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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Simple Viewing Tests Can Detect Eye Movement Abnormalities That Distinguish Schizophrenia Cases from Controls with Exceptional Accuracy
DOI: 10.1016/j.biopsych.2012.04.019
Background: We have investigated which eye-movement tests alone and combined can best discriminate schizophrenia cases from control subjects and their predictive validity. Methods: A training set of 8...
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Philip J. Benson,
Sara A. Beedie,
Elizabeth Shephard,
Ina Giegling,
Dan Rujescu,
David St. Clair
et al.
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Full-length article
(In Press Corrected Proof)
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24 May 2012 |
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Systematic Meta-Analysis of Insula Volume in Schizophrenia
DOI: 10.1016/j.biopsych.2012.04.020
Background: Volume reduction in insular cortex may constitute an important neuropathology in schizophrenia. We provide the first meta-analysis of studies that conducted region-of-interest analyses of ...
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Alana M. Shepherd,
Sandra L. Matheson,
Kristin R. Laurens,
Vaughan J. Carr,
Melissa J. Green
et al.
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Full-length article
(In Press Corrected Proof)
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24 May 2012 |
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Male Germline Transmits Fetal Alcohol Adverse Effect on Hypothalamic Proopiomelanocortin Gene Across Generations
DOI: 10.1016/j.biopsych.2012.04.006
Background: Neurons containing proopiomelanocortin (POMC)-derived peptides, known to control stress axis, metabolic, and immune functions, have a lower function in patients with a family history of al...
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Dmitry Govorko,
Rola A. Bekdash,
Changqing Zhang,
Dipak K. Sarkar
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Full-length article
(In Press Corrected Proof)
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24 May 2012 |
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Dynamics of Defensive Reactivity in Patients with Panic Disorder and Agoraphobia: Implications for the Etiology of Panic Disorder
DOI: 10.1016/j.biopsych.2012.03.035
Background: The learning perspective of panic disorder distinguishes between acute panic and anxious apprehension as distinct emotional states. Following animal models, these clinical entities reflect...
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Jan Richter,
Alfons O. Hamm,
Christiane A. Pané-Farré,
Alexander L. Gerlach,
Andrew T. Gloster,
Hans-Ulrich Wittchen,
Thomas Lang,
Georg W. Alpers,
Sylvia Helbig-Lang,
Jürgen Deckert,
Thomas Fydrich,
Lydia Fehm,
Andreas Ströhle,
Tilo Kircher,
Volker Arolt
et al.
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Full-length article
(In Press Corrected Proof)
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24 May 2012 |
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Distinct Age-Dependent Effects of Methylphenidate on Developing and Adult Prefrontal Neurons
DOI: 10.1016/j.biopsych.2012.04.018
Background: Methylphenidate (MPH) has long been used to treat attention-deficit/hyperactivity disorder (ADHD); however, its cellular mechanisms of action and potential effects on prefrontal cortical c...
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Kimberly R. Urban,
Barry D. Waterhouse,
Wen-Jun Gao
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Neurotrophic Tyrosine Kinase Polymorphism Impacts White Matter Connections in Patients with Major Depressive Disorder
DOI: 10.1016/j.biopsych.2012.04.015
Background: Polymorphisms in the brain-derived neurotrophic factor (BDNF) gene and its receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) have been implicated in mood disorders. The aim of ...
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Melissa L. Murphy,
Angela Carballedo,
Andrew Fagan,
Derek Morris,
Ciara Fahey,
James Meaney,
Thomas Frodl
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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High Versus Low Level of Response to Alcohol: Evidence of Differential Reactivity to Emotional Stimuli
DOI: 10.1016/j.biopsych.2012.04.016
Background: The low level of response (LR) or sensitivity to alcohol is genetically influenced and predicts heavy drinking and alcohol problems. Functional magnetic resonance imaging (fMRI) studies us...
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Martin P. Paulus,
Marc A. Schuckit,
Susan F. Tapert,
Neil J. Tolentino,
Scott C. Matthews,
Tom L. Smith,
Ryan S. Trim,
Shana A. Hall,
Alan N. Simmons
et al.
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Full-length article
(In Press Corrected Proof)
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18 May 2012 |
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Reduced Dorsal Anterior Cingulate Cortical Activity During Emotional Regulation and Top-Down Attentional Control in Generalized Social Phobia, Generalized Anxiety Disorder, and Comorbid Generalized Social Phobia/Generalized Anxiety Disorder
DOI: 10.1016/j.biopsych.2012.04.013
Background: Generalized social phobia (GSP) and generalized anxiety disorder (GAD) are both associated with emotion dysregulation. Research implicates dorsal anterior cingulate cortex in both explicit...
