| This Month in AJP |
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This Month in AJP
24 January 2012
The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology.
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873
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| Short Communications |
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Inflammation-Induced Lymph Node Lymphangiogenesis Is Reversible
26 December 2011
The extent of lymph node metastasis is a prognostic indicator of disease progression in many malignancies. Current noninvasive imaging technologies for the clinical assessment of lymph node metastases...
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Viviane Mumprecht,
Filip Roudnicky,
Michael Detmar
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874-879
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Host-Derived TGFB1 Deficiency Suppresses Lesion Development in a Mouse Model of Endometriosis
03 January 2012
Transforming growth factor-β1 (TGFB1) is a multifunctional cytokine that is abundant in both endometriotic lesions and the peritoneal fluid in women with endometriosis. However, the role of TGFB1 in t...
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M. Louise Hull,
M. Zahied Johan,
Wendy L. Hodge,
Sarah A. Robertson,
Wendy V. Ingman
et al.
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880-887
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MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin
02 February 2012
Soluble endoglin is an anti-angiogenic protein that is released from the placenta and contributes to both maternal endothelial dysfunction and the clinical features of severe preeclampsia. The mechani...
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Tu'uhevaha J. Kaitu'u-Lino,
Kirsten R. Palmer,
Clare L. Whitehead,
Elizabeth Williams,
Martha Lappas,
Stephen Tong
et al.
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888-894
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| Regular Articles |
| Biomarkers, Genomics, Proteomics, and Gene Regulation |
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Integrative Molecular Profiling Reveals Asparagine Synthetase Is a Target in Castration-Resistant Prostate Cancer
13 January 2012
The identification of new and effective therapeutic targets for the lethal, castration-resistant stage of prostate cancer (CRPC) has been challenging because of both the paucity of adequate frozen tis...
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Kanishka Sircar,
Heng Huang,
Limei Hu,
David Cogdell,
Jasreman Dhillon,
Vassiliki Tzelepi,
Eleni Efstathiou,
Ismaël H. Koumakpayi,
Fred Saad,
Dijun Luo,
Tarek A. Bismar,
Ana Aparicio,
Patricia Troncoso,
Nora Navone,
Wei Zhang
et al.
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895-903
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TFF3 Is a Normal Breast Epithelial Protein and Is Associated with Differentiated Phenotype in Early Breast Cancer but Predisposes to Invasion and Metastasis in Advanced Disease
The trefoil protein TFF3 stimulates invasion and angiogenesis in vitro. To determine whether it has a role in breast tumor metastasis and angiogenesis, its levels were measured by immunohistochemistry...
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Ahmed R.H. Ahmed,
Andrew B. Griffiths,
Michael T. Tilby,
Bruce R. Westley,
Felicity E.B. May
et al.
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904-916
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Low-Level Expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas
09 January 2012
Small, noncoding microRNAs (miRNAs) have been shown to be abnormally expressed in every tumor type examined. We used comparisons of global miRNA expression profiles of head and neck squamous cell carc...
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Thomas Harris,
Lizandra Jimenez,
Nicole Kawachi,
Jian-Bing Fan,
Jing Chen,
Tom Belbin,
Andrew Ramnauth,
Olivier Loudig,
Christian E. Keller,
Richard Smith,
Michael B. Prystowsky,
Nicolas F. Schlecht,
Jeffrey E. Segall,
Geoffrey Childs
et al.
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917-928
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| Cardiovascular, Pulmonary, and Renal Pathology |
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The NF-κB Subunit c-Rel Stimulates Cardiac Hypertrophy and Fibrosis
03 January 2012
Cardiac remodeling and hypertrophy are the pathological consequences of cardiovascular disease and are correlated with its associated mortality. Activity of the transcription factor NF-κB is increased...
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Silvia Gaspar-Pereira,
Nicola Fullard,
Paul A. Townsend,
Paul S. Banks,
Elizabeth L. Ellis,
Christopher Fox,
Aidan G. Maxwell,
Lindsay B. Murphy,
Adam Kirk,
Ralf Bauer,
Jorge H. Caamaño,
Nichola Figg,
Roger S. Foo,
Jelena Mann,
Derek A. Mann,
Fiona Oakley
et al.
