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A brief summary of the articles appearing in this issue of Biological Psychiatry
In this double-blind, randomized, crossover study, Zarate et al. (pages 939–946) sought to replicate prior findings of a rapid antidepressant response to ketamine in bipolar depression. They administe...
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931
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Enhancing Prolonged Exposure Therapy for Posttraumatic Stress Disorder with D-Cycloserine: Further Support for Treatments That Promote Experience-Dependent Neuroplasticity
Posttraumatic stress disorder (PTSD) is a common, distressing, and debilitating consequence of the experience of extremely stressful life events, exemplified by combat, sexual assault, torture, or nat...
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John H. Krystal
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932-934
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Translating the Rosetta Stone of N-Acetylcysteine
The history of the field of biological psychiatry can be cynically encapsulated by the quest to reverse engineer serendipitous clinical findings. The role of monoamines in depression, dopamine in schi...
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Olivia M. Dean,
Ashley I. Bush,
Michael Berk
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935-936
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N-Acetylcysteine for the Treatment of Glutathione Deficiency and Oxidative Stress in Schizophrenia
Despite decades of intense research and development, current treatments for schizophrenia (SZ) have not only met with limited efficacy but are also often associated with serious side effects, justifyi...
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Dikoma C. Shungu
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937-938
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| Priority Communication |
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Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial
02 February 2012
Background: Currently, no pharmacological treatments for bipolar depression exist that exert rapid (within hours) antidepressant or antisuicidal effects. We previously reported that intravenous admini...
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Carlos A. Zarate,
Nancy E. Brutsche,
Lobna Ibrahim,
Jose Franco-Chaves,
Nancy Diazgranados,
Anibal Cravchik,
Jessica Selter,
Craig A. Marquardt,
Victoria Liberty,
David A. Luckenbaugh
et al.
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939-946
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| Review |
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D-Cycloserine Effects on Extinction of Conditioned Responses to Drug-Related Cues
D-cycloserine (DCS) is an N-methyl-D-aspartate (NMDA) receptor partial agonist that facilitates extinction of conditioned fear in animals and cue exposure therapy (CET) for fear and anxiety disorders ...
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Karyn M. Myers,
William A. Carlezon
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947-955
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A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism
20 February 2012
Background: An imbalance in the excitatory/inhibitory systems with abnormalities in the glutamatergic pathways has been implicated in the pathophysiology of autism. Furthermore, chronic redox imbalanc...
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Antonio Y. Hardan,
Lawrence K. Fung,
Robin A. Libove,
Tetyana V. Obukhanych,
Surekha Nair,
Leonore A. Herzenberg,
Thomas W. Frazier,
Rabindra Tirouvanziam
et al.
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956-961
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A Randomized Placebo-Controlled Trial of d-Cycloserine to Enhance Exposure Therapy for Posttraumatic Stress Disorder
05 April 2012
Background: Posttraumatic stress disorder (PTSD) is a complex and debilitating anxiety disorder, and, although prolonged exposure therapy has been proven effective, many patients remain symptomatic af...
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Rianne A. de Kleine,
Gert-Jan Hendriks,
Wendy J.C. Kusters,
Theo G. Broekman,
Agnes van Minnen
et al.
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962-968
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Glutamatergic Modulation of Auditory Information Processing in the Human Brain
31 October 2011
Background: Auditory mismatch negativity (MMN) and P300 event-related potentials (ERPs) are reduced in schizophrenia patients and healthy volunteers administered the N-methyl-D-aspartate glutamate rec...
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Handan Gunduz-Bruce,
Robert M.G. Reinhart,
Brian J. Roach,
Ralitza Gueorguieva,
Stephen Oliver,
Deepak C. D'Souza,
Judith M. Ford,
John H. Krystal,
Daniel H. Mathalon
et al.
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969-977
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The Effect of N-Acetylcysteine in the Nucleus Accumbens on Neurotransmission and Relapse to Cocaine
05 December 2011
Background: Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) af...
