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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Decreased carbonyl reductase 1 expression promotes malignant behaviours by induction of epithelial mesenchymal transition and its clinical significance
DOI: 10.1016/j.canlet.2012.03.035
Abstract: Human carbonyl reductase 1 (CBR1) is an enzyme that catalyse the reduction of many compounds by using NADPH-dependent oxydoreductase activity. Although CBR1 is known to regulate the tumour p...
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Akihiro Murakami,
Kazuyuki Yakabe,
Keiko Yoshidomi,
Kotaro Sueoka,
Shugo Nawata,
Yoshihito Yokoyama,
Shigeki Tsuchida,
Fahd Al-Mulla,
Norihiro Sugino
et al.
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Full-length article
(In Press Corrected Proof)
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22 May 2012 |
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Oxidatively generated complex DNA damage: Tandem and clustered lesions
DOI: 10.1016/j.canlet.2012.04.005
Abstract: There is an increasing interest for oxidatively generated complex lesions that are potentially more detrimental than single oxidized nucleobases. In this survey, the recently available infor...
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Jean Cadet,
Jean-Luc Ravanat,
Marisa TavernaPorro,
Hervé Menoni,
Dimitar Angelov
et al.
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Short survey
(In Press Corrected Proof)
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21 May 2012 |
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miR-409-3p inhibits HT1080 cell proliferation, vascularization and metastasis by targeting angiogenin
DOI: 10.1016/j.canlet.2012.04.010
Abstract: Although the expression of angiogenin (ANG), an angiogenic and tumorigenic factor, is elevated in various types of cancers, its regulation mechanism remains unclear. In the present study, in...
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Chunhua Weng,
Haojie Dong,
Guangdi Chen,
Yixing Zhai,
Rongpan Bai,
Hu Hu,
Linrong Lu,
Zhengping Xu
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells
DOI: 10.1016/j.canlet.2012.04.022
Abstract: In this study we present the effects of nilotinib and dasatinib on telomerase activity and regulation. Nilotinib and dasatinib strongly reduced telomerase activity in BCR-ABL-positive (K562)...
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Saar Shapira,
Galit Granot,
Rahav Mor-Tzuntz,
Pia Raanani,
Orit Uziel,
Meir Lahav,
Ofer Shpilberg
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Breast cancer stem cells: Obstacles to therapy
DOI: 10.1016/j.canlet.2012.04.023
Abstract: Only a fraction of the cells in a breast tumour are able to seed new tumour growth. These so-called breast cancer stem cells (bCSCs) are characterised by a number of discrete functional prop...
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Matthew Smalley,
Luke Piggott,
Richard Clarkson
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Short survey
(In Press Corrected Proof)
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21 May 2012 |
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Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells
DOI: 10.1016/j.canlet.2012.04.012
Abstract: Cathepsin D (CatD), a lysosomal aspartic protease, plays an essential role in tumor progression and apoptosis. However, the function of CatD in cell death is not yet fully understood. In thi...
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Young-Sool Hah,
Hae Sook Noh,
Ji Hye Ha,
Jin Sook Ahn,
Jong Ryeal Hahm,
Hee Young Cho,
Deok Ryong Kim
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Estrogen receptor positive breast cancer identified by 95-gene classifier as at high risk for relapse shows better response to neoadjuvant chemotherapy
DOI: 10.1016/j.canlet.2012.04.017
Abstract: A 95-gene classifier (95-GC) recently developed by us can predict the risk of relapse for ER-positive and node-negative breast cancer patients with high accuracy. This study investigated ass...
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Ryo Tsunashima,
Yasuto Naoi,
Kazuki Kishi,
Yosuke Baba,
Atsushi Shimomura,
Naomi Maruyama,
Takahiro Nakayama,
Kenzo Shimazu,
Seung Jin Kim,
Yasuhiro Tamaki,
Shinzaburo Noguchi
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Epigenetic biomarkers in lung cancer
DOI: 10.1016/j.canlet.2012.04.018
Abstract: Lung cancer mortality is strongly associated with the predominant diagnosis of late stage lesions that hampers effective therapy. Molecular biomarkers for early lung cancer detection is an u...