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929-939
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Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria
27 December 2011
The mechanism of proteinuria in many common kidney diseases involves glomerular hemodynamic effects and local expression of angiogenic, fibrogenic, and vasoactive factors. Transforming growth factor (...
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Ayesha Ghayur,
Limin Liu,
Martin Kolb,
Arun Chawla,
Shahid Lambe,
Anil Kapoor,
Peter J. Margetts
et al.
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940-951
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β1 Integrin Gene Excision in the Adult Murine Cardiac Myocyte Causes Defective Mechanical and Signaling Responses
16 January 2012
How mechanical signals are transmitted in the cardiac myocyte is poorly understood. In this study, we produced a tamoxifen-inducible mouse model in which β1 integrin could be reduced specifically in t...
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Ruixia Li,
Ying Wu,
Ana Maria Manso,
Yusu Gu,
Peter Liao,
Sharon Israeli,
Toshitaka Yajima,
Uyen Nguyen,
Michael S. Huang,
Nancy D. Dalton,
Kirk L. Peterson,
Robert S. Ross
et al.
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952-962
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| Cell Injury, Repair, Aging, and Apoptosis |
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Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities
03 January 2012
The proteasome is a multicatalytic enzyme complex responsible for the degradation of both normal and damaged proteins. An age-related decline in proteasomal activity has been implicated in various age...
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Utano Tomaru,
Satomi Takahashi,
Akihiro Ishizu,
Yukiko Miyatake,
Aya Gohda,
Sayuri Suzuki,
Ayako Ono,
Jiro Ohara,
Tomohisa Baba,
Shigeo Murata,
Keiji Tanaka,
Masanori Kasahara
et al.
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963-972
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Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence
09 January 2012
Stress-induced premature senescence (SIPS) of endothelial cells (ECs) has emerged as a contributor to global EC dysfunction. One of the cellular abnormalities mechanistically linked to SIPS is lysosom...
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Jun Chen,
Sandhya Xavier,
Eliza Moskowitz-Kassai,
Robert Chen,
Connie Y. Lu,
Kyle Sanduski,
Aleš Špes,
Boris Turk,
Michael S. Goligorsky
et al.
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973-983
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| Gastrointestinal, Hepatobiliary, and Pancreatic Pathology |
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Epithelial Expression of the Cytosolic Retinoid Chaperone Cellular Retinol Binding Protein II Is Essential for in Vivo Imprinting of Local Gut Dendritic Cells by Lumenal Retinoids
04 January 2012
Dendritic cells (DCs) use all-trans retinoic acid (ATRA) to promote characteristic intestinal responses, including Foxp3+ Treg conversion, lymphocyte gut homing molecule expression, and IgA production...
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Keely G. McDonald,
Matthew R. Leach,
Kaitlin W.M. Brooke,
Caihong Wang,
Leroy W. Wheeler,
Elyse K. Hanly,
Christopher W. Rowley,
Marc S. Levin,
Michael Wagner,
Ellen Li,
Rodney D. Newberry
et al.
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984-997
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Chronic Alcohol Exposure Stimulates Adipose Tissue Lipolysis in Mice: Role of Reverse Triglyceride Transport in the Pathogenesis of Alcoholic Steatosis
09 January 2012
Alcohol consumption induces liver steatosis; therefore, this study investigated the possible role of adipose tissue dysfunction in the pathogenesis of alcoholic steatosis. Mice were pair-fed an alcoho...
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Wei Zhong,
Yantao Zhao,
Yunan Tang,
Xiaoli Wei,
Xue Shi,
Wenlong Sun,
Xiuhua Sun,
Xinmin Yin,
Xinguo Sun,
Seongho Kim,
Craig J. McClain,
Xiang Zhang,
Zhanxiang Zhou
et al.
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998-1007
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| Growth Factors, Cytokines, and Cell Cycle Molecules |
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Regulation of Monocyte Chemoattractant Protein-1 Through Angiotensin II Type 1 Receptor in Prostate Cancer
09 January 2012
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is reported to contribute to tumor progression and is regulated by the renin-angiotensin system in hypertensive disease. In this study, we investigated ...
