identification of three new mouse models, baringo, nice, and stitch, with recessively inherited sensorineural deafness due to novel mutations in the transmembrane channel-like gene 1 (Tm...
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Shehnaaz S.M. Manji,
Kerry A. Miller,
Louise H. Williams,
Hans-Henrik M. Dahl
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Full-length article
(In Press Uncorrected Proof)
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13 February 2012 |
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DR3 Signaling Protects against Cisplatin Nephrotoxicity Mediated by Tumor Necrosis Factor
DOI: 10.1016/j.ajpath.2012.01.003
The expression of death receptor 3 (DR3), a member of the tumor necrosis factor (TNF) receptor superfamily, is up-regulated in human tubular epithelial cells (TECs) during renal injury, but its functi...
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Rafia S. Al-Lamki,
WanHua Lu,
Sarah Finlay,
Jason P. Twohig,
Eddie C.Y. Wang,
Aviva M. Tolkovsky,
John R. Bradley
et al.
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Full-length article
(In Press Uncorrected Proof)
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13 February 2012 |
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Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A Streptococcus
DOI: 10.1016/j.ajpath.2011.12.037
An epidemic of severe invasive human infections caused by type emm59 group A Streptococcus (GAS), heretofore an exceedingly rare cause of disease, spread west to east across Canada over a 3-year perio...
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Nahuel Fittipaldi,
Stephen B. Beres,
Randall J. Olsen,
Vivek Kapur,
Patrick R. Shea,
M. Ebru Watkins,
Concepcion C. Cantu,
Daniel R. Laucirica,
Leslie Jenkins,
Anthony R. Flores,
Marguerite Lovgren,
Carmen Ardanuy,
Josefina Liñares,
Donald E. Low,
Gregory J. Tyrrell,
James M. Musser
et al.
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Full-length article
(In Press Uncorrected Proof)
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13 February 2012 |
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S100P-Binding Protein, S100PBP, Mediates Adhesion through Regulation of Cathepsin Z in Pancreatic Cancer Cells
DOI: 10.1016/j.ajpath.2011.12.031
Several S100 proteins are up-regulated in pancreatic ductal adenocarcinoma (PDAC), the most significant being S100P. We previously reported on S100PBP, a binding partner of S100P, that shows no homolo...
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Kate E. Lines,
Claude Chelala,
Branko Dmitrovic,
Nilukshi Wijesuriya,
Hemant M. Kocher,
John F. Marshall,
Tatjana Crnogorac-Jurcevic
et al.
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Full-length article
(In Press Uncorrected Proof)
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13 February 2012 |
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Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression
DOI: 10.1016/j.ajpath.2011.12.028
Pancreatic cancer is a significant cause of cancer mortality worldwide as the disease has advanced significantly in patients before symptoms are evident. The signal transduction pathways that promote ...
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Kiran Mahajan,
Domenico Coppola,
Y. Ann Chen,
Weiwei Zhu,
Harshani R. Lawrence,
Nicholas J. Lawrence,
Nupam P. Mahajan
et al.
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Short communication
(In Press Uncorrected Proof)
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10 February 2012 |
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Atomic Identification of Fluorescent Q-Dots on Tau-Positive Fibrils in 3D-Reconstructed Pick Bodies
DOI: 10.1016/j.ajpath.2011.12.029
Pick body disease, characterized by the presence of Pick bodies, is distinguished from neurofibrillary tangles in Alzheimer disease on the basis of their smooth, spherical shape. Quantum dots (QDs) ar...
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Miho Uematsu,
Eijiro Adachi,
Ayako Nakamura,
Kuniaki Tsuchiya,
Toshiki Uchihara
et al.
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Short communication
(In Press Uncorrected Proof)
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10 February 2012 |
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Pleiotropic Action of Renal Cell Carcinoma-Dysregulated miRNAs on Hypoxia-Related Signaling Pathways
DOI: 10.1016/j.ajpath.2011.12.030
The von Hippel-Lindau (VHL) gene is lost in ∼70% of all renal cell carcinomas (RCCs); however, increasing evidence supports the involvement of alternative mechanisms in the regulation of VHL expressio...