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Triantafillos Liloglou,
Naiara G. Bediaga,
Benjamin R.B. Brown,
John K. Field,
Michael P.A. Davies
et al.
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Short survey
(In Press Corrected Proof)
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21 May 2012 |
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MicroRNA-19a and -19b regulate cervical carcinoma cell proliferation and invasion by targeting CUL5
DOI: 10.1016/j.canlet.2012.02.038
Abstract: MicroRNAs (miRNAs) play a key role in the regulation of gene expression. In this study, we demonstrate that microRNA-19a and -19b (miR-19a/b) are highly expressed in human cervical cancer ce...
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Xue-Mei Xu,
Xiao-Bo Wang,
Miao-Miao Chen,
Tao Liu,
Yi-Xuan Li,
Wei-Hua Jia,
Min Liu,
Xin Li,
Hua Tang
et al.
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Full-length article
(In Press Corrected Proof)
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21 May 2012 |
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Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors
DOI: 10.1016/j.canlet.2012.04.024
Abstract: Dendritic cell (DC)-mediated immunotherapy has not been as effective as expected for most solid tumors. This study demonstrates immune responses against solid tumors mediated by DCs charged ...
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Nam-Chul Jung,
Hee Jung Kim,
Mi-Sun Kang,
Jun-Ho Lee,
Jie-Young Song,
Han Geuk Seo,
Yong-Soo Bae,
Dae-Seog Lim
et al.
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Full-length article
(In Press Corrected Proof)
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18 May 2012 |
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Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo
DOI: 10.1016/j.canlet.2012.03.036
Abstract: Epigenetic upregulation of voltage-gated sodium channels (VGSCs) has been reported in a number of carcinoma cell lines and tissues. Furthermore, a large body of experimental evidence suggest...
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Senay Yildirim,
Seyhan Altun,
Hatice Gumushan,
Anup Patel,
Mustafa B.A. Djamgoz
et al.
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Full-length article
(In Press Corrected Proof)
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17 May 2012 |
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Statins and cancer: Current and future prospects
DOI: 10.1016/j.canlet.2012.04.011
Abstract: Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects beyond cholesterol reduction, including anticancer activity. This review presents the effects of ...
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Maja Osmak
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Short survey
(In Press Corrected Proof)
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17 May 2012 |
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Translating TRAIL-receptor targeting agents to the clinic
DOI: 10.1016/j.canlet.2012.04.007
Abstract: The extrinsic apoptotic pathway can be activated by the endogenous ligand TRAIL (Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand) by binding to the death receptors TRAIL-R1 and...
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Martha W. den Hollander,
Jourik A. Gietema,
Steven de Jong,
Annemiek M.E. Walenkamp,
Anna K.L. Reyners,
Corina N.A.M. Oldenhuis,
Elisabeth G.E. de Vries
et al.
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Short survey
(In Press Corrected Proof)
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17 May 2012 |
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Epigenetics in human gliomas
DOI: 10.1016/j.canlet.2012.04.008
Abstract: Aberrant epigenetic landscapes and their involvement in genesis and progression of tumors, as well as in treatment responses and prognosis, indicate one of the most emerging fields in cancer...
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Simone Kreth,
Niklas Thon,
Friedrich W. Kreth
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Short survey
(In Press Corrected Proof)
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16 May 2012 |
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Incretins and thiazolidinediones in glucose homeostasis and cancer: Role of common polymorphisms
DOI: 10.1016/j.canlet.2012.04.002
Abstract: With growing epidemiologic and molecular evidence linking the pathogenesis of diabetes mellitus and oncogenesis, the role of anti-diabetic drugs as antineoplastic agents becomes a subject of...
