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N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model
23 May 2012
Yasue Ishii-Osai, Toshiharu Yamashita, Yasuaki Tamura, Noriyuki Sato, Akira Ito, Hiroyuki Honda, Kazumasa Wakamatsu, Shosuke Ito, Eiichi Nakayama, Masae Okura, Kowichi Jimbow
Abstract: Background: N-propionyl-4-S-cysteaminylphenol (NPr-4-S-CAP) is selectively incorporated into melanoma cells and degrades them. However, it remains unclear whether NPr-4-S-CAP can induce cell...
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Serum biomarker in neurofibromatosis type 1
21 May 2012
Yuichi Yoshida, Minao Furumura, Makoto Tahira, Takashi Horie, Osamu Yamamoto
Neurofibromatosis type 1 (NF1) (OMIM #162200) is an autosomal dominant disorder characterized by café-au-lait spots and neurofibromas . It has been shown that interaction between NF1−/− Schwann cells ...
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New insights into therapy by mathematical analysis: Recalcitrant granulated improved more than sclerotic venous leg ulcers with amelogenin treatment
21 May 2012
Regina Renner, Jan C. Simon
Abstract: Background: Chronic wounds are both time consuming as well as costly. A new therapeutic option for those wounds might be amelogenin, which supplies a temporary matrix to the fibroblasts and ...
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Identification of anti-melanogenic natural compounds from Galega officinalis and further drug repositioning
21 May 2012
Ji-Seon Lee, Won-Serk Kim, Jin-Ju Kim, Young-Won Chin, Ho-Chang Jeong, Joon-Seok Choi, Hyung-Geun Min, Hyuk-Jin Cha
Seven extracts were selected from in-house natural products library that have reportedly and/or historically showed anti-inflammatory effects and/or anti-tumorigenic properties (). B16F1 cells were tr...
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A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type
17 May 2012
Rieko Kabashima-Kubo, Motonobu Nakamura, Jun-ichi Sakabe, Kazunari Sugita, Ryosuke Hino, Tomoko Mori, Miwa Kobayashi, Toshinori Bito, Kenji Kabashima, Koetsu Ogasawara, Yukiko Nomura, Toshifumi Nomura, Masashi Akiyama, Hiroshi Shimizu, Yoshiki Tokura
Summary: Background: Atopic dermatitis (AD) can be classified into the major extrinsic type with high serum IgE levels and impaired barrier, and the minor intrinsic type with normal IgE levels and uni...
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