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Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy
03 September 2010
Nehmat Houssami, Petra Macaskill, M. Luke Marinovich, J. Michael Dixon, Les Irwig, Meagan E. Brennan, Lawrence J. Solin
Abstract: Purpose: There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT). We review the evidence on surgical margins in BCT for early-stage invasive br...
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Four and a half LIM protein 2 (FHL2) negatively regulates the transcription of E-cadherin through interaction with Snail1
01 September 2010
Wenjing Zhang, Jide Wang, Bing Zou, Claude Sardet, Jianming Li, Colin S.C. Lam, Lui Ng, Roberta Pang, Ivan F.N. Hung, Victoria P.Y. Tan, Bo Jiang, Benjamin C.Y. Wong
Abstract: E-cadherin is a hallmark of epithelial–mesenchymal transition (EMT), which plays a crucial role in cancer metastasis. We previously demonstrated that four and a half LIM protein 2 (FHL2) inh...
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Expression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) by colorectal cancer cells and adjacent stroma cells – Associations with histopathology and patients outcome
01 September 2010
Søren Astrup Jensen, Ben Vainer, Annette Bartels, Nils Brünner, Jens Benn Sørensen
Abstract: Aim