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Shitij Arora,
Anurag Mehrotra,
Subhash C. Gulati
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Short survey
(In Press Corrected Proof)
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14 May 2012 |
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Interleukin-12 inhibits the survival of human colon cancer stem cells in vitro and their tumor initiating capacity in mice
DOI: 10.1016/j.canlet.2012.02.015
Abstract: Interleukin-12 (IL-12) is a potent immunomodulatory cytokine with unknown direct effect on the property of cancer stem cells (CSCs). In this study, we investigated the capacity of IL-12 to r...
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Xiao-ling Yin,
Ning Wang,
Xing Wei,
Gan-feng Xie,
Jian-jun Li,
Hou-jie Liang
et al.
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Full-length article
(In Press Corrected Proof)
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14 May 2012 |
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Colon cancer stem cells – From basic to clinical application
DOI: 10.1016/j.canlet.2012.04.006
Abstract: Based on cancer stem cell (CSC) concept of carcinogenesis, tumors represent complex heterogeneous organ-like systems with a hierarchical cellular organization, and only minority phenotypic s...
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Galina Botchkina
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Short survey
(In Press Corrected Proof)
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14 May 2012 |
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Ovarian cancer stem cell markers: Prognostic and therapeutic implications
DOI: 10.1016/j.canlet.2012.02.002
Abstract: Cancer stem cells are rare chemotherapy resistant cells within a tumor which can serve to populate the bulk of a tumor with more differentiated daughter cells and potentially contribute to r...
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Daniela Burgos-Ojeda,
Bo R. Rueda,
Ronald J. Buckanovich
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Short survey
(In Press Corrected Proof)
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09 May 2012 |
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Regulation of thrombomodulin expression in prostate cancer cells
DOI: 10.1016/j.canlet.2012.03.001
Abstract: In carcinomas the expression of thrombomodulin (TM) is inversely correlated with tumour progression and metastasis. In the present study a decreased TM expression in human prostate cancer ce...
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Mario Menschikowski,
Albert Hagelgans,
Oliver Tiebel,
Margot Vogel,
Graeme Eisenhofer,
Gabriele Siegert
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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HPV DNA, E6*I-mRNA expression and p16INK4A immunohistochemistry in head and neck cancer – How valid is p16INK4A as surrogate marker?
DOI: 10.1016/j.canlet.2012.03.033
Abstract: It has been proposed that p16INK4A qualifies as a surrogate marker for viral oncogene activity in head and neck cancer (HNSCC). By analyzing 78 HNSCC we sought to validate the accuracy of p1...
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Markus Hoffmann,
Silke Tribius,
Elgar Susanne Quabius,
Hannes Henry,
Saskia Pfannenschmidt,
Claudia Burkhardt,
Tibor Görögh,
Gordana Halec,
Anna Sophie Hoffmann,
Tomas Kahn,
Christoph Röcken,
Jochen Haag,
Tim Waterboer,
Markus Schmitt
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Breast cancer, side population cells and ABCG2 expression
DOI: 10.1016/j.canlet.2012.03.041
Abstract: Recurrent metastatic breast cancer may arise in part due to the presence of drug resistant adult stem cells such as Side Population (SP) cells, whose phenotype has been demonstrated to be du...
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K.M. Britton,
R. Eyre,
I.J. Harvey,
K. Stemke-Hale,
D. Browell,
T.W.J. Lennard,
A.P. Meeson
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases
DOI: 10.1016/j.canlet.2012.04.001
Abstract: Patients with castration-resistant prostate cancer (CRPC) frequently have metastases to the bone, which may cause pain and lead to a deterioration in quality-of-life. Bone-seeking radiopharm...
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Jatinder Goyal,
Emmanuel S. Antonarakis
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Short survey
(In Press Corrected Proof)
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07 May 2012 |
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DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors
DOI: 10.1016/j.canlet.2012.04.003
Abstract: IL-6 is a multifunctional cytokine that is important for immune responses, cell survival, apoptosis, and proliferation. However, little is known about the correlation between the IL-6 signal...