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Karina S. Blair,
Marilla Geraci,
Bruce W. Smith,
Nick Hollon,
Jeffrey DeVido,
Marcela Otero,
James R. Blair,
Daniel S. Pine
et al.
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Full-length article
(In Press Corrected Proof)
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17 May 2012 |
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Alzheimer's Disease Genes and Cognition in the Nondemented General Population
DOI: 10.1016/j.biopsych.2012.04.009
Background: Genome-wide association studies have established 11 genes for late-onset Alzheimer's disease (AD). We investigated whether these genes jointly affect cognition in a nondemented population ...
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Benjamin F.J. Verhaaren,
Meike W. Vernooij,
Peter J. Koudstaal,
André G. Uitterlinden,
Cornelia M.van Duijn,
Albert Hofman,
Monique M.B. Breteler,
M. Arfan Ikram
et al.
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Full-length article
(In Press Corrected Proof)
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17 May 2012 |
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Deletion of CREB-Regulated Transcription Coactivator 1 Induces Pathological Aggression, Depression-Related Behaviors, and Neuroplasticity Genes Dysregulation in Mice
DOI: 10.1016/j.biopsych.2012.04.011
Background: Mood disorders are polygenic disorders in which the alteration of several susceptibility genes results in dysfunctional mood regulation. However, the molecular mechanisms underlying their ...
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Lionel Breuillaud,
Clara Rossetti,
Elsa M. Meylan,
Christophe Mérinat,
Olivier Halfon,
Pierre J. Magistretti,
Jean-René Cardinaux
et al.
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Full-length article
(In Press Corrected Proof)
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17 May 2012 |
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Psilocybin Biases Facial Recognition, Goal-Directed Behavior, and Mood State Toward Positive Relative to Negative Emotions Through Different Serotonergic Subreceptors
DOI: 10.1016/j.biopsych.2012.04.005
Background: Serotonin (5-HT) 1A and 2A receptors have been associated with dysfunctional emotional processing biases in mood disorders. These receptors further predominantly mediate the subjective and...
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Michael Kometer,
André Schmidt,
Rosilla Bachmann,
Erich Studerus,
Erich Seifritz,
Franz X. Vollenweider
et al.
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Full-length article
(In Press Corrected Proof)
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14 May 2012 |
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Using Attentional Bias Modification as a Cognitive Vaccine Against Depression
DOI: 10.1016/j.biopsych.2012.04.014
Background: Negative attentional biases are thought to increase the risk of recurrence in depression, suggesting that reduction of such biases may be a plausible strategy in the secondary prevention o...
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Michael Browning,
Emily A. Holmes,
Matthew Charles,
Philip J. Cowen,
Catherine J. Harmer
et al.
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Full-length article
(In Press Corrected Proof)
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14 May 2012 |
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Understanding Interpersonal Function in Psychiatric Illness Through Multiplayer Economic Games
DOI: 10.1016/j.biopsych.2012.03.033
Interpersonal factors play significant roles in the onset, maintenance, and remission of psychiatric conditions. In the current major diagnostic classification systems for psychiatric disorders, some ...
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Brooks King-Casas,
Pearl H. Chiu
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Review article
(In Press Corrected Proof)
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14 May 2012 |
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Glucocorticoids Protect Against the Delayed Behavioral and Cellular Effects of Acute Stress on the Amygdala
DOI: 10.1016/j.biopsych.2012.04.008
Background: A single episode of acute immobilization stress has previously been shown to trigger a delayed onset of anxiety-like behavior and spinogenesis in the basolateral amygdala (BLA) of rats. Sp...
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Rajnish P. Rao,
Shobha Anilkumar,
Bruce S. McEwen,
Sumantra Chattarji
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Full-length article
(In Press Corrected Proof)
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10 May 2012 |
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Neural Activations During Auditory Oddball Processing Discriminating Schizophrenia and Psychotic Bipolar Disorder
DOI: 10.1016/j.biopsych.2012.03.034
Background: Reduced amplitude of the P300 event-related potential in auditory oddball tasks may characterize schizophrenia (SZ) but is also reported in bipolar disorder. Similarity of auditory process...
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Lauren E. Ethridge,
Jordan P. Hamm,
John R. Shapiro,
Ann T. Summerfelt,
Sarah K. Keedy,
Michael C. Stevens,
Godfrey Pearlson,
Carol A. Tamminga,
Nash N. Boutros,
John A. Sweeney,
Matcheri S. Keshavan,
Gunvant Thaker,
Brett A. Clementz
et al.