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Suguru Shirotake,
Akira Miyajima,
Takeo Kosaka,
Nobuyuki Tanaka,
Eiji Kikuchi,
Shuji Mikami,
Yasunori Okada,
Mototsugu Oya
et al.
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1008-1016
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PTEN Regulates PDGF Ligand Switch for β-PDGFR Signaling in Prostate Cancer
29 December 2011
Platelet-derived growth factor (PDGF) family members are potent growth factors that regulate cell proliferation, migration, and transformation. Clinical studies have shown that both PDGF receptor β (β...
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M. Katie Conley-LaComb,
Wei Huang,
Shihua Wang,
Dongping Shi,
Young Suk Jung,
Abdo Najy,
Rafael Fridman,
R. Daniel Bonfil,
Michael L. Cher,
Yong Q. Chen,
Hyeong-Reh Choi Kim
et al.
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1017-1027
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| Immunopathology and Infectious Diseases |
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Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction
18 January 2012
Plasmodium falciparum is a protozoan parasite of human erythrocytes that causes the most severe form of malaria. Severe P. falciparum infection is associated with endothelial activation and permeabili...
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Mark R. Gillrie,
Kristine Lee,
D. Channe Gowda,
Shevaun P. Davis,
Marc Monestier,
Liwang Cui,
Tran Tinh Hien,
Nicholas P.J. Day,
May Ho
et al.
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1028-1039
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Chemokine Receptor CCR1 Disruption Limits Renal Damage in a Murine Model of Hemolytic Uremic Syndrome
27 December 2011
Shiga toxin (Stx)–producing Escherichia coli is the main etiological agent that causes hemolytic uremic syndrome (HUS), a microangiopathic disease characterized by hemolytic anemia, thrombocytopenia, ...
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Maria V. Ramos,
Constance Auvynet,
Lucie Poupel,
Mathieu Rodero,
Maria Pilar Mejias,
Cecilia A. Panek,
Silvia Vanzulli,
Christophe Combadiere,
Marina Palermo
et al.
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1040-1048
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p47phox Directs Murine Macrophage Cell Fate Decisions
04 January 2012
Macrophage differentiation and function are pivotal for cell survival from infection and involve the processing of microenvironmental signals that determine macrophage cell fate decisions to establish...
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Liang Yi,
Qi Liu,
Marlene S. Orandle,
Sara Sadiq-Ali,
Sherry M. Koontz,
Uimook Choi,
Fernando J. Torres-Velez,
Sharon H. Jackson
et al.
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1049-1058
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Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Exacerbates Collagen-Induced Arthritis by Enhancing the Expansion of Th17 Cells
04 January 2012
Rheumatoid arthritis (RA), a chronic autoimmune form of inflammatory joint disease, progressively affects multiple joints with pathological changes in the synovia, cartilage, and bone. Numerous studie...
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Shengjun Wang,
Ye Shi,
Min Yang,
Jie Ma,
Jie Tian,
Jianguo Chen,
Chaoming Mao,
Zhijun Jiao,
King-Hung Ko,
Samuel Essien Baidoo,
Huaxi Xu,
Zichun Hua,
Liwei Lu
et al.
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1059-1067
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Morphine Decreases Bacterial Phagocytosis by Inhibiting Actin Polymerization through cAMP-, Rac-1-, and p38 MAPK-Dependent Mechanisms
16 January 2012
Morphine increases the susceptibility to opportunistic infection by attenuating bacterial clearance through inhibition of Fcγ receptor (FcgR)–mediated phagocytosis. Mechanisms by which morphine inhibi...
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Jana Ninković,
Sabita Roy
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1068-1079
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Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets
13 January 2012
Development of personalized treatment regimens is hampered by lack of insight into how individual animal models reflect subsets of human disease, and autoimmune and inflammatory conditions have proven...
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Matthew B. Greenblatt,
Jennifer L. Sargent,
Giuseppina Farina,
Kelly Tsang,
Robert Lafyatis,
Laurie H. Glimcher,
Michael L. Whitfield,
Antonios O. Aliprantis
et al.
