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Editorial Board
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IFC
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Editorial Communication
Over 30 years have passed since the first issue of Cancer Genetics and Cytogenetics (CGC) was published in July 1979. This is the last issue of CGC. During that long journey, CGC has contributed to th...
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Avery A. Sandberg,
Aurelia M. Meloni-Ehrig,
Herman Van den Berghe,
Paola Dal Cin,
AnneMarie W. Block
et al.
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101
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| Reviews |
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Cytogenetics and genetics of human cancer: methods and accomplishments
Abstract: Cytogenetic and related changes in human cancer constitute part of a constantly developing and enlarging continuum of known genetic alterations associated with cancer development and biology...
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Avery A. Sandberg,
Aurelia M. Meloni-Ehrig
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102-126
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MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application
Abstract: Chronic lymphocytic leukemia (CLL) is the most common form of leukemia among adults in the Western world, with an incidence of approximately 1 out of 100,000 patients per year. CLL is charac...
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S. Patrick Nana-Sinkam,
Carlo M. Croce
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127-133
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| Original articles |
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Author(s) |
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Stimulation of chronic lymphocytic leukemia cells with CpG oligodeoxynucleotide gives consistent karyotypic results among laboratories: a CLL Research Consortium (CRC) Study
Abstract: Cytogenetic abnormalities are important prognostic indicators in CLL. Historically, only interphase cytogenetics was clinically useful in CLL, because traditional mitogens are not effective ...
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Nyla A. Heerema,
John C. Byrd,
Paola S. Dal Cin,
Marie L. Dell’ Aquila,
Prasad R.K. Koduru,
Ayala Aviram,
Stephanie A. Smoley,
Laura Z. Rassenti,
Andrew W. Greaves,
Jennifer R. Brown,
Kanti R. Rai,
Thomas J. Kipps,
Neil E. Kay,
Daniel L. Van Dyke,
Chronic Lymphocytic Leukemia Research Consortium
et al.
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134-140
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Standardization of fluorescence in situ hybridization studies on chronic lymphocytic leukemia (CLL) blood and marrow cells by the CLL Research Consortium
Abstract: Five laboratories in the Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) investigated standardizing and pooling of fluorescence in situ hybridization (FISH) results as a collabo...
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Stephanie A. Smoley,
Daniel L. Van Dyke,
Neil E. Kay,
Nyla A. Heerema,
Marie L. Dell’ Aquila,
Paola Dal Cin,
Prasad Koduru,
Ayala Aviram,
Laura Rassenti,
John C. Byrd,
Kanti R. Rai,
Jennifer R. Brown,
Andrew W. Greaves,
Jeanette Eckel-Passow,
Donna Neuberg,
Thomas J. Kipps,
Gordon W. Dewald
et al.
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141-148
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Gene dosage effects in chronic lymphocytic leukemia
Abstract: To understand the influence of chromosomal alterations on gene expression in a genome-wide view, chromosomal imbalances detected by single nucleotide polymorphism (SNP) chips were compared w...
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Ludger Sellmann,
Rene Scholtysik,
Markus Kreuz,
Sandra Cyrull,
Enrico Tiacci,
Jens Stanelle,
Alexander Carpinteiro,
Holger Nückel,
Tanja Boes,
Stefan Gesk,
Reiner Siebert,
Ludger Klein-Hitpass,
Ulrich Dührsen,
Jan Dürig,
Ralf Küppers
et al.
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149-160
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Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapy
Abstract: To better understand the implications of genomic instability and outcome in B-cell chronic lymphocytic leukemia (CLL), we sought to address genomic complexity as a predictor of chemosensitiv...
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Neil E. Kay,
Jeanette E. Eckel-Passow,
Esteban Braggio,
Scott VanWier,
Tait D. Shanafelt,
Daniel L. Van Dyke,
Diane F. Jelinek,
Renee C. Tschumper,
Thomas Kipps,
John C. Byrd,
Rafael Fonseca
et al.
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161-168
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Correlation of cytomorphology, immunophenotyping, and interphase fluorescence in situ hybridization in 381 patients with monoclonal gammopathy of undetermined significance and 301 patients with plasma cell myeloma
Abstract: To further clarify the transformation from monoclonal gammopathy of undetermined significance (MGUS) to plasma cell myeloma (PCM), we compared interphase fluorescence in situ hybridization (...