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Yonatan M. Kupchik,
Khaled Moussawi,
Xing-Chun Tang,
Xiusong Wang,
Benjamin C. Kalivas,
Rosalia Kolokithas,
Katelyn B. Ogburn,
Peter W. Kalivas
et al.
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978-986
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Differential Role of NR2A and NR2B Subunits in N-Methyl-D-Aspartate Receptor Antagonist-Induced Aberrant Cortical Gamma Oscillations
07 November 2011
Background: N-methyl-D-aspartate receptor (NMDA-R) hypofunction plays an important role in cognitive impairment in schizophrenia. NMDA-R antagonists elicit psychotic symptoms in humans and schizophren...
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Bernat Kocsis
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987-995
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Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex
31 October 2011
Background: Knock-in mice with the common human brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have impaired trafficking of BDNF messenger RNA to dendrites. It was hypothesized, given ...
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Rong-Jian Liu,
Francis S. Lee,
Xiao-Yuan Li,
Francis Bambico,
Ronald S. Duman,
George K. Aghajanian
et al.
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996-1005
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N-Acetylcysteine Normalizes Neurochemical Changes in the Glutathione-Deficient Schizophrenia Mouse Model During Development
27 September 2011
Background: Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used...
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Joao Miguel das Neves Duarte,
Anita Kulak,
Mehdi Mohammad Gholam-Razaee,
Michel Cuenod,
Rolf Gruetter,
Kim Quang Do
et al.
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1006-1014
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Translational Magnetic Resonance Spectroscopy Reveals Excessive Central Glutamate Levels During Alcohol Withdrawal in Humans and Rats
12 September 2011
Background: In alcoholism, excessive glutamatergic neurotransmission has long been implicated in the acute withdrawal syndrome and as a key signal for dependence-related neuroplasticity. Our understan...
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Derik Hermann,
Wolfgang Weber-Fahr,
Alexander Sartorius,
Mareen Hoerst,
Ulrich Frischknecht,
Nuran Tunc-Skarka,
Stephanie Perreau-Lenz,
Anita C. Hansson,
Bertram Krumm,
Falk Kiefer,
Rainer Spanagel,
Karl Mann,
Gabriele Ende,
Wolfgang H. Sommer
et al.
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1015-1021
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| Techniques and Methods |
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1H-[13C]-Nuclear Magnetic Resonance Spectroscopy Measures of Ketamine's Effect on Amino Acid Neurotransmitter Metabolism
12 December 2011
Ketamine has recently gained significant attention owing to its psychotomimetic and more recently discovered rapid antidepressant-like properties. 1H-[13C]-nuclear magnetic resonance studies were empl...
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Golam M.I. Chowdhury,
Kevin L. Behar,
William Cho,
Monique A. Thomas,
Douglas L. Rothman,
Gerard Sanacora
et al.
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1022-1025
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| Correspondence |
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Is Deep Brain Stimulation Able to Make Antidepressants Effective in Resistant Obsessive-Compulsive Disorder?
24 November 2011
Deep brain stimulation (DBS), a nonablative, reversible, and adjustable neurosurgical procedure, has recently been considered as a potential therapeutic alternative for the management of resistant obs...
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Bruno Aouizerate,
Emmanuel Cuny,
Jean-Yves Rotgé,
Corinne Martin-Guehl,
Olivier Doumy,
Abdelhamid Benazzouz,
Michele Allard,
Alain Rougier,
Bernard Bioulac,
Jean Tignol,
Dominique Guehl,
Pierre Burbaud
et al.
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e43-e44
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Editorial Board
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Subscribers Page
Biological Psychiatry (ISSN 0006-3223) is published semimonthly by Elsevier Inc., 360 Park Avenue South, New York, NY 10010-1710. Periodicals postage paid at New York, NY and additional mailing office...
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Table of Contents
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Guide for Authors
Biological Psychiatry is the official journal of the Society of Biological Psychiatry. The Journal rapidly publishes reports of novel results on a broad range of topics related to the pathophysiology ...
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A5-A6
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Manuscript Submission Form
This form should be completed by every author and accompany every new manuscript submission. It must be fully complete and accurate, with signatures from ALL authors, before a manuscript can be finali...
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