Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease

Shimada, Kenei; Kawarabayashi, Takahiko; Tanaka, Atsushi; Fukuda, Daiju; Nakamura, Yasuhiro; Yoshiyama, Minoru; Takeuchi, Kazuhide; Sawaki, Tetsuya; Hosoda, Kazuaki; Yoshikawa, Junichi

doi:10.1016/j.diabres.2004.01.003

Next »Diabetes Research and Clinical Practice
Volume 65, Issue 3 , Pages 227-234, September 2004

Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease

Kenei Shimada
- Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
- Corresponding author. Tel.: +81-6-6645-3801; fax: +81-6-6645-3802.
Takahiko Kawarabayashi
- Department of Cardiology, Baba Memorial Hospital, Sakai, Japan
Atsushi Tanaka
- Department of Cardiology, Baba Memorial Hospital, Sakai, Japan
Daiju Fukuda
- Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
Yasuhiro Nakamura
- Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
Minoru Yoshiyama
- Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
Kazuhide Takeuchi
- Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
Tetsuya Sawaki
- Suntory Research Center, Suntory Ltd., Osaka, Japan
Kazuaki Hosoda
- Suntory Research Center, Suntory Ltd., Osaka, Japan
Junichi Yoshikawa
- Department of Internal Medicine and Cardiology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan

Received in revised form 15 January 2004; accepted 21 January 2004. published online 19 August 2004.

Abstract

Background: Oolong tea has been studied for its effect on cardiovascular disease and obesity. Plasma adiponectin levels are reduced in obesity, in patients with type 2 diabetes mellitus and in coronary artery disease (CAD). Objective: To investigate prospectively, whether intake of Oolong tea influences plasma adiponectin levels, low-density lipoprotein (LDL) particle size, total cholesterol, high-density lipoprotein (HDL) cholesterol, LDL cholesterol, serum triglyceride and plasma glucose levels in patients with CAD. Methods: Twenty two patients in our study consumed Oolong tea (1000ml) or water for 1 month in our randomized cross-over study design. Results: There was a significant difference in plasma adiponectin levels before and after 1 month intake of Oolong tea (6.26±3.26μg/ml versus 6.88±3.28μg/ml, P<0.05), and in plasma level LDL particle size (25.02±0.67nm versus 25.31±0.60nm, P<0.01). The water-consuming control group showed no changes (6.28±3.28μg/ml versus 6.23±3.21μg/ml) in adiponectin levels or LDL particle sizes (25.03±0.70nm versus 25.02±0.72nm). We also observed a significant difference in hemoglobin A1c levels (7.23±4.45% versus 6.99±4.30%, P<0.05) before and after intake of Oolong tea. Conclusion: Oolong tea may have beneficial effects on the progression of atherosclerosis in patients with CAD.