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1080-1094
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JC Virus Intranuclear Inclusions Associated with PML-NBs: Analysis by Electron Microscopy and Structured Illumination Microscopy
24 January 2012
Progressive multifocal leukoencephalopathy is a fatal demyelinating disorder caused by JC virus infection. JC virus was recently found to target promyelocytic leukemia nuclear bodies (PML-NBs), punctu...
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Yukiko Shishido-Hara,
Shizuko Ichinose,
Toshiki Uchihara
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1095-1106
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| Neurobiology |
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Neural Stem Cell Depletion and CNS Developmental Defects After Enteroviral Infection
04 January 2012
Coxsackieviruses are significant human pathogens causing myocarditis, meningitis, and encephalitis. We previously demonstrated the ability of coxsackievirus B3 (CVB3) to persist within the neonatal ce...
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Chelsea M. Ruller,
Jenna M. Tabor-Godwin,
Donn A. Van Deren,
Scott M. Robinson,
Sonia Maciejewski,
Shea Gluhm,
Paul E. Gilbert,
Naili An,
Natalie A. Gude,
Mark A. Sussman,
J. Lindsay Whitton,
Ralph Feuer
et al.
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1107-1120
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Growth Defects and Impaired Cognitive–Behavioral Abilities in Mice with Knockout for Eif4h, a Gene Located in the Mouse Homolog of the Williams-Beuren Syndrome Critical Region
09 January 2012
Protein synthesis is a tightly regulated, energy-consuming process. The control of mRNA translation into protein is fundamentally important for the fine-tuning of gene expression; additionally, precis...
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Simona Capossela,
Luca Muzio,
Alessandro Bertolo,
Veronica Bianchi,
Gabriele Dati,
Linda Chaabane,
Claudia Godi,
Letterio S. Politi,
Stefano Biffo,
Patrizia D'Adamo,
Antonello Mallamaci,
Maria Pannese
et al.
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1121-1135
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Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities
09 January 2012
Platelet-derived growth factors (PDGFs) and their tyrosine kinase receptors (PDGFRs) are known to play important roles during development of the lungs, central nervous system (CNS), and skeleton and i...
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Linda Fredriksson,
Ingrid Nilsson,
Enming J. Su,
Johanna Andrae,
Hao Ding,
Christer Betsholtz,
Ulf Eriksson,
Daniel A. Lawrence
et al.
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1136-1144
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| Tumorigenesis and Neoplastic Progression |
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Collagen VI Ablation Retards Brain Tumor Progression Due to Deficits in Assembly of the Vascular Basal Lamina
26 December 2011
To investigate the importance of the vascular basal lamina in tumor blood vessel morphogenesis and function, we compared vessel development, vessel function, and progression of B16F10 melanoma tumors ...
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Weon-Kyoo You,
Paolo Bonaldo,
William B. Stallcup
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1145-1158
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ALDH1-Bright Epithelial Ovarian Cancer Cells Are Associated with CD44 Expression, Drug Resistance, and Poor Clinical Outcome
04 January 2012
The role of aldehyde dehydrogenase 1 (ALDH1) as an ovarian cancer stem cell marker and its clinical significance have rarely been explored. We used an Aldefluor assay to isolate ALDH1-bright (ALDH1br)...
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Yu-Chi Wang,
Yi-Te Yo,
Hsin-Yi Lee,
Yu-Ping Liao,
Tai-Kuang Chao,
Po-Hsuan Su,
Hung-Cheng Lai
et al.
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1159-1169
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Clinical and Biological Significance of KISS1 Expression in Prostate Cancer
09 January 2012
For men in the United States, prostate cancer (PCa) is the most frequent malignancy and the second leading cause of cancer mortality. The metastatic spread of PCa is responsible for most deaths relate...
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Honghe Wang,
Jacqueline Jones,
Timothy Turner,
Qinghua P. He,
Shana Hardy,
William E. Grizzle,
Danny R. Welch,
Clayton Yates
et al.
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1170-1178
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Mutant BRAF Induces DNA Strand Breaks, Activates DNA Damage Response Pathway, and Up-Regulates Glucose Transporter-1 in Nontransformed Epithelial Cells
06 January 2012
Although the oncogenic functions of activating BRAF mutations have been clearly demonstrated in human cancer, their roles in nontransformed epithelial cells remain largely unclear. Investigating the c...