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Zsuzsanna Lichner,
Salvador Mejia-Guerrero,
Monika Ignacak,
Adriana Krizova,
Tian Tian Bao,
Andrew Hany Fathy Girgis,
Youssef Maged Youssef,
George Makram Yousef
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Altered Angiogenesis in Caveolin-1 Gene–Deficient Mice Is Restored by Ablation of Endothelial Nitric Oxide Synthase
DOI: 10.1016/j.ajpath.2011.12.018
Caveolin-1 is an essential structural protein of caveolae, specialized plasma membrane organelles highly abundant in endothelial cells, where they regulate multiple functions including angiogenesis. C...
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Christudas Morais,
Quteba Ebrahem,
Bela Anand-Apte,
Marie-Odile Parat
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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The Gne M712T Mouse as a Model for Human Glomerulopathy
DOI: 10.1016/j.ajpath.2011.12.023
Pathological glomerular hyposialylation has been implicated in certain unexplained glomerulopathies, including minimal change nephrosis, membranous glomerulonephritis, and IgA nephropathy. We studied ...
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Sravan Kakani,
Tal Yardeni,
Justin Poling,
Carla Ciccone,
Terren Niethamer,
Enriko D. Klootwijk,
Irini Manoli,
Daniel Darvish,
Shelley Hoogstraten-Miller,
Patricia Zerfas,
E. Tian,
Kelly G. Ten Hagen,
Jeffrey B. Kopp,
William A. Gahl,
Marjan Huizing
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Laminin-111 Protein Therapy Reduces Muscle Pathology and Improves Viability of a Mouse Model of Merosin-Deficient Congenital Muscular Dystrophy
DOI: 10.1016/j.ajpath.2011.12.019
Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is a lethal muscle-wasting disease that is caused by mutations in the LAMA2 gene, resulting in the loss of laminin-α2 protein. MDC1A pat...
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Jachinta E. Rooney,
Jolie R. Knapp,
Bradley L. Hodges,
Ryan D. Wuebbles,
Dean J. Burkin
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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A Defect of the INK4-Cdk4 Checkpoint and Myc Collaborate in Blastoid Mantle Cell Lymphoma–Like Lymphoma Formation in Mice
DOI: 10.1016/j.ajpath.2012.01.004
Mantle cell lymphoma (MCL) is a B-cell malignancy characterized by a monoclonal proliferation of lymphocytes with the co-expression of CD5 and CD43, but not of CD23. Typical MCL is associated with ove...
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Christelle Vincent-Fabert,
Rémi Fiancette,
Pauline Rouaud,
Christel Baudet,
Véronique Truffinet,
Virginie Magnone,
Angélique Guillaudeau,
Michel Cogné,
Pierre Dubus,
Yves Denizot
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Rapid Histamine-Induced Neutrophil Recruitment Is Sphingosine Kinase-1 Dependent
DOI: 10.1016/j.ajpath.2011.12.024
Leukocyte recruitment to sites of inflammation is critical for the development of acute allergic responses. Rapid P-selectin up-regulation by endothelial cells is a key promoter of leukocyte infiltrat...
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Wai Y. Sun,
Latasha D. Abeynaike,
Samantha Escarbe,
Charles D. Smith,
Stuart M. Pitson,
Michael J. Hickey,
Claudine S. Bonder
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Overexpression of Tumor Necrosis Factor-α in the Lungs Alters Immune Response, Matrix Remodeling, and Repair and Maintenance Pathways
DOI: 10.1016/j.ajpath.2011.12.020
Increased production of tumor necrosis factor (TNF)-α and matrix metalloproteinases (MMPs) is a feature of inflammatory lung diseases, including emphysema and fibrosis, but the divergent pathological ...
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Errol M. Thomson,
Andrew Williams,
Carole L. Yauk,
Renaud Vincent
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Macrophage β2 Integrin–Mediated, HuR-Dependent Stabilization of Angiogenic Factor–Encoding mRNAs in Inflammatory Angiogenesis
DOI: 10.1016/j.ajpath.2011.12.025
HuR is a member of the Drosophila Elav protein family that binds mRNA degradation sequences and prevents RNase-mediated degradation. Such HuR-mediated mRNA stabilization, which is stimulated by integr...