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Full-length article
(In Press Corrected Proof)
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10 May 2012 |
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Reply to: Lithium and the Expanding Brain
DOI: 10.1016/j.biopsych.2012.04.007
We thank Dr Regenold for his interest and comment on our recent article, in which we demonstrated that chronic lithium (Li) treatment increased both whole-brain volume and total cortical gray matter (...
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Anthony C. Vernon,
Sridhar Natesan,
William R. Crum,
Michel Modo,
Jonathan D. Cooper,
Steven C.R. Williams,
Shitij Kapur
et al.
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Correspondence
(In Press Corrected Proof)
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07 May 2012 |
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Potentiated Amygdala Response to Repeated Emotional Pictures in Borderline Personality Disorder
DOI: 10.1016/j.biopsych.2012.03.027
Background: Borderline personality disorder (BPD) is characterized by an inability to regulate emotional responses. The amygdala is important in learning about the valence (goodness and badness) of st...
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Erin A. Hazlett,
Jing Zhang,
Antonia S. New,
Yuliya Zelmanova,
Kim E. Goldstein,
M. Mehmet Haznedar,
David Meyerson,
Marianne Goodman,
Larry J. Siever,
King-Wai Chu
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Neuroeconomics of Attention-Deficit/Hyperactivity Disorder: Differential Influences of Medial, Dorsal, and Ventral Prefrontal Brain Networks on Suboptimal Decision Making?
DOI: 10.1016/j.biopsych.2012.04.004
Psychiatric neuroeconomics offers an alternative approach to understanding mental disorders by studying the way disorder-related neurobiological alterations constrain economic agency, as revealed thro...
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Edmund J.S. Sonuga-Barke,
Graeme Fairchild
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Review article
(In Press Corrected Proof)
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07 May 2012 |
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Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder
DOI: 10.1016/j.biopsych.2012.02.040
Background: Common genetic polymorphisms at chromosome 3p21.1, including rs2251219 in polybromo 1 (PBRM1), have been implicated in susceptibility to bipolar affective disorder (BP) through genome-wide...
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Evangelos Vassos,
Stacy Steinberg,
Sven Cichon,
Gerome Breen,
Engilbert Sigurdsson,
Ole A. Andreassen,
Srdjan Djurovic,
Gunnar Morken,
Maria Grigoroiu-Serbanescu,
Carmen C. Diaconu,
Piotr M. Czerski,
Joanna Hauser,
Gulja Babadjanova,
Lilia I. Abramova,
Thomas W. Mühleisen,
Markus M. Nöthen,
Marcella Rietschel,
Peter McGuffin,
David St. Clair,
Omar Gustafsson,
Ingrid Melle,
Olli P.H. Pietiläinen,
Mirella Ruggeri,
Sarah Tosato,
Thomas Werge,
Roel A. Ophoff,
GROUP Consortium,
Dan Rujescu,
Anders D. Børglum,
Ole Mors,
Preben B. Mortensen,
Ditte Demontis,
Mads V. Hollegaard,
Ruud van Winkel,
Gunter Kenis,
Marc De Hert,
János M. Réthelyi,
István Bitter,
I. Alex Rubino,
Vera Golimbet,
Lambertus A. Kiemeney,
Leonard H. van den Berg,
Barbara Franke,
Erik G. Jönsson,
Anne Farmer,
Hreinn Stefansson,
Kari Stefansson,
David A. Collier
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Lithium and the Expanding Brain
DOI: 10.1016/j.biopsych.2012.03.036
I read with great interest the article by Vernon et al. () entitled, “Contrasting Effects of Haloperidol and Lithium on Rodent Brain Structure: A Magnetic Resonance Imaging Study with Postmortem Confi...
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William T. Regenold
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Correspondence
(In Press Corrected Proof)
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04 May 2012 |
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Predictive Pursuit Association with Deficits in Working Memory in Psychosis
DOI: 10.1016/j.biopsych.2012.03.030
Background: Deficits in smooth pursuit eye movements are an established phenotype for schizophrenia (SZ) and are being investigated as a potential liability marker for bipolar disorder. Although the m...
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Amanda F. Moates,
Elena I. Ivleva,
Hugh B. O'Neill,
Nithin Krishna,
C. Munro Cullum,
Gunvant K. Thaker,
Carol A. Tamminga
et al.