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Jim Jinn-Chyuan Sheu,
Bin Guan,
Fuu-Jen Tsai,
Erin Yi-Ting Hsiao,
Chih-Mei Chen,
Raquel Seruca,
Tian-Li Wang,
Ie-Ming Shih
et al.
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1179-1188
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Role of ERRF, a Novel ER-Related Nuclear Factor, in the Growth Control of ER-Positive Human Breast Cancer Cells
Whereas estrogen–estrogen receptor α (ER) signaling plays an important role in breast cancer growth, it is also necessary for the differentiation of normal breast epithelial cells. How this functional...
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Dan Su,
Xiaoying Fu,
Songqing Fan,
Xiao Wu,
Xin-Xin Wang,
Liya Fu,
Xue-Yuan Dong,
Jianping Jenny Ni,
Li Fu,
Zhengmao Zhu,
Jin-Tang Dong
et al.
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1189-1201
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The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non–Small Cell Lung Cancer
16 January 2012
The aim of the present work was to identify protein tyrosine phosphatases (PTPs) as novel, candidate tumor suppressor genes in lung cancer. Among the 38 PTPs in the human genome that show specificity ...
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Marianna Scrima,
Carmela De Marco,
Fernanda De Vita,
Fernanda Fabiani,
Renato Franco,
Giuseppe Pirozzi,
Gaetano Rocco,
Donatella Malanga,
Giuseppe Viglietto
et al.
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1202-1214
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CXCR6 and CCR5 Localize T Lymphocyte Subsets in Nasopharyngeal Carcinoma
09 January 2012
The substantial T lymphocyte infiltrate found in cases of nasopharyngeal carcinoma (NPC) has been implicated in the promotion of both tumor growth and immune escape. Conversely, because malignant NPC ...
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Greg Parsonage,
Lee Richard Machado,
Jan Wai-Ying Hui,
Andrew McLarnon,
Tilo Schmaler,
Meenarani Balasothy,
Ka-Fai To,
Alexander C. Vlantis,
Charles A. van Hasselt,
Kwok-Wai Lo,
Wai-Lap Wong,
Edwin Pun Hui,
Anthony Tak Cheung Chan,
Steven P. Lee
et al.
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1215-1222
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High Anaplastic Lymphoma Kinase Immunohistochemical Staining in Neuroblastoma and Ganglioneuroblastoma Is an Independent Predictor of Poor Outcome
27 December 2011
Anaplastic lymphoma kinase (ALK) mutations occur in 3% to 11% of neuroblastoma (NBL) cases and are associated with high ALK levels. However, high ALK levels appear to be a mutation-independent hallmar...
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Floor A.M. Duijkers,
José Gaal,
Jules P.P. Meijerink,
Pieter Admiraal,
Rob Pieters,
Ronald R. de Krijger,
Max M. van Noesel
et al.
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1223-1231
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Plexin-B1 and Semaphorin 4D Cooperate to Promote Perineural Invasion in a RhoA/ROK-Dependent Manner
16 January 2012
Perineural invasion (PNI) is a tropism of tumor cells for nerve bundles located in the surrounding stroma. It is a pathological feature observed in certain tumors, referred to as neurotropic malignanc...
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Nada O. Binmadi,
Ying-Hua Yang,
Hua Zhou,
Patrizia Proia,
Yi-Ling Lin,
Alfredo M. Batista De Paula,
André L. Sena Guimarães,
Fabiano O. Poswar,
Devaki Sundararajan,
John R. Basile
et al.
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1232-1242
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| Vascular Biology, Atherosclerosis, and Endothelium Biology |
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VEGF-Mediated STAT3 Activation Inhibits Retinal Vascularization by Down-Regulating Local Erythropoietin Expression
09 January 2012
Avascular, hypoxic retina has been postulated to be a source of angiogenic factors that cause aberrant angiogenesis and intravitreal neovascularization (IVNV) in retinopathy of prematurity. Vascular e...
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Haibo Wang,
Grace Byfield,
Yanchao Jiang,
George Wesley Smith,
Manabu McCloskey,
M. Elizabeth Hartnett
et al.