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Ulrike Bacher,
Torsten Haferlach,
Wolfgang Kern,
Tamara Alpermann,
Susanne Schnittger,
Claudia Haferlach
et al.
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169-175
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Examination of copy number variations of CHST9 in multiple types of hematologic malignancies
Abstract: Carbohydrate N-acetylgalactosamine 4-0 sulfotransferase 9 (CHST9) belongs to the N-acetylgalactosamine 4-sulfotransferase (GalNAc4ST) family. A recent array-based study implicated the presen...
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Xiaosu Zhao,
Qi Wu,
Xinrong Fu,
Bo Yu,
Yong Shao,
Hong Yang,
Ming Guan,
Xiaojun Huang,
Wei Zhang,
Jun Wan
et al.
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176-179
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Numerical chromosomal changes and risk of development of myelodysplastic syndrome–acute myeloid leukemia in patients with Fanconi anemia
Abstract: Fanconi Anemia (FA) is an inherited bone marrow failure syndrome characterized by congenital abnormalities, progressive marrow failure and predisposition to myelodysplastic syndrome (MDS), a...
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Parinda A. Mehta,
Richard E. Harris,
Stella M. Davies,
Mi-Ok Kim,
Robin Mueller,
Beatrice Lampkin,
Jun Mo,
Kasiani Myers,
Teresa A. Smolarek
et al.
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180-186
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Acute myeloid leukemia associated with t(1;3)(p36;q21) and extreme thrombocytosis: a clinical study with literature review
Abstract: We present an unusual case study on acute myeloid leukemia associated with t(1;3) and extreme thrombocytosis, along with a thorough review on relevant literature of t(1;3) cases (58 patients...
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Gayoung Lim,
Min Jin Kim,
Seung Hwan Oh,
Sun Young Cho,
Hee Joo Lee,
Jin-Tae Suh,
Juhie Lee,
Woo-In Lee,
Kyung Sam Cho,
Tae Sung Park
et al.
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187-192
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Cytogenetic features of 5q deletion and 5q− syndrome in myelodysplastic syndrome in Korea; marker chromosomes proved to be chromosome 5 with interstitial deletion by fluorescence in situ hybridization
Abstract: We characterized the cytogenetic changes and prognostic characteristics of 133 Korean patients with myelodysplastic syndrome (MDS), focusing on 5q− syndrome and MDS with chromosome abnormali...
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Hye Ryun Lee,
Bora Oh,
Dae Sik Hong,
Dae Young Zang,
Hwi-Joong Yoon,
Hyeoung Joon Kim,
Inho Kim,
Jae-Sook Ahn,
June-Won Cheong,
Kyung-A Lee,
Kyung Sam Cho,
Mark Hong Lee,
Soo-Mee Bang,
Tae Young Kim,
Yeo-Min Yun,
Yoo Hong Min,
You Kyoung Lee,
Dong Soon Lee,
AML/MDS Working Party of the Korean Society of Hematology
et al.
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193-202
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Human fetal/tumor metakaryotic stem cells: pangenomic homologous pairing and telomeric end-joining of chromatids
Abstract: Metakaryotic cells and syncytia with large, hollow, bell-shaped nuclei demonstrate symmetrical and asymmetrical amitotic nuclear fissions in microanatomical positions and numbers expected of...
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Amanda N. Gruhl,
Elena V. Gostjeva,
William G. Thilly,
Janna N. Fomina,
Firouz Darroudi
et al.
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203-208
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Clonal heterogeneity and chromosomal instability at disease presentation in high hyperdiploid acute lymphoblastic leukemia
Abstract: Although aneuploidy has many possible causes, it often results from underlying chromosomal instability (CIN) leading to an unstable karyotype with cell-to-cell variation and multiple subclon...
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Anna Talamo,
Yves Chalandon,
Alfio Marazzi,
Martine Jotterand
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209-214
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GSTT1 copy number gain is a poor predictive marker for escalated-dose imatinib treatment in chronic myeloid leukemia: genetic predictive marker found using array comparative genomic hybridization
Abstract: In a study population of 45 patients who were previously enrolled in an imatinib dose escalation trial, genome-wide screening for regions of genetic gains and losses was performed using arra...
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Youngil Koh,
Dae-Young Kim,
Sung-Hyo Park,
Seung-Hyun Jung,
Eunkyung Park,
Hyeoung-Joon Kim,
Sang Kyun Sohn,
Young Don Joo,
Seok Jin Kim,
Ho-Jin Shin,
Sung-Hyun Kim,
Hong Suk Song,
Jooseop Chung,
Inho Kim,
Sung-Soo Yoon,
Byoung Kook Kim,
Seung-Hun Shin,
Yeun-Jun Chung,
Seonyang Park
et al.