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Full-length article
(In Press Corrected Proof)
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04 May 2012 |
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Tumor Necrosis Factor Gene Variation Predicts Hippocampus Volume in Healthy Individuals
DOI: 10.1016/j.biopsych.2012.04.002
Background: Cytokines such as tumor necrosis factor (TNF) α have been implicated in neurodegeneration relevant to various neuropsychiatric disorders. Little is known about the genetic predisposition t...
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Bernhard T. Baune,
Carsten Konrad,
Dominik Grotegerd,
Thomas Suslow,
Patricia Ohrmann,
Jochen Bauer,
Volker Arolt,
Walter Heindel,
Katharina Domschke,
Sonja Schöning,
Astrid Veronika Rauch,
Christina Sehlmeyer,
Harald Kugel,
Udo Dannlowski
et al.
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Full-length article
(In Press Corrected Proof)
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04 May 2012 |
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Methylphenidate Effects on Prefrontal Functioning During Attentional-Capture and Response Inhibition
DOI: 10.1016/j.biopsych.2012.03.028
Background: Methylphenidate improves motor response inhibition, typically assessed with the stop-signal task. The exact underlying mechanism for this, however, remains unknown. In addition, recent stu...
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Astrid M. Pauls,
Owen G. O'Daly,
Katya Rubia,
Wim J. Riedel,
Steven C.R. Williams,
Mitul A. Mehta
et al.
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Full-length article
(In Press Corrected Proof)
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03 May 2012 |
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Variant Brain Derived Neurotrophic Factor (Valine66Methionine) Polymorphism Contributes to Developmental and Estrous Stage–Specific Expression of Anxiety-Like Behavior in Female Mice
DOI: 10.1016/j.biopsych.2012.03.032
Background: Most anxiety and depressive disorders are twice as common in women compared with men, and the sex difference in prevalence typically emerges during adolescence. Hormonal changes across the...
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Kevin G. Bath,
Jocelyn Chuang,
Joanna L. Spencer-Segal,
Dima Amso,
Margaret Altemus,
Bruce S. McEwen,
Francis S. Lee
et al.
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Full-length article
(In Press Corrected Proof)
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03 May 2012 |
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Cigarette Smoking Predicts Differential Benefit from Naltrexone for Alcohol Dependence
DOI: 10.1016/j.biopsych.2012.03.023
Background: Identifying factors that modify responsiveness to pharmacotherapies for alcohol dependence is important for treatment planning. Cigarette smoking predicts more severe alcohol dependence an...
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Lisa M. Fucito,
Aesoon Park,
Suzy Bird Gulliver,
Margaret E. Mattson,
Ralitza V. Gueorguieva,
Stephanie S. O'Malley
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
DOI: 10.1016/j.biopsych.2012.03.013
Background: Fibroblast growth factor (FGF) signaling controls self-renewal of neural stem cells during embryonic telencephalic development. FGF receptor 2 (FGFR2) has a significant role in the product...
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Hanna E. Stevens,
Ginger Y. Jiang,
Michael L. Schwartz,
Flora M. Vaccarino
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Vocal Acoustic Biomarkers of Depression Severity and Treatment Response
DOI: 10.1016/j.biopsych.2012.03.015
Background: Valid, reliable biomarkers of depression severity and treatment response would provide new targets for clinical research. Noticeable differences in speech production between depressed and ...
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James C. Mundt,
Adam P. Vogel,
Douglas E. Feltner,
William R. Lenderking
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Protracted Withdrawal from Cocaine Self-Administration Flips the Switch on 5-HT1B Receptor Modulation of Cocaine Abuse-Related Behaviors
DOI: 10.1016/j.biopsych.2012.03.024
Background: The role of serotonin-1B receptors (5-HT1BRs) in modulating cocaine abuse-related behaviors has been controversial due to discrepancies between pharmacological and gene knockout approaches...
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Nathan S. Pentkowski,
Tim H.C. Cheung,
William A. Toy,
Matthew D. Adams,
John F. Neumaier,
Janet L. Neisewander
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse
DOI: 10.1016/j.biopsych.2012.03.022
Background: (±)-Modafinil has piqued interest as a treatment for attention-deficit/hyperactivity disorder and stimulant dependence. The R-enantiomer of modafinil might have unique pharmacological prop...
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Claus J. Loland,
Maddalena Mereu,
Oluyomi M. Okunola,
Jianjing Cao,
Thomas E. Prisinzano,
Sonia Mazier,
Theresa Kopajtic,
Lei Shi,
Jonathan L. Katz,
Gianluigi Tanda,
Amy Hauck Newman
et al.