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Un Jung Yun,
Sang Eun Park,
Yong Sam Jo,
Jungbin Kim,
Deug Y. Shin
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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NOP14 promotes proliferation and metastasis of pancreatic cancer cells
DOI: 10.1016/j.canlet.2012.03.010
Abstract: Pancreatic cancer (PC) is one of the most malignant cancers worldwide. We describe a novel gene, NOP14, which plays significant roles in PC cell proliferation and migration. Inhibition or ov...
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Bin Zhou,
Qiao Wu,
Ge Chen,
Tai-Ping Zhang,
Yu-Pei Zhao
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Characterization of sphere-forming cells with stem-like properties from the small cell lung cancer cell line H446
DOI: 10.1016/j.canlet.2012.04.004
Abstract: A relatively novel paradigm in tumor biology hypothesizes that cancer growth is driven by tumor cells with stem-like properties. However, direct proof of a population of stem cells in small ...
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Xiaofei Qiu,
Zhengyan Wang,
Yanlei Li,
Yajing Miao,
Yu Ren,
Yajing Luan
et al.
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Full-length article
(In Press Corrected Proof)
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07 May 2012 |
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Development of a novel approach, the epigenome-based outlier approach, to identify tumor-suppressor genes silenced by aberrant DNA methylation
DOI: 10.1016/j.canlet.2012.03.016
Abstract: Identification of tumor-suppressor genes (TSGs) silenced by aberrant methylation of promoter CpG islands (CGIs) is important, but hampered by a large number of genes methylated as passengers...
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Mizuho Kikuyama,
Hideyuki Takeshima,
Takayuki Kinoshita,
Eriko Okochi-Takada,
Mika Wakabayashi,
Sadako Akashi-Tanaka,
Toshihisa Ogawa,
Yasuyuki Seto,
Toshikazu Ushijima
et al.
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Full-length article
(In Press Corrected Proof)
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04 May 2012 |
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Bax345/BLyS: A novel, completely human fusion protein targeting malignant B cells and delivering a unique mitochondrial toxin
DOI: 10.1016/j.canlet.2012.02.029
Abstract: We generated a fusion protein Bax345/BLyS containing the truncated form of Bax (Bax345) at the N-terminus followed by a 218 linker to the B lymphocyte stimulator (BLyS). Bax345/BLyS was cyto...
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Mi-Ae Lyu,
Lawrence H. Cheung,
Walter N. Hittelman,
Yuying Liu,
John W. Marks,
Min-Jeong Cho,
Michael G. Rosenblum
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Insulin promotes proliferation, survival, and invasion in endometrial carcinoma by activating the MEK/ERK pathway
DOI: 10.1016/j.canlet.2012.03.026
Abstract: The involvement of insulin in endometrial carcinoma (EC) was investigated using radioimmunoassay, Western blot, immunoprecipitation, MTT, and Annexin V-FITC/PI assays in tissue samples and c...
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Yingmei Wang,
Yuanxi Zhu,
Lizhi Zhang,
Wenyan Tian,
Shaofang Hua,
Jing Zhao,
Huiying Zhang,
Fengxia Xue
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Gambogenic acid induces G1 arrest via GSK3β-dependent cyclin D1 degradation and triggers autophagy in lung cancer cells
DOI: 10.1016/j.canlet.2012.03.004
Abstract: Cyclin D1, an oncogenic G1 cyclin which can be induced by environmental carcinogens and whose over-expression may cause dysplasia and carcinoma, has been shown to be a target for cancer chem...
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Xian-Jun Yu,
Quan-Bin Han,
Zhe-Sheng Wen,
Liang Ma,
Jin Gao,
Guang-Biao Zhou
et al.
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Full-length article
(In Press Corrected Proof)
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30 April 2012 |
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Crosstalk between NFkB and glucocorticoid signaling: A potential target of breast cancer therapy
DOI: 10.1016/j.canlet.2012.02.033
Abstract: Breast cancer (BC) is an aggressive and high mortality cancer that can be classified into five molecular subtypes, based on gene expression profiling. The extreme heterogeneity poses difficu...