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215-221
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EGFR expression and gene copy number in triple-negative breast carcinoma
Abstract: Most basal-like breast carcinomas are estrogen receptor negative, progesterone receptor negative, and cerb-B2/HER-2/neu negative—the so-called triple-negative breast carcinomas—with high epi...
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Berrak Gumuskaya,
Murat Alper,
Sema Hucumenoglu,
Kadri Altundag,
Aysegul Uner,
Gulnur Guler
et al.
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222-229
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Germline mutations of BRCA1 and BRCA2 genes in Turkish breast, ovarian, and prostate cancer patients
Abstract: Distribution and prevalence of germline mutations in BRCA1 and BRCA2 differ among different populations. For the Turkish population, several studies have addressed high-risk breast cancer an...
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Esra Manguoğlu,
Şefik Güran,
Deniz Yamaç,
Taner Çolak,
Mehmet Şimşek,
Mehmet Baykara,
Mustafa Akaydın,
Güven Lüleci
et al.
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230-237
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Evaluation of upper urinary tract tumors by FISH in Chinese patients
Abstract: Upper urinary tract tumor (UUTT) usually presents a high grade and stage, and recurs frequently. The aim of this study was to evaluate the utility of a fluorescence in situ hybridization (FI...
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Zhengfei Shan,
Peng Wu,
Shaobin Zheng,
Wanlong Tan,
Haikuan Zhou,
Yi Zuo,
Huan Qi,
Peng Zhang,
Hongmei Peng,
Yanfen Wang
et al.
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238-246
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6p21 rearrangements in uterine leiomyomas targeting HMGA1
Abstract: To quantify the expression of HMGA1 mRNA in uterine leiomyomas, the expression of HMGA1 was analyzed in a series including tumors with aberrations of chromosome 6 (n = 7) and cytogenetically...
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Maliheh Hashemi Nezhad,
Norbert Drieschner,
Sabrina Helms,
Anke Meyer,
Mahboobeh Tadayyon,
Markus Klemke,
Gazanfer Belge,
Sabine Bartnitzke,
Käte Burchardt,
Christiane Frantzen,
Ernst Heinrich Schmidt,
Jörn Bullerdiek
et al.
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247-252
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Urine from current smokers induces centrosome aberrations and spindle defects in vitro in nonmalignant human cell lines
Abstract: Tobacco smoke containing numerous derived chemical carcinogens is the main risk factor for urothelial carcinoma. These carcinogens can induce DNA damage leading to chromosomal instability, w...
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Ute Gabriel,
Michelle Giehl,
Wiltrud Haass,
Lutz Trojan,
Maurice Stephan Michel,
Wolf-Karsten Hofmann,
Wolfgang Seifarth,
Alice Fabarius
et al.
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253-262
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Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of proline related genotype in advanced tumors in an ethnic Kashmiri population
Abstract: Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their eff...
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Arshad A. Pandith,
Zafar A. Shah,
Nighat P. Khan,
Roohi Rasool,
Dil Afroze,
Adfar Yousuf,
Saleem Wani,
Mushtaq Siddiqi
et al.
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263-268
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Correlation between clinical characteristics, survival and genetic alterations in patients with hepatocellular carcinoma from Saudi Arabia
Abstract: Amplification of the two oncogenes ERBB2 and MYC and deletion of the tumor suppressor gene TP53 are frequently encountered in cancerous tissues. The purpose of this study was to use the fluo...
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Ahmed Al-Qahtani,
Tahani Al-Hazzani,
Turki Al-hussain,
Abdulmonem Al-Ghamdi,
Hadeel Al-Mana,
Saud Al-Arifi,
Mohammed Al-Ahdal,
Magdy Aly
et al.
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269-277
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FISH-negative cryptic PML–RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature
Abstract: Although a normal karyotype according to conventional cytogenetic analysis in association with cryptic t(15;17) has been infrequently reported in cases of acute promyelocytic leukemia (APL),...
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Min Jin Kim,
Sun Young Cho,
Myeong-Hee Kim,
Jae Jin Lee,
So Young Kang,
Eun Hae Cho,
Jungwon Huh,
Hwi-Joong Yoon,
Tae Sung Park,
Woo-In Lee,
Rolf Marschalek,
Claus Meyer
et al.