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Full-length article
(In Press Corrected Proof)
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27 April 2012 |
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Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease
DOI: 10.1016/j.biopsych.2012.03.026
Background: Alzheimer's disease disrupts the topological architecture of whole-brain connectivity (i.e., the connectome); however, whether this disruption is present in amnestic mild cognitive impairm...
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Jinhui Wang,
Xinian Zuo,
Zhengjia Dai,
Mingrui Xia,
Zhilian Zhao,
Xiaoling Zhao,
Jianping Jia,
Ying Han,
Yong He
et al.
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Full-length article
(In Press Corrected Proof)
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27 April 2012 |
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SCN1A Affects Brain Structure and the Neural Activity of the Aging Brain
DOI: 10.1016/j.biopsych.2012.03.017
Background: The aging of the human brain is accompanied by changes in cortical structure as well as functional activity and variable degrees of cognitive decline. One-third of the observable inter-ind...
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Sandra Meier,
Traute Demirakca,
Wencke Brusniak,
Isabella Wolf,
Kristin Liebsch,
Nuran Tunc-Skarka,
Vanessa Nieratschker,
Stephanie H. Witt,
Franziska Matthäus,
Gabriele Ende,
Herta Flor,
Marcella Rietschel,
Carsten Diener,
Thomas G. Schulze
et al.
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Full-length article
(In Press Corrected Proof)
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26 April 2012 |
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Ventral Striatum Reactivity to Reward and Recent Life Stress Interact to Predict Positive Affect
DOI: 10.1016/j.biopsych.2012.03.014
Background: Stressful life events are among the most reliable precipitants of major depressive disorder; yet, not everyone exposed to stress develops depression. It has been hypothesized that robust n...
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Yuliya S. Nikolova,
Ryan Bogdan,
Bartholomew D. Brigidi,
Ahmad R. Hariri
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Full-length article
(In Press Corrected Proof)
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26 April 2012 |
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Neuroeconomics and the Study of Addiction
DOI: 10.1016/j.biopsych.2012.03.012
We review the key findings in the application of neuroeconomics to the study of addiction. Although there are not “bright line” boundaries between neuroeconomics and other areas of behavioral science,...
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John Monterosso,
Payam Piray,
Shan Luo
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Review article
(In Press Corrected Proof)
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23 April 2012 |
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Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans
DOI: 10.1016/j.biopsych.2012.02.038
Background: A genetic contribution to cannabis dependence (CaD) has been established but susceptibility genes for CaD remain largely unknown. Methods: We employed a multistage design to identify genet...
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Shizhong Han,
Bao-Zhu Yang,
Henry R. Kranzler,
David Oslin,
Raymond Anton,
Lindsay A. Farrer,
Joel Gelernter
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Maternal Care Influences Hippocampal N-Methyl-D-Aspartate Receptor Function and Dynamic Regulation by Corticosterone in Adulthood
DOI: 10.1016/j.biopsych.2012.03.016
Background: Variations in maternal care in the rat associate with robust differences in hippocampal development and synaptic plasticity in the offspring. Maternal care also influences pituitary-adrena...
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Rosemary C. Bagot,
Yiu Chung Tse,
Huy-Binh Nguyen,
Alice S. Wong,
Michael J. Meaney,
Tak Pan Wong
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Early-Life Mental Disorders and Adult Household Income in the World Mental Health Surveys
DOI: 10.1016/j.biopsych.2012.03.009
Background: Better information on the human capital costs of early-onset mental disorders could increase sensitivity of policy makers to the value of expanding initiatives for early detection and trea...
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Norito Kawakami,
Emad Abdulrazaq Abdulghani,
Jordi Alonso,
Evelyn J. Bromet,
Ronny Bruffaerts,
José Miguel Caldas-de-Almeida,
Wai Tat Chiu,
Giovanni de Girolamo,
Ron de Graaf,
John Fayyad,
Finola Ferry,
Silvia Florescu,
Oye Gureje,
Chiyi Hu,
Matthew D. Lakoma,
William LeBlanc,
Sing Lee,
Daphna Levinson,
Savita Malhotra,
Herbert Matschinger,
Maria Elena Medina-Mora,
Yosikazu Nakamura,
Mark A. Oakley Browne,
Michail Okoliyski,
Jose Posada-Villa,
Nancy A. Sampson,
Maria Carmen Viana,
Ronald C. Kessler
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Posttraumatic Stress Disorder Across Two Generations: Concordance and Mechanisms in a Population-Based Sample
DOI: 10.1016/j.biopsych.2012.03.020
Background: Research conducted using small samples of persons exposed to extreme stressors has documented an association between parental and offspring posttraumatic stress disorder (PTSD), but it is ...
