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Editorial Board
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i
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Editorial Board
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ii
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IBMS Board of Directors
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xi
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IBMS Corporate Partners
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xii
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IBMS Membership Application
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xiii
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Article Title |
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Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos
Abstract: Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation. However, the molecular mechanism un...
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Long He,
Junwon Lee,
Jae Hyuk Jang,
Sung-Hoon Lee,
Mei Hua Nan,
Byung-Chul Oh,
Sang Gu Lee,
Hong Hee Kim,
Nak Kyun Soung,
Jong Seog Ahn,
Bo Yeon Kim
et al.
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1207-1213
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Chronic exposure to methylphenidate impairs appendicular bone quality in young rats
Abstract: Methylphenidate (MP) is a psychostimulant widely prescribed to treat Attention Deficit Hyperactivity Disorder (ADHD). Although generally well tolerated, growth deficits have been reported in...
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David E. Komatsu,
Panayotis K. Thanos,
Michelle N. Mary,
Haden A. Janda,
Christine M. John,
Lisa Robison,
Mala Ananth,
James M. Swanson,
Nora D. Volkow,
Michael Hadjiargyrou
et al.
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1214-1222
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Attenuated Wnt/β-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats
Abstract: Cancer chemotherapy often causes significant bone loss, marrow adiposity and haematopoietic defects, yet the underlying mechanisms and recovery potential remain unclear. Wnt/β-catenin signal...
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Kristen R. Georgiou,
Tristan J. King,
Michaela A. Scherer,
Hong Zhou,
Bruce K. Foster,
Cory J. Xian
et al.
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1223-1233
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Risk factors for osteoporosis in Caucasian patients with moderate chronic obstructive pulmonary disease: A case control study
Abstract: The prevalence of osteoporosis is high in chronic obstructive pulmonary disease (COPD) patients. The gold standard for the diagnosis of osteoporosis is bone mineral density (BMD) measurement...
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Lidwien Graat-Verboom,
Frank W.J.M. Smeenk,
Ben E.E.M. van den Borne,
Martijn A. Spruit,
Astrid B. Donkers-van Rossum,
Renske P.M. Aarts,
Emiel F.M. Wouters
et al.
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1234-1239
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Expression of osteoblastic and osteoclastic genes during spontaneous regeneration and autotransplantation of goldfish scale: A new tool to study intramembranous bone regeneration
Abstract: Complementary DNA of osteoblast-specific genes (dlx5, runx2a, runx2b, osterix, RANKL, type I collagen, ALP, and osteocalcin) was cloned from goldfish (Carassius auratus) scale. Messenger RNA...
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Thiparpa Aime Thamamongood,
Ryo Furuya,
Shunsuke Fukuba,
Masahisa Nakamura,
Nobuo Suzuki,
Atsuhiko Hattori
et al.
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1240-1249
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Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis
Abstract: Objective: To investigate the disease modifying effects of cathepsin K (CatK) inhibitor L-006235 compared to alendronate (ALN) in two preclinical models of osteoarthritis (OA). Methods: Skel...
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Tadashi Hayami,
Ya Zhuo,
Gregg A. Wesolowski,
Maureen Pickarski,
Le T. Duong
et al.
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1250-1259
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5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients
26 March 2012
Abstract: In patients with a carcinoid syndrome and neuroendocrine tumors of the digestive tract (carcinoids), elevated circulating serotonin (5-hydroxytryptamine, 5-HT) levels can be demonstrated. It...
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S.C. van Dijk,
W.W. de Herder,
D.J. Kwekkeboom,
M.C. Zillikens,
R.A. Feelders,
R.H.N. van Schaik,
M. van Driel,
J.P.T.M. van Leeuwen
et al.
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1260-1265
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Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis
26 March 2012
Abstract: Purpose: Low 25-hydroxyvitamin D (25D), increased levels of fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and alkaline phosphatase (ALP) were reported to be risk factors fo...
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Chikako Nakano,
Takayuki Hamano,
Naohiko Fujii,
Yoshitsugu Obi,
Isao Matsui,
Kodo Tomida,
Satoshi Mikami,
Kazunori Inoue,
Akihiro Shimomura,
Yasuyuki Nagasawa,
Noriyuki Okada,
Yoshiharu Tsubakihara,
Hiromi Rakugi,
Yoshitaka Isaka
et al.
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1266-1274
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Effects of mineral content on the fracture properties of equine cortical bone in double-notched beams
27 March 2012
Abstract: We recently developed a method to measure cortical bone fracture initiation toughness using a double-notched beam in four-point bending. This method was used to test the hypothesis that mine...
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Jordan McCormack,
Susan M. Stover,
Jeffery C. Gibeling,
David P. Fyhrie
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1275-1280
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Mechanical failure begins preferentially near resorption cavities in human vertebral cancellous bone under compression
30 March 2012
Abstract: The amount of bone turnover in the body has been implicated as a factor that can influence fracture risk and bone strength. Here we test the idea that remodeling cavities promote local tissu...