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278-283
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| Short communications |
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B lymphoblastic leukemia with ETV6 amplification
Abstract: We presente a case of acute lymphoblastic leukemia caused by ETV6 amplification. Although the cytogenetic result revealed complex karyotype, multicolor fluorescence in situ hybridization and...
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Hyojin Chae,
Myungshin Kim,
Jihyang Lim,
Yonggoo Kim,
Kyungja Han,
Seok Lee
et al.
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284-287
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Therapy-related acute myeloid leukemia with t(2;11)(q37;q23) after treatment for osteosarcoma
Abstract: The survival rate for children with osteosarcoma (OS) has improved dramatically with the introduction of multiagent chemotherapy. As the number of pediatric cancer survivors increases, there...
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Bella Bielorai,
Claus Meyer,
Luba Trakhtenbrot,
Hana Golan,
Esther Rozner,
Ninette Amariglio,
Shai Izraeli,
Rolf Marschalek,
Amos Toren
et al.
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288-291
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FLT3-internal tandem duplication in a pediatric patient with t(8;21) acute myeloid leukemia
Abstract: Patients diagnosed with t(8;21)-acute myeloid leukemia (AML) are currently considered to have good prognoses, but about half of these patients relapse. FLT3-internal tandem duplication (ITD)...
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Machiko Kawamura,
Hidefumi Kaku,
Tateki Ito,
Nobuaki Funata,
Tomohiko Taki,
Akira Shimada,
Yasuhide Hayashi
et al.
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292-296
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The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases
Abstract: Among patients with acute myeloid leukemia (AML), the t(6;9) (p22;q34) is a rare but defined subset with a poor prognosis. We report 16 patients with the t(6;9), of whom 13 had AML, 2 had my...
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Monika Gupta,
J. Ashok Kumar,
Usha Sitaram,
S. Neeraj,
A. Nancy,
Poonkuzhali Balasubramanian,
Aby Abraham,
Vikram Mathews,
Auro Viswabandya,
Biju George,
Mammen Chandy,
Alok Srivastava,
Vivi M. Srivastava
et al.
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297-302
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Three rearrangements of chromosome 5 in a patient with myelodysplastic syndrome: an atypical deletion 5q, a complex intrachromosomal rearrangement of chromosome 5, and a paracentric inversion of chromosome 5
Abstract: We report the case of a 74-year-old man who sought care for de novo myelodysplastic syndrome (RAEB-1). Conventional cytogenetic techniques showed a karyotype with two different deletions of ...
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Nathalie Douet-Guilbert,
Audrey Basinko,
Jean-Richard Eveillard,
Frédéric Morel,
Marie-Josée Le Bris,
Nadia Guéganic,
Clément Bovo,
Angèle Herry,
Christian Berthou,
Marc De Braekeleer
et al.
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303-308
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Chromosomal alterations in Malaysian patients with nasopharyngeal carcinoma analyzed by comparative genomic hybridization
Abstract: Nasopharyngeal carcinoma (NPC) is one of the most common cancers in Malaysia, mainly occurring among the Chinese population. To detect common genetic alterations in NPC, we screened seven ca...
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M.N. Natasya Naili,
C.H. Hasnita,
A.K. Shamim,
J. Hasnan,
M.I. Fauziah,
M.Y. Narazah,
A. James,
S. Zulkiflee,
M.M.T. Nidzam,
B.A. Zilfalil
et al.
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309-312
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Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma
Abstract: Plexiform (multinodular) cellular schwannomas are rare tumors, not associated with neurofibromatosis type 1, that occur more often in children and can be congenital. Their biology is benign ...
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Elisa Tassano,
Angela Rita Sementa,
Elisa Tavella,
Alberto Garaventa,
Claudio Panarello,
Cristina Morerio
et al.
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313-315
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Screening for common copy-number variants in cancer genes
Abstract: For most cases of colorectal cancer that arise without a family history of the disease, it is proposed that an appreciable heritable component of predisposition is the result of contribution...
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Jess Tyson,
Tamsin M.O. Majerus,
Susan Walker,
John A.L. Armour
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316-323
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Screening for DNA copy number aberrations in mucinous adenocarcinoma arising from the minor salivary gland: two case reports
Abstract: Mucinous adenocarcinoma (MAC) is a rare malignancy in the minor salivary gland. To our knowledge, genomic alterations in this tumor have not been reported previously. To identify DNA copy nu...