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Andrea L. Roberts,
Sandro Galea,
S. Bryn Austin,
Magdalena Cerda,
Rosalind J. Wright,
Janet W. Rich-Edwards,
Karestan C. Koenen
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress
DOI: 10.1016/j.biopsych.2012.03.010
Background: Ghrelin plays important roles in glucose metabolism, appetite, and body weight regulation, and recent evidence suggests ghrelin prevents excessive anxiety under conditions of chronic stres...
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Sarah J. Spencer,
Lu Xu,
Melanie A. Clarke,
Moyra Lemus,
Alex Reichenbach,
Bram Geenen,
Tamás Kozicz,
Zane B. Andrews
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Reducing Behavioral Inhibition to Novelty via Systematic Neonatal Novelty Exposure: The Influence of Maternal Hypothalamic-Pituitary-Adrenal Regulation
DOI: 10.1016/j.biopsych.2012.03.021
Background: Behavioral inhibition (BI) to novelty is thought to be a stable temperament type that appears early in life and is a major risk factor for anxiety disorders. In the rat, habituation of suc...
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Akaysha C. Tang,
Bethany C. Reeb-Sutherland,
Russell D. Romeo,
Bruce S. McEwen
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Estimating the Genetic Variance of Major Depressive Disorder Due to All Single Nucleotide Polymorphisms
DOI: 10.1016/j.biopsych.2012.03.011
Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-...
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Gitta H. Lubke,
Jouke Jan Hottenga,
Raymond Walters,
Charles Laurin,
Eco J.C. de Geus,
Gonneke Willemsen,
Jan H. Smit,
Christel M. Middeldorp,
Brenda W.J.H. Penninx,
Jacqueline M. Vink,
Dorret I. Boomsma
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Synaptic Potentiation Is Critical for Rapid Antidepressant Response to Ketamine in Treatment-Resistant Major Depression
DOI: 10.1016/j.biopsych.2012.03.029
Background: Clinical evidence that ketamine, a nonselective N-methyl-D-aspartate receptor (NMDAR) antagonist, has therapeutic effects within hours in people suffering from depression suggests that mod...
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Brian R. Cornwell,
Giacomo Salvadore,
Maura Furey,
Craig A. Marquardt,
Nancy E. Brutsche,
Christian Grillon,
Carlos A. Zarate
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Relationship of Ketamine's Plasma Metabolites with Response, Diagnosis, and Side Effects in Major Depression
DOI: 10.1016/j.biopsych.2012.03.004
Background: Ketamine has rapid antidepressant effects lasting as long as 1 week in patients with major depressive disorder (MDD) and bipolar depression (BD). Ketamine is extensively metabolized. This ...
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Carlos A. Zarate,
Nancy Brutsche,
Gonzalo Laje,
David A. Luckenbaugh,
Swarajya L. Vattem Venkata,
Anuradha Ramamoorthy,
Ruin Moaddel,
Irving W. Wainer
et al.
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Full-length article
(In Press Corrected Proof)
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20 April 2012 |
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Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression
DOI: 10.1016/j.biopsych.2012.03.003
Background: Basic and clinical studies report that the expression of fibroblast growth factor-2 (FGF-2) is decreased in the prefrontal cortex (PFC) of depressed subjects or rodents exposed to stress a...
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Maha Elsayed,
Mounira Banasr,
Vanja Duric,
Neil M. Fournier,
Pawel Licznerski,
Ronald S. Duman
et al.
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Full-length article
(In Press Corrected Proof)
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19 April 2012 |
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Imaging Models of Valuation During Social Interaction in Humans
DOI: 10.1016/j.biopsych.2012.02.037
The role of dopamine neurons in value-guided behavior has been described in computationally explicit terms. These developments have motivated new model-based probes of reward processing in healthy hum...
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Kenneth T. Kishida,
P. Read Montague
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Review article
(In Press Corrected Proof)
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16 April 2012 |
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Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes
DOI: 10.1016/j.biopsych.2011.12.031
Background: Despite high heritability, the genetic variants influencing bipolar disorder (BD) susceptibility remain largely unknown. Low statistical power to detect the small effect-size alleles belie...