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1243-1253
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Deficiency of Interleukin-1 Receptor Antagonist Promotes Spontaneous Femoral Artery Aneurysm Formation in Mice
13 January 2012
Femoral artery aneurysms (FAAs) are very rare, and their natural history is not well understood. In this study, we sought to analyze the pathogenesis of inflammatory FAAs in interleukin-1 receptor ant...
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Kikuo Isoda,
Manabu Kitagaki,
Tomiharu Niida,
Harumi Kondo,
Osamu Matsubara,
Makoto Kikuchi,
Fumitaka Ohsuzu,
Takeshi Adachi
et al.
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1254-1263
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Chlamydophila pneumoniae Infection Induces Alterations in Vascular Contractile Responses
04 January 2012
Chlamydophila pneumoniae infection has been associated in previous studies with coronary artery disease. The live bacterium has been detected within atherosclerotic plaques and can induce the structur...
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Justin F. Deniset,
Thomas E. Hedley,
Elena Dibrov,
Grant N. Pierce
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1264-1272
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Promotion of Lymphatic Integrity by Angiopoietin-1/Tie2 Signaling during Inflammation
26 December 2011
The cutaneous lymphatic system plays a major role in tissue fluid homeostasis and inflammation of the skin. Although several lymphangiogenic factors are known to be involved in the formation of lympha...
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Kentaro Kajiya,
Hiroyasu Kidoya,
Mika Sawane,
Yuuko Matsumoto-Okazaki,
Haruyo Yamanishi,
Mikio Furuse,
Nobuyuki Takakura
et al.
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1273-1282
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Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment
16 January 2012
Tumor endothelial cells (TECs) are therapeutic targets in anti-angiogenic therapy. Contrary to the traditional assumption, TECs can be genetically abnormal and might also acquire drug resistance. In t...
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Kosuke Akiyama,
Noritaka Ohga,
Yasuhiro Hida,
Taisuke Kawamoto,
Yoshihiro Sadamoto,
Shuhei Ishikawa,
Nako Maishi,
Tomoshige Akino,
Miyako Kondoh,
Aya Matsuda,
Nobuo Inoue,
Masanobu Shindoh,
Kyoko Hida
et al.
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1283-1293
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Heterogeneity of Tumor Endothelial Cells: Comparison between Tumor Endothelial Cells Isolated from High- and Low-Metastatic Tumors
16 January 2012
An important concept in tumor angiogenesis is that tumor endothelial cells (TECs) are genetically normal and homogeneous. However, we previously reported that TECs differ from normal ECs. Whether the ...
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Noritaka Ohga,
Shuhei Ishikawa,
Nako Maishi,
Kosuke Akiyama,
Yasuhiro Hida,
Taisuke Kawamoto,
Yoshihiro Sadamoto,
Takahiro Osawa,
Kazuyuki Yamamoto,
Miyako Kondoh,
Hitomi Ohmura,
Nobuo Shinohara,
Katsuya Nonomura,
Masanobu Shindoh,
Kyoko Hida
et al.
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1294-1307
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Co-Regulation of Transcellular and Paracellular Leak Across Microvascular Endothelium by Dynamin and Rac
27 December 2011
Increased permeability of the microvascular endothelium to fluids and proteins is the hallmark of inflammatory conditions such as sepsis. Leakage can occur between (paracellular) or through (transcyto...
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Susan M. Armstrong,
Vahid Khajoee,
Changsen Wang,
Tieling Wang,
Jayesh Tigdi,
Jun Yin,
Wolfgang M. Kuebler,
Mark Gillrie,
Shevaun P. Davis,
May Ho,
Warren L. Lee
et al.
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1308-1323
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| Corrections |
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Corrections
In the article entitled, “SPARC Oppositely Regulates Inflammation and Fibrosis in Bleomycin-Induced Lung Damage” (Volume 179, pages 3000–3010 of the December 2011 issue of The American Journal of Path...
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| Reviewer Acknowledgment |
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Reviewer Acknowledgment
The Editors gratefully acknowledge the generous assistance of the following reviewers who served The American Journal of Pathology between January 1 and December 31, 2011.
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1325-1331
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Instructions to Authors
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Editorial Board
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A1-A2
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Table of Contents
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A3-A6
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Scientific Integrity Policy
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A11-A12
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