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Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy
24 May 2012
Philip J. Benson, Sara A. Beedie, Elizabeth Shephard, Ina Giegling, Dan Rujescu, David St. Clair
Background: We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control subjects and their predictive validity. Methods: A training set of 8...
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Systematic Meta-Analysis of Insula Volume in Schizophrenia
24 May 2012
Alana M. Shepherd, Sandra L. Matheson, Kristin R. Laurens, Vaughan J. Carr, Melissa J. Green
Background: Volume reduction in insular cortex may constitute an important neuropathology in schizophrenia. We provide the first meta-analysis of studies that conducted region-of-interest analyses of ...
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Male Germline Transmits Fetal Alcohol Adverse Effect on Hypothalamic Proopiomelanocortin Gene Across Generations
24 May 2012
Dmitry Govorko, Rola A. Bekdash, Changqing Zhang, Dipak K. Sarkar
Background: Neurons containing proopiomelanocortin (POMC)-derived peptides, known to control stress axis, metabolic, and immune functions, have a lower function in patients with a family history of al...
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Dynamics of Defensive Reactivity in Patients with Panic Disorder and Agoraphobia: Implications for the Etiology of Panic Disorder
24 May 2012
Jan Richter, Alfons O. Hamm, Christiane A. Pané-Farré, Alexander L. Gerlach, Andrew T. Gloster, Hans-Ulrich Wittchen, Thomas Lang, Georg W. Alpers, Sylvia Helbig-Lang, Jürgen Deckert, Thomas Fydrich, Lydia Fehm, Andreas Ströhle, Tilo Kircher, Volker Arolt
Background: The learning perspective of panic disorder distinguishes between acute panic and anxious apprehension as distinct emotional states. Following animal models, these clinical entities reflect...
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Distinct Age-Dependent Effects of Methylphenidate on Developing and Adult Prefrontal Neurons
21 May 2012
Kimberly R. Urban, Barry D. Waterhouse, Wen-Jun Gao
Background: Methylphenidate (MPH) has long been used to treat attention-deficit/hyperactivity disorder (ADHD); however, its cellular mechanisms of action and potential effects on prefrontal cortical c...
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