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Kenichiro Uchida,
Atsunori Oga,
Takamitsu Mano,
Hitoshi Nagatsuka,
Yoshiya Ueyama,
Kohsuke Sasaki
et al.
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324-327
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Translocation (3;8)(q27;q24) in two cases of triple hit lymphoma
Abstract: Unclassifiable lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma is a new category of B-cell lymphoma appearing in the new World Health Organizat...
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Cristina Motlló,
Javier Grau,
Jordi Juncà,
Neus Ruiz,
José-Luis Mate,
Elisa Orna,
José-Tomás Navarro,
Susana Vives,
Juan-Manuel Sancho,
Daniel Esteban,
Isabel Granada,
Evarist Feliu,
Josep-Maria Ribera,
Fuensanta Millá
et al.
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328-332
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A pericentric inv(9)(p22q34) of the der(9)t(9;22)(q34;q11.2) is a recurrent secondary anomaly in Ph-positive leukemia
Abstract: A pericentric inv(9)(p22q34) of the derivative chromosome 9 that resulted from a standard t(9;22)(q34;q11.2) was identified by R-banding karyotypic analysis and fluorescence in situ hybridiz...
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Jinlan Pan,
Yongquan Xue,
Huiying Qiu,
Suning Chen,
Jun Zhang,
Yafang Wu,
Juan Shen,
Yong Wang
et al.
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333-340
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| Letters to the editor |
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Chromosomal imbalances in urinary bladder paraganglioma
Paragangliomas are derived from paraganglionic tissue located along the paravertebral and paraaortic axis from skull base to pelvic floor . The most frequent primary sites are the organ of Zuckerkandl...
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Inga-Marie Schaefer,
Bastian Gunawan,
László Füzesi,
Manfred Blech,
Josef Frasunek,
Hagen Loertzer
et al.
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341-344
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Myelodysplastic syndrome with isochromosome 5p and trisomy 8 after treatment of a multiple myeloma
Here, we report a case of a 77-year-old Spanish woman diagnosed with multiple myeloma (MM) who developed secondary myelodysplastic syndrome after treatment with melphalan and prednisone. Treatment of ...
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Maria Angeles Jimenez-Sousa,
Maria Teresa Ferro,
Maria Talavera,
Concepcion Villalon,
Pablo Cabello,
Jose Laraña,
Pilar Herrera,
Jose Miguel Garcia Sagredo
et al.
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345-347
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A case of acute myeloid leukemia initially treated as chronic lymphocytic leukemia: what do we know about t(4;12)(q12;p13)?
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with incidence approaching 13,000 cases in the United States in 2008. It is diagnosed based on the percentage of blasts in the...
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Aref Al-Kali,
Mohamad Cherry,
Kristopher Kimmell,
Jennifer Holter,
William Kern,
Bradley Gehrs,
Howard Ozer,
George Selby
et al.
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348-351
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A novel t(10;12)(q21;p13) involving ETV6 in a patient with acute myeloid leukemia
Acute myeloid leukemia (AML) is a worldwide disease with a total incidence of all ages combined of 2.5 cases per 100,000 people per year. It is one of the most common types of leukemia among adults an...
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Anna S. Sowa,
Aurelia M. Meloni-Ehrig,
April Tos,
Jennifer Jahn,
Shalini Dogra,
Victor E. Nava,
JoAnn C. Kelly,
Philip N. Mowrey
et al.
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352-354
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Letter to the Editor regarding the article “Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenic and prognostic implications”
In the article “Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenic and prognostic implications” by Zaccaria et al. on behal...
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Vesna Najfeld
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355-356
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Response to the letter by Najfeld regarding the article “Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenetic and prognostic implications”
I thank Prof. Najfeld for her comments. Her letter allows me to clarify some points. I do not disagree about the multistep process of CML and the possibility that the Philadelphia chromosome (Ph) or o...
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Alfonso Zaccaria
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357
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Response to Zaccaria regarding the article “Chromosome abnormalities additional to the Philadelphia chromosome at the diagnosis of chronic myelogenous leukemia: pathogenetic and prognostic implications”
I am very grateful to Dr. Zaccaria’s clarification. However, the main point remains. To suggest that CML has a biclonal origin, based on cytogenetic evidence alone is a misleading perception since the...
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Vesna Najfeld
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358
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| Frontmatter |
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Table of Contents
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A1-A4
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