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C.R. Slyfield,
E.V. Tkachenko,
S.E. Fischer,
K.M. Ehlert,
I.H. Yi,
M.G. Jekir,
R.G. O'Brien,
T.M. Keaveny,
C.J. Hernandez
et al.
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1281-1287
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Effect of co-morbidities on fracture risk: Findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW)
30 March 2012
Abstract: Introduction: Greater awareness of the relationship between co-morbidities and fracture risk may improve fracture-prediction algorithms such as FRAX. Materials and methods: We used a large, ...
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Elaine M. Dennison,
Juliet E. Compston,
Julie Flahive,
Ethel S. Siris,
Stephen H. Gehlbach,
Jonathan D. Adachi,
Steven Boonen,
Roland Chapurlat,
Adolfo Díez-Pérez,
Frederick A. Anderson,
Frederick H. Hooven,
Andrea Z. LaCroix,
Robert Lindsay,
J. Coen Netelenbos,
Johannes Pfeilschifter,
Maurizio Rossini,
Christian Roux,
Kenneth G. Saag,
Philip Sambrook,
Stuart Silverman,
Nelson B. Watts,
Susan L. Greenspan,
Melissa Premaor,
Cyrus Cooper,
for the GLOW Investigators
et al.
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1288-1293
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A novel library screen identifies immunosuppressors that promote osteoblast differentiation
05 April 2012
Abstract: Bone homeostasis can be compromised by an increase in osteoclast-mediated resorption and/or a decrease in osteoblast-mediated bone deposition. While many efforts have focused on treating ost...
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Ariana Darcy,
Micah Meltzer,
Joseph Miller,
Steven Lee,
Scott Chappell,
Kris Ver Donck,
Monty Montano
et al.
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1294-1303
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Quality control for bone quality parameters affected by subject motion in high-resolution peripheral quantitative computed tomography
05 April 2012
Abstract: Subject motion during high-resolution peripheral quantitative computed tomography (HR-pQCT) causes image artifacts that affect morphological analysis of bone quality. The aim of our study wa...
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Yves Pauchard,
Anna-Maria Liphardt,
Heather M. Macdonald,
David A. Hanley,
Steven K. Boyd
et al.
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1304-1310
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Serum free estradiol and estrogen receptor-α mediated activity are related to decreased incident hip fractures in older women
04 April 2012
Abstract: There is paucity of data from Asian women on the association between serum estrogens and osteoporotic hip fracture risk. We conducted a case–control study nested within a population-based pr...
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Vanessa W. Lim,
Jun Li,
Yinhan Gong,
Jian-Min Yuan,
Tsung Sheng Wu,
Geoffrey L. Hammond,
Aizhen Jin,
Woon-Puay Koh,
E.L. Yong
et al.
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1311-1316
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Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice
05 April 2012
Abstract: Bone is a complex material with a hierarchical multi-scale organization from the molecule to the organ scale. The genetic bone disease, osteogenesis imperfecta, is primarily caused by mutati...
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Maximilien Vanleene,
Alexandra Porter,
Pascale-Valerie Guillot,
Alan Boyde,
Michelle Oyen,
Sandra Shefelbine
et al.
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1317-1323
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Age and sex differences in tibia morphology in healthy adult Caucasians
05 April 2012
Abstract: Variability in peripheral Quantitative Computed Tomography (pQCT) measurement sites limits direct comparisons of results between studies. Further, it is unclear what estimates of bone streng...
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Vanessa D. Sherk,
Debra A. Bemben,
Michael G. Bemben,
Mark A. Anderson
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1324-1331
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Pharmacodynamic Responses to combined treatment regimens with the calcium sensing receptor antagonist JTT-305/MK-5442 and alendronate in osteopenic ovariectomized rats
05 April 2012
Abstract: Parathyroid hormone (PTH) is the anabolic standard of care for patients with severe osteoporosis. The CaSR allosteric antagonist JTT-305/MK-5442, a PTH secretagogue, could offer an oral oste...
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John E. Fisher,
Kevin Scott,
Nan Wei,
Jing Z. Zhao,
Tara Cusick,
Monica Tijerina,
Bindhu Karanam,
Le Duong,
Helmut Glantschnig
et al.
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1332-1342
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Prediction of survival, second fracture, and functional recovery following the first hip fracture surgery in elderly patients
05 April 2012
Abstract: This study was designed to investigate predictable factors of mortality, second fracture, and functional recovery within 24months of hip fracture surgery in elderly patients. In addition, th...
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Sang-Min Kim,
Young-Wan Moon,
Seung-Jae Lim,
Byung-Koo Yoon,
Yong-Ki Min,
Dong-Yun Lee,
Youn-Soo Park
et al.