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Inti Pedroso,
Anbarasu Lourdusamy,
Marcella Rietschel,
Markus M. Nöthen,
Sven Cichon,
Peter McGuffin,
Ammar Al-Chalabi,
Michael R. Barnes,
Gerome Breen
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Optogenetics and Psychiatry: Applications, Challenges, and Opportunities
DOI: 10.1016/j.biopsych.2011.12.021
Achieving circuit-level insight into the fundamental nature of psychiatric symptoms has long proven elusive. Technological limitations have traditionally prevented cell type-targeted and temporally pr...
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Karl Deisseroth
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Discussion
(In Press Corrected Proof)
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16 April 2012 |
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Social Dominance in Female Monkeys: Dopamine Receptor Function and Cocaine Reinforcement
DOI: 10.1016/j.biopsych.2012.03.002
Background: Brain imaging and behavioral studies suggest an inverse relationship between dopamine (DA) D2/D3 receptors and vulnerability to cocaine abuse, although most research has used males. For ex...
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Michael A. Nader,
Susan H. Nader,
Paul W. Czoty,
Natallia V. Riddick,
H. Donald Gage,
Robert W. Gould,
Brandi L. Blaylock,
Jay R. Kaplan,
Pradeep K. Garg,
Huw M.L. Davies,
Daniel Morton,
Sudha Garg,
Beth A. Reboussin
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Deficient Inhibitory Cortical Networks in Antipsychotic-Naive Subjects at Risk of Developing First-Episode Psychosis and First-Episode Schizophrenia Patients: A Cross-Sectional Study
DOI: 10.1016/j.biopsych.2012.03.005
Background: Impaired cortical inhibition is a well-established finding in schizophrenia patients and has been linked to dysfunctional gamma-aminobutyric acid (GABA)ergic transmission. However, there h...
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Alkomiet Hasan,
Thomas Wobrock,
Christian Grefkes,
Marcin Labusga,
Katrin Levold,
Thomas Schneider-Axmann,
Peter Falkai,
Hendrik Müller,
Joachim Klosterkötter,
Andreas Bechdolf
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Estrogen Levels Are Associated with Extinction Deficits in Women with Posttraumatic Stress Disorder
DOI: 10.1016/j.biopsych.2012.02.031
Background: Women are twice as likely to develop posttraumatic stress disorder (PTSD) than men. As shown in our previous work, the inability to suppress fear responses in safe conditions may be a biom...
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Ebony M. Glover,
Tanja Jovanovic,
Kristina B. Mercer,
Kimberly Kerley,
Bekh Bradley,
Kerry J. Ressler,
Seth D. Norrholm
et al.
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Full-length article
(In Press Corrected Proof)
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16 April 2012 |
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Reply To: Brain-Derived Neurotrophic Factor in Patients With Chronic Hepatitis C: Beyond Neurotrophic Support
DOI: 10.1016/j.biopsych.2012.02.035
We read with great interest the correspondence by Fabregas et al. () in response to our letter, “Brain-derived neurotrophic factor predicts physical health in untreated patients with hepatitis C,” whi...
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Amirhossein Modabbernia,
Mandana Ashrafi,
Shervin Taslimi,
Hossein Poustchi
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Correspondence
(In Press Corrected Proof)
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13 April 2012 |
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On the Safety and Benefits of Repeated Intravenous Injections of Ketamine For Depression
DOI: 10.1016/j.biopsych.2012.02.039
The rapid and robust antidepressant effect of the intravenous infusion of a subanesthetic dose of ketamine in 2000 has triggered research endeavors in this novel mechanism of action (). Its drug abuse...
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Pierre Blier,
Daniel Zigman,
Jean Blier
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Correspondence
(In Press Corrected Proof)
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13 April 2012 |
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Lesions of Ventrolateral Prefrontal or Anterior Orbitofrontal Cortex in Primates Heighten Negative Emotion
DOI: 10.1016/j.biopsych.2012.03.007
Background: Heightened fear and anxiety are core symptoms of a variety of neuropsychiatric disorders. They are associated with structural and activity changes throughout neural circuitry that includes...
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Carmen Agustín-Pavón,
Katrin Braesicke,
Yoshiro Shiba,
Andrea M. Santangelo,
Yevheniia Mikheenko,
Gemma Cockroft,
Faaiza Asma,
Hannah Clarke,
Mei-See Man,
Angela C. Roberts
et al.
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Full-length article
(In Press Corrected Proof)
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13 April 2012 |
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Clustering of Depression and Inflammation in Adolescents Previously Exposed to Childhood Adversity
DOI: 10.1016/j.biopsych.2012.02.034
Background: There is mounting interest in the hypothesis that inflammation contributes to the pathogenesis of depression and underlies depressed patients' vulnerability to comorbid medical conditions....