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Jiange Zhang,
Yasha Modi,
Timur Yarovinsky,
Jun Yu,
Mark Collinge,
Themis Kyriakides,
Yizhun Zhu,
William C. Sessa,
Ruggero Pardi,
Jeffrey R. Bender
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Partial Loss of Epithelial Phenotype in Kindlin-1–Deficient Keratinocytes
DOI: 10.1016/j.ajpath.2012.01.005
Kindlin-1 is an adaptor protein that is expressed by most epithelial cells and has been implicated in integrin bidirectional signaling. Mutations in the gene encoding kindlin-1 are associated with Kin...
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Haiyan Qu,
Tingting Wen,
Monika Pesch,
Monique Aumailley
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Gene Deletions and Amplifications in Human Hepatocellular Carcinomas: Correlation with Hepatocyte Growth Regulation
DOI: 10.1016/j.ajpath.2011.12.021
Tissues from 98 human hepatocellular carcinomas (HCCs) obtained from hepatic resections were subjected to somatic copy number variation (CNV) analysis. Most of these HCCs were discovered in livers res...
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Michael A. Nalesnik,
George Tseng,
Ying Ding,
Guo-Sheng Xiang,
Zhong-liang Zheng,
YanPing Yu,
James W. Marsh,
George K. Michalopoulos,
Jian-Hua Luo
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Transforming Growth Factor Beta-Induced (TGFBI) Is an Anti-Adhesive Protein Regulating the Invasive Growth of Melanoma Cells
DOI: 10.1016/j.ajpath.2011.12.035
Melanoma is a malignancy characterized by high invasive/metastatic potential, with no efficient therapy after metastasis. Understanding the molecular mechanisms underlying the invasive/metastatic tend...
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Pirjo Nummela,
Johanna Lammi,
Johanna Soikkeli,
Olli Saksela,
Pirjo Laakkonen,
Erkki Hölttä
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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STAT3-Mediated Signaling Dysregulates Lung Fibroblast-Myofibroblast Activation and Differentiation in UIP/IPF
DOI: 10.1016/j.ajpath.2011.12.022
STAT3 is a latent transcription factor that plays a role in regulating fibroblast function in fibrotic lung diseases. To further understand the role of STAT3 in the phenotypic divergence and function ...
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Dmitri V. Pechkovsky,
Cecilia M. Prêle,
John Wong,
Cory M. Hogaboam,
Robin J. McAnulty,
Geoffrey J. Laurent,
Samuel S.-M. Zhang,
Moisés Selman,
Steven E. Mutsaers,
Darryl A. Knight
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Intestinal Mast Cell Levels Control Severity of Oral Antigen-Induced Anaphylaxis in Mice
DOI: 10.1016/j.ajpath.2011.12.036
Food-triggered anaphylaxis can encompass a variety of symptoms that affect multiple organ systems and can be life threatening. The molecular distinction between non–life-threatening and life-threateni...
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Richard Ahrens,
Heather Osterfeld,
David Wu,
Chun-Yu Chen,
Muthuvel Arumugam,
Katherine Groschwitz,
Richard Strait,
Yui-hsi Wang,
Fred D. Finkelman,
Simon P. Hogan
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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TWEAK in Inclusion-Body Myositis Muscle - Possible Pathogenic Role of a Cytokine Inhibiting Myogenesis
DOI: 10.1016/j.ajpath.2011.12.027
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 exert pleiotropic effects, including regulation of myogenesis. Sporadic inclusion-body myositis (IBM) is the most com...
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Roberta Morosetti,
Carla Gliubizzi,
Cristina Sancricca,
Aldobrando Broccolini,
Teresa Gidaro,
Matteo Lucchini,
Massimiliano Mirabella
et al.
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Full-length article
(In Press Uncorrected Proof)
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10 February 2012 |
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Dorsal Root Ganglia Damage in SIV-Infected Rhesus Macaques: An Animal Model of HIV-Induced Sensory Neuropathy
DOI: 10.1016/j.ajpath.2011.12.016
HIV-associated sensory neuropathy (HIV-SN) is currently the most common neurological complication of chronic HIV infection and continues to substantially affect patient quality of life. Mechanisms und...