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Jun Ling,
Raj Kumar
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Short survey
(In Press Corrected Proof)
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30 April 2012 |
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Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism
DOI: 10.1016/j.canlet.2012.03.031
Abstract: Pancreatic tumors are resistant to conventional chemotherapies. The present study was aimed at evaluating the potential of a novel plant-derived product as a therapeutic agent for pancreatic...
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María P. Torres,
Satyanarayana Rachagani,
Vinee Purohit,
Poomy Pandey,
Suhasini Joshi,
Erik D. Moore,
Sonny L. Johansson,
Pankaj K. Singh,
Apar K. Ganti,
Surinder K. Batra
et al.
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Full-length article
(In Press Corrected Proof)
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27 April 2012 |
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Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy
DOI: 10.1016/j.canlet.2012.03.030
Abstract: Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer. The 2-year survival rate of patients with stage III or IV disease is only about 50%. Due to its high radiosensitivity, radiother...
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Lu Zhang,
Lifang Yang,
Jian Jian Li,
Lunquan Sun
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Short survey
(In Press Corrected Proof)
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27 April 2012 |
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Tissue inhibitor of metalloproteinases in oral squamous cell carcinomas – A therapeutic target?
DOI: 10.1016/j.canlet.2012.03.040
Abstract: Matrix metalloproteinases (MMPs) are proteases responsible for remodeling the extracellular matrix (ECM) and enabling spreading and metastasis of tumor cells, a common phenomenon in oral squ...
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Mario Pérez-Sayáns García,
José Manuel Suárez-Peñaranda,
Pilar Gayoso-Diz,
Francisco Barros-Angueira,
José Manuel Gándara-Rey,
Abel García-García
et al.
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Short survey
(In Press Corrected Proof)
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26 April 2012 |
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Sphere formation reverses the metastatic and cancer stem cell phenotype of the murine mammary tumour 4T1, independently of the putative cancer stem cell marker Sca-1
DOI: 10.1016/j.canlet.2012.03.028
Abstract: Breast cancer stem cells (BCSCs) initiate and sustain breast cancers, and several putative markers have been proposed to prospectively isolate BCSC from the non-cancer stem cell population. ...
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Heli Matilainen,
Xiao-Wen Yu,
Ching-Wen Tang,
Michael V. Berridge,
Melanie J. McConnell
et al.
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Full-length article
(In Press Corrected Proof)
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26 April 2012 |
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Oxidative stress, DNA damage and repair in carcinogenesis: Have we established a connection?
DOI: 10.1016/j.canlet.2012.03.032
Abstract: The production of a plethora of reactive oxygen and nitrogen species in the cell and tissues as the result of endogenous or exogenous mechanisms and interaction of our cells with the environ...
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Alexandros G. Georgakilas
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Editorial
(In Press Corrected Proof)
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25 April 2012 |
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Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma
DOI: 10.1016/j.canlet.2012.03.042
Abstract: Nasopharyngeal carcinoma (NPC) is endemic in southern China. In a genome-wide screen for genes inactivated by promoter hypermethylation, we identified Ras-related associated with diabetes (R...
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Yingxi Mo,
Kaoru Midorikawa,
Zhe Zhang,
Xiaoying Zhou,
Ning Ma,
Guangwu Huang,
Yusuke Hiraku,
Shinji Oikawa,
Mariko Murata
et al.
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Full-length article
(In Press Corrected Proof)
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25 April 2012 |
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How to treat CML patients in the tyrosine kinase inhibitors era? From imatinib standard dose to second generation drugs front-line: Unmet needs, pitfalls and advantages
DOI: 10.1016/j.canlet.2012.03.021
Highlights: ► At the last follow-up of IRIS trial, about 40% of patients did not reach a favorable result. ► High dose imatinib or association with IFN did not improve the results of standard dose ima...
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Massimo Breccia,
Giuliana Alimena
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Short survey
(In Press Corrected Proof)
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25 April 2012 |
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Road to early detection of pancreatic cancer: Attempts to utilize epigenetic biomarkers
DOI: 10.1016/j.canlet.2012.03.022
Abstract: The prognosis of pancreatic cancer is extremely poor, mainly because of its aggressive biological behavior and late onset of symptoms for clinical diagnosis; these impose limitations on ther...