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1343-1350
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Iron status and fibroblast growth factor-23 in Gambian children
09 April 2012
Abstract: A relationship between iron and fibroblast growth factor-23 (FGF23) metabolic pathways has been proposed. Iron deficiency anaemia is prevalent in The Gambia and concentrations of fibroblast ...
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Vickie Braithwaite,
Landing M.A. Jarjou,
Gail R. Goldberg,
Ann Prentice
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1351-1356
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Micro-computed tomography assessment of the progression of fracture healing in mice
09 April 2012
Abstract: The mouse fracture model is ideal for research into the pathways of healing because of the availability of genetic and transgenic mice and the ability to create cell-specific genetic mutatio...
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Kevin R. O'Neill,
Christopher M. Stutz,
Nicholas A. Mignemi,
Michael C. Burns,
Matthew R. Murry,
Jeffry S. Nyman,
Jonathan G. Schoenecker
et al.
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1357-1367
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Changes in vitamin D metabolites during teriparatide treatment
11 April 2012
Abstract: Parathyroid hormone (PTH) increases the conversion of 25-hydroxyvitamin D [25(OH)D] to 1,25 dihydroxyvitamin D [1,25(OH)2D]. The purpose of this study was to assess the changes in serum conc...
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Felicia Cosman,
Bess Dawson-Hughes,
Xiaohai Wan,
John H. Krege
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1368-1371
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Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women
13 April 2012
Abstract: Osteoporosis and its main health outcome, fragility fractures, are large and escalating public health problems. Cadmium, a widespread food contaminant, is a proposed risk factor; still the a...
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Annette Engström,
Karl Michaëlsson,
Marie Vahter,
Bettina Julin,
Alicja Wolk,
Agneta Åkesson
et al.
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1372-1378
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Evaluation of high-resolution peripheral quantitative computed tomography, finite element analysis and biomechanical testing in a pre-clinical model of osteoporosis: A study with odanacatib treatment in the ovariectomized adult rhesus monkey
13 April 2012
Abstract: This study aimed to validate finite element analysis (FEA) estimation of strength, identify high-resolution peripheral quantitative computed tomography (HR-pQCT) measures correlating with st...
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Richa Y. Jayakar,
Antonio Cabal,
John Szumiloski,
Swanand Sardesai,
Eual A. Phillips,
Andres Laib,
Boyd B. Scott,
Maureen Pickarski,
Le T. Duong,
Christopher T. Winkelmann,
Paul J. McCracken,
Richard Hargreaves,
Thomas N. Hangartner,
Donald S. Williams
et al.
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1379-1388
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Five years of anti-resorptive activity after a single dose of zoledronate — Results from a randomized double-blind placebo-controlled trial
12 April 2012
Abstract: Intravenous zoledronate 5mg, administered annually, prevents fractures in people with osteoporosis, but the optimal dosing schedule is not known. Previously, we reported that a single dose o...
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Andrew Grey,
Mark J. Bolland,
Anne Horne,
Diana Wattie,
Meaghan House,
Greg Gamble,
Ian R. Reid
et al.
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1389-1393
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Different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women
13 April 2012
Abstract: While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures ...
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Miranda E.G. Armstrong,
Benjamin J. Cairns,
Emily Banks,
Jane Green,
Gillian K. Reeves,
Valerie Beral,
Million Women Study Collaborators
et al.
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1394-1400
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The association between plasma homocysteine levels, methylation capacity and incident osteoporotic fractures
12 April 2012
Abstract: Background: An elevated level of plasma homocysteine (Hcy) is a known risk factor for osteoporotic fractures. In addition, Hcy is related to DNA-methylation metabolism. To determine whether ...
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A.W. Enneman,
N. van der Velde,
R. de Jonge,
S.G. Heil,
L. Stolk,
A. Hofman,
F. Rivadeneira,
M.C. Zillikens,
A.G. Uitterlinden,
J.B.J. van Meurs
et al.
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1401-1405
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Arsenic trioxide affects bone remodeling by effects on osteoblast differentiation and function
13 April 2012
Abstract: Arsenic trioxide (ATO) is widely used in tumor treatment, but excessive arsenic exposure can have adverse health effects. This study was to examine the association between ATO treatment and ...
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Yu-Chen Hu,
Hsiao-Ling Cheng,
Bau-Shan Hsieh,
Li-Wen Huang,
Tzu-Ching Huang,
Kee-Lung Chang
et al.
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1406-1415
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Failure strength of human vertebrae: Prediction using bone mineral density measured by DXA and bone volume by micro-CT
12 April 2012
Abstract: Significant relationships exist between areal bone mineral density (BMD) derived from dual energy X-ray absorptiometry (DXA) and bone strength. However, the predictive validity of BMD for os...
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Egon Perilli,
Andrew M. Briggs,
Susan Kantor,
John Codrington,
John D. Wark,
Ian H. Parkinson,
Nicola L. Fazzalari
et al.
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1416-1425
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