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Tricia H. Burdo,
Krystyna Orzechowski,
Heather L. Knight,
Andrew D. Miller,
Kenneth Williams
et al.
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Short communication
(In Press Uncorrected Proof)
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10 February 2012 |
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Nitric Oxide–Releasing Nanoparticles Accelerate Wound Healing by Promoting Fibroblast Migration and Collagen Deposition
DOI: 10.1016/j.ajpath.2011.12.013
Wound healing is a complex process that involves coordinated interactions between diverse immunological and biological systems. Long-term wounds remain a challenging clinical problem, affecting approx...
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George Han,
Long N. Nguyen,
Chitralekha Macherla,
Joel M. Friedman,
Joshua D. Nosanchuk,
Luis R. Martinez
et al.
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Full-length article
(In Press Uncorrected Proof)
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06 February 2012 |
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Aberrant Stratifin Overexpression Is Regulated by Tumor-Associated CpG Demethylation in Lung Adenocarcinoma
DOI: 10.1016/j.ajpath.2011.12.014
We previously have shown the aberrant overexpression of stratifin (SFN, 14-3-3 ς) in lung adenocarcinoma. Although SFN is known to facilitate tumor cell proliferation, the mechanism that underlies its...
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Aya Shiba-Ishii,
Masayuki Noguchi
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Full-length article
(In Press Corrected Proof)
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06 February 2012 |
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ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and Platelets
DOI: 10.1016/j.ajpath.2011.12.026
Lymphatic vessels (LVs) are important structures for antigen presentation, for lipid metabolism, and as conduits for tumor metastases, but they have been difficult to visualize in vivo. Prox1 is a tra...
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Lucy A. Truman,
Kevin L. Bentley,
Elenoe C. Smith,
Stephanie A. Massaro,
David G. Gonzalez,
Ann M. Haberman,
Myriam Hill,
Dennis Jones,
Wang Min,
Diane S. Krause,
Nancy H. Ruddle
et al.
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Full-length article
(In Press Uncorrected Proof)
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06 February 2012 |
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Amyloid Precursor Protein Is a Biomarker for Transformed Human Pluripotent Stem Cells
DOI: 10.1016/j.ajpath.2011.12.015
Increasing evidence suggests an important function of the β-amyloid precursor protein (APP) in malignant disease in humans; however, the biological basis for this evidence is not well understood at pr...
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Vivek Venkataramani,
Knut Thiele,
Carl Ludwig Behnes,
Gerald G. Wulf,
Paul Thelen,
Lennart Opitz,
Gabriella Salinas-Riester,
Oliver Wirths,
Thomas A. Bayer,
Stefan Schweyer
et al.
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Full-length article
(In Press Uncorrected Proof)
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03 February 2012 |
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Negative Feedback Mechanisms Surpass the Effect of Intrinsic EGFR Activation during Skin Chemical Carcinogenesis
DOI: 10.1016/j.ajpath.2011.12.017
The negative feedback regulation of epidermal growth factor receptor (EGFR) and other tyrosine kinase receptors, including receptor dephosphorylation and endocytosis followed by degradation, is becomi...
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Maik Dahlhoff,
Christian Rose,
Martin Hrabé de Angelis,
Eckhard Wolf,
Marlon R. Schneider
et al.
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Short communication
(In Press Uncorrected Proof)
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02 February 2012 |
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Chemotherapy-Associated Angiogenesis in Neuroblastoma Tumors
DOI: 10.1016/j.ajpath.2011.12.011
The influences of cytotoxic drugs on endothelial cells remain incompletely understood. Herein, we examined the effects of chemotherapeutic agents in experimental angiogenesis models and analyzed vesse...
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Martin Michaelis,
Nora Hinsch,
U. Ruth Michaelis,
Florian Rothweiler,
Thorsten Simon,
Hans W. ilhelm Doerr,
Jaroslav Cinatl,
Jindrich Cinatl
et al.
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Short communication
(In Press Corrected Proof)
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30 January 2012 |