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Shinichi Fukushige,
Akira Horii
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Short survey
(In Press Corrected Proof)
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25 April 2012 |
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Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner
DOI: 10.1016/j.canlet.2012.03.038
Abstract: Mitochondrial fusion and fission are dynamically regulated during apoptotic cell death, and mitofusin (Mfn) and related proteins have been shown to be involved in apoptosis-associated change...
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Seung-Wook Ryu,
Kyungsun Choi,
Jong-Hwan Park,
Yeong-Min Park,
Sunchang Kim,
Chulhee Choi
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Genistein inhibits the stemness properties of prostate cancer cells through targeting Hedgehog–Gli1 pathway
DOI: 10.1016/j.canlet.2012.03.037
Abstract: Cancer stem cells (CSCs) are involved in tumorigenesis and progression of prostate cancer (PCa). Conventional anticancer therapeutics failed to eradicate CSCs, which may eventually lead to t...
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Linlin Zhang,
Lei Li,
Min Jiao,
Dapeng Wu,
Kaijie Wu,
Xiang Li,
Guodong Zhu,
Lin Yang,
Xinyang Wang,
Jer-Tsong Hsieh,
Dalin He
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells
DOI: 10.1016/j.canlet.2012.02.020
Abstract: Ultrasound (US) has been shown to induce cell death in cancer cells; however, the underlying mechanism remains elusive. Here, we report a set of novel findings on the molecular mechanism. We...
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Yukihiro Furusawa,
Yoshisada Fujiwara,
Mariame Ali Hassan,
Yoshiaki Tabuchi,
Akinori Morita,
Atsushi Enomoto,
Takashi Kondo
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway
DOI: 10.1016/j.canlet.2012.02.035
Abstract: In our previous study, we found that blockade of SDF-1/CXCR4 signaling inhibits pancreatic cancer cell migration and invasion in vitro. However, the mechanism governing the downstream regula...
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Xuqi Li,
Qingyong Ma,
Qinhong Xu,
Han Liu,
Jianjun Lei,
Wanxing Duan,
Kruttika Bhat,
Fengfei Wang,
Erxi Wu,
Zheng Wang
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells
DOI: 10.1016/j.canlet.2012.02.032
Abstract: Ser/Thr protein kinase CK2 regulates multiple processes that play important roles in the sensitivity of cancer to epidermal growth factor receptor targeting therapeutics, including PI3K-Akt-...
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Joshua Bliesath,
Nanni Huser,
Mayuko Omori,
Daniel Bunag,
Chris Proffitt,
Nicole Streiner,
Caroline Ho,
Adam Siddiqui-Jain,
Sean E. O’Brien,
John K.C. Lim,
David M. Ryckman,
Kenna Anderes,
William G. Rice,
Denis Drygin
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3
DOI: 10.1016/j.canlet.2012.03.029
Abstract: The phosphatase of regenerating liver-3 (PRL-3) gene is associated with metastasis in gastric cancer, and is believed to play a causative role by promoting tumor cell motility, invasion, and...
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Zhengrong Li,
Yi Cao,
Zhigang Jie,
Yi Liu,
Yingliang Li,
Junhe Li,
Guoming Zhu,
Zhengren Liu,
Yi Tu,
Gen Peng,
Dong-woo Lee,
Sung-soo Park
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Overcoming acquired resistance to letrozole by targeting the PI3K/AKT/mTOR pathway in breast cancer cell clones
DOI: 10.1016/j.canlet.2012.03.034
Abstract: Development of resistance to endocrine therapy is a clinical issue in estrogen receptor (ER)-positive breast cancer. Here we show that persistent activation of AKT/mTOR signaling is crucial ...