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Gregory E. Miller,
Steve W. Cole
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Full-length article
(In Press Corrected Proof)
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12 April 2012 |
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Interplay of Maternal Care and Genetic Influences in Programming Adult Hippocampal Neurogenesis
DOI: 10.1016/j.biopsych.2012.03.001
Background: Adult hippocampal neurogenesis, which is involved in the physiopathology of hippocampal functions, is genetically determined and influenced by early life events. However, studies on the in...
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Muriel Koehl,
Rixt van der Veen,
Delphine Gonzales,
Pier Vincenzo Piazza,
Djoher Nora Abrous
et al.
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Full-length article
(In Press Corrected Proof)
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09 April 2012 |
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Exofocal Dopaminergic Degeneration as Antidepressant Target in Mouse Model of Poststroke Depression
DOI: 10.1016/j.biopsych.2012.02.026
Background: Although poststroke depression (PSD) is a frequent chronic complication of stroke with high relevance for outcome and survival, underlying pathomechanisms remain inadequately understood. T...
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Golo Kronenberg,
Mustafa Balkaya,
Vincent Prinz,
Karen Gertz,
Shengbo Ji,
Imke Kirste,
Isabella Heuser,
Björn Kampmann,
Julian Hellmann-Regen,
Peter Gass,
Reinhard Sohr,
Rainer Hellweg,
Christian Waeber,
Georg Juckel,
Heide Hörtnagl,
Ralf Stumm,
Matthias Endres
et al.
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Full-length article
(In Press Corrected Proof)
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05 April 2012 |
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Molecular Tools and Approaches for Optogenetics
DOI: 10.1016/j.biopsych.2012.02.019
The mammalian brain poses a formidable challenge to the study and treatment of neuropsychiatric diseases, owing to the complex interaction of genetic, epigenetic, and circuit-level mechanisms underlyi...
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Yuan Mei,
Feng Zhang
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Review article
(In Press Corrected Proof)
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05 April 2012 |
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Brain-Derived Neurotrophic Factor in Patients with Chronic Hepatitis C: Beyond Neurotrophic Support
DOI: 10.1016/j.biopsych.2012.02.036
Chronic hepatitis C (CHC) is frequently associated with neuropsychiatric syndromes, such as fatigue and depression (). The frequency of depressive syndromes also tends to increase during CHC standard ...
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Bruno Cópio Fábregas,
Aline Silva de Miranda,
Izabela Guimarães Barbosa,
Alexandre Sampaio Moura,
Ricardo Andrade Carmo,
Antonio Lucio Teixeira
et al.
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Correspondence
(In Press Corrected Proof)
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29 March 2012 |
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Regional Brain Structural Dysmorphology in Human Immunodeficiency Virus Infection: Effects of Acquired Immune Deficiency Syndrome, Alcoholism, and Age
DOI: 10.1016/j.biopsych.2012.02.018
Background: Human immunodeficiency virus (HIV) infection and alcoholism each carries liability for disruption of brain structure and function integrity. Despite considerable prevalence of HIV-alcoholi...
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Adolf Pfefferbaum,
Margaret J. Rosenbloom,
Stephanie A. Sassoon,
Carol A. Kemper,
Stanley Deresinski,
Torsten Rohlfing,
Edith V. Sullivan
et al.
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Full-length article
(In Press Corrected Proof)
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29 March 2012 |
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The Role of Ghrelin in Reward-Based Eating
DOI: 10.1016/j.biopsych.2012.02.016
The peptide hormone ghrelin acts in the central nervous system as a potent orexigenic signal. Not only is ghrelin recognized as playing an important role in feeding circuits traditionally thought of a...
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Mario Perelló,
Jeffrey M. Zigman
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Review article
(In Press Corrected Proof)
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29 March 2012 |
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Cerebrospinal Fluid Substance P-Like Immunoreactivity Correlates with Aggression in Personality Disordered Subjects
DOI: 10.1016/j.biopsych.2012.02.023
Background: Neurochemical studies have pointed to a modulatory role in human aggression for a variety of central neurotransmitters; some seem to play an inhibitory role, whereas others seem to play a ...
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Emil F. Coccaro,
Royce Lee,
Michael J. Owens,
Becky Kinkead,
Charles B. Nemeroff
et al.
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Full-length article
(In Press Corrected Proof)
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27 March 2012 |
