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The sterile immune response during hepatic ischemia/reperfusion
21 May 2012
Rowan F. van Golen, Thomas M. van Gulik, Michal Heger
Abstract: Hepatic ischemia and reperfusion elicits an immune response that lacks a microbial constituent yet poses a potentially lethal threat to the host. In this sterile setting, the immune system i...
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Plasticity and cross-talk of Interleukin 6-type cytokines
17 May 2012
Christoph Garbers, Heike M. Hermanns, Fred Schaper, Gerhard Müller-Newen, Joachim Grötzinger, Stefan Rose-John, Jürgen Scheller
Abstract: Interleukin (IL)-6-type cytokines are critically involved in health and disease. The duration and strength of IL-6-type cytokine-mediated signaling is tightly regulated to avoid overshooting...
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SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer
16 May 2012
Yi Li, Colin de Haar, Maikel P. Peppelenbosch, C. Janneke van der Woude
Abstract: Inflammatory bowel disease (IBD) has unclear pathogenesis and it is related to the increasing risk of developing colorectal cancer (CRC). Recent studies have uncovered the molecular mechanis...
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Insensitivity to the growth inhibitory effects of activin A: An acquired capability in prostate cancer progression
14 May 2012
Edward Ottley, Elspeth Gold
Abstract: Prostate cancer (PCa), the most common non-skin cancer in men, is a worldwide health concern. Treatment options for aggressive PCa are limited to androgen deprivation therapies (ADT), which ...
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Interleukin-6, its role in fibrosing conditions
07 May 2012
Steven O’Reilly, Marzena Ciechomska, Rachel Cant, Thomas Hügle, Jacob M. van Laar
Abstract: Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune response. It is secreted by a wide array of cell types, however, its target cells are more restricted...
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