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Andrea Cavazzoni,
Mara A. Bonelli,
Claudia Fumarola,
Silvia La Monica,
Kinda Airoud,
Ramona Bertoni,
Roberta R. Alfieri,
Maricla Galetti,
Stefano Tramonti,
Elena Galvani,
Adrian L. Harris,
Lesley-Ann Martin,
Daniele Andreis,
Alberto Bottini,
Daniele Generali,
Pier Giorgio Petronini
et al.
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Full-length article
(In Press Corrected Proof)
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23 April 2012 |
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Immunity and malignant mesothelioma: From mesothelial cell damage to tumor development and immune response-based therapies
DOI: 10.1016/j.canlet.2012.02.034
Abstract: Malignant mesothelioma (MM) is a cancer with a high mortality rate and limited therapeutic options, typically presenting as a tumor in the serous membranes, most frequently in the pleura and...
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Valerio Izzi,
Laura Masuelli,
Ilaria Tresoldi,
Calogero Foti,
Andrea Modesti,
Roberto Bei
et al.
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Short survey
(In Press Corrected Proof)
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23 April 2012 |
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Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway
DOI: 10.1016/j.canlet.2012.03.039
Abstract: Multidrug resistance (MDR) represents a major obstacle in the successful treatment of breast cancer. The MDR1 gene is a direct target of the Wnt/β-catenin signaling pathway, which controls t...
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Hui Zhang,
Xiaofang Zhang,
Xiaojuan Wu,
Weiwei Li,
Peng Su,
Hongxia Cheng,
Lei Xiang,
Peng Gao,
Gengyin Zhou
et al.
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Full-length article
(In Press Corrected Proof)
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20 April 2012 |
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Synergistic antitumor efficacy of sequentially combined paclitaxel with sorafenib in vitro and in vivo NSCLC models harboring KRAS or BRAF mutations
DOI: 10.1016/j.canlet.2012.03.015
Abstract: Studies on non-small cell lung cancer (NSCLC) patients with KRAS or BRAF mutations are urgently needed to improve clinical outcomes. We evaluated the cytotoxicities of paclitaxel and sorafen...
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Xiang-Hua Zhang,
Jung-Young Shin,
Jeong-Oh Kim,
Ji-Eun Oh,
Seong-Ae Yoon,
Chan-Kwon Jung,
Jin-Hyoung Kang
et al.
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Full-length article
(In Press Corrected Proof)
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20 April 2012 |
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Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori
DOI: 10.1016/j.canlet.2012.03.027
Abstract: TNF-α-inducing protein (Tipα) is a unique carcinogenic factor of Helicobacter pylori, which is secreted into culture broth. The biological activities of Tipα and deletion mutant were studied...
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Masami Suganuma,
Tatsuro Watanabe,
Kensei Yamaguchi,
Atsushi Takahashi,
Hirota Fujiki
et al.
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Short survey
(In Press Corrected Proof)
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19 April 2012 |
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Targeting a cornerstone of radiation resistance: Cancer stem cell
DOI: 10.1016/j.canlet.2012.03.024
Abstract: In radiation oncology, cancer stem cells (CSCs) have become an important research field. In fact, it appears that most cancer types contain populations of cells that exhibit stem-cell proper...
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Coralie Moncharmont,
Antonin Levy,
Marion Gilormini,
Gérald Bertrand,
Cyrus Chargari,
Gersende Alphonse,
Dominique Ardail,
Claire Rodriguez-Lafrasse,
Nicolas Magné
et al.
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Short survey
(In Press Corrected Proof)
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16 April 2012 |
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Featuring the Special Issue Editor: Associate Professor Alexandros G. Georgakilas
DOI: 10.1016/j.canlet.2012.03.012
Abstract: In this ‘Featuring the editor’ article, we introduce Assoc. Professor Alexandros G. Georgakilas as the guest editor for this Special Issue of Cancer Letters. His main research, educational a...
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Alexandros G. Georgakilas
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Short survey
(In Press Corrected Proof)
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09 April 2012 |
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Human breast and melanoma cancer stem cells biomarkers
DOI: 10.1016/j.canlet.2012.03.017
Abstract: Cancer progression in humans is difficult to infer because we do not routinely sample patients at multiple stages of their disease. The identification cancer stem cell (CSC) subpopulations i...
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Caterina A.M. La Porta,
Stefano Zapperi
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Short survey
(In Press Corrected Proof)
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09 April 2012 |
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Pancreatic cancer stem cells: Emerging target for designing novel therapy
DOI: 10.1016/j.canlet.2012.03.018
Abstract: In the past few years, there have been significant advances in the research on cancer stem cells (CSCs). The emerging evidences have demonstrated that CSCs and epithelial–mesenchymal transit...
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Yiwei Li,
Dejuan Kong,
Aamir Ahmad,
Bin Bao,
Fazlul H. Sarkar
et al.
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Short survey
(In Press Corrected Proof)
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09 April 2012 |
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Regulation of apoptosis pathways in cancer stem cells
DOI: 10.1016/j.canlet.2012.03.014
Abstract: Cancer stem cell are considered to represent a population within the bulk tumor that share many similarities to normal stem cells as far as their capacities to self-renew, differentiate, pro...
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Simone Fulda
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Short survey
(In Press Corrected Proof)
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09 April 2012 |
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Targeting survivin in cancer
DOI: 10.1016/j.canlet.2012.03.005
Abstract: With almost 4000 citations in Medline in a little over 10years, survivin has certainly kept scores of investigators busy worldwide. Tangible progress has been made in revealing the multiple ...
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Dario C. Altieri
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Short survey
(In Press Corrected Proof)
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09 April 2012 |
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HMGB-1 induces cell motility and α5β1 integrin expression in human chondrosarcoma cells
DOI: 10.1016/j.canlet.2012.02.014
Abstract: Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. High mobility group box chromosomal protein 1 (HMGB)-1 is a widely s...
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Chih-Hsin Tang,
Yun-Ting Keng,
Ju-Fang Liu
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Full-length article
(In Press Corrected Proof)
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30 March 2012 |
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Epigenetic biomarkers in esophageal cancer
DOI: 10.1016/j.canlet.2012.02.036
Abstract: The aberrant DNA methylation of tumor suppressor genes is well documented in esophageal cancer, including adenocarcinoma (EAC) and squamous cell carcinoma (ESCC) as well as in Barrett’s esop...
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Andrew M. Kaz,
William M. Grady
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Short survey
(In Press Corrected Proof)
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29 March 2012 |
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Pleiotrophic effects of natural products in ROS-induced carcinogenesis: The role of plant-derived natural products in oral cancer chemoprevention
DOI: 10.1016/j.canlet.2012.02.025
Abstract: Cancer is a multistage process where each stage involves different molecular, biochemical and cellular events all of which, however, contribute to malignant transformation. Over the last yea...
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Dominique Ziech,
Ioannis Anestopoulos,
Rania Hanafi,
Georgia Persephoni Voulgaridou,
Rodrigo Franco,
Alexandros G. Georgakilas,
Aglaia Pappa,
Mihalis I. Panayiotidis
et al.
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Short survey
(In Press Corrected Proof)
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29 March 2012 |
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Epigenetic biomarkers in prostate cancer: Current and future uses
DOI: 10.1016/j.canlet.2012.02.011
Abstract: Epigenome alterations are characteristic of nearly all human malignancies and include changes in DNA methylation, histone modifications and microRNAs (miRNAs). However, what induces these ep...
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Karen Chiam,
Carmela Ricciardelli,
Tina Bianco-Miotto
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Short survey
(In Press Corrected Proof)
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26 March 2012 |
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Delineating an epigenetic continuum in head and neck cancer
DOI: 10.1016/j.canlet.2012.02.018
Abstract: A tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. Genomic changes could be of potential use in the diagnosis and prognosis of pre-...
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Maria J. Worsham,
Josena K. Stephen,
Kang Mei Chen,
Shaleta Havard,
Veena Shah,
Glendon Gardner,
Vanessa G. Schweitzer
et al.
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Short survey
(In Press Corrected Proof)
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21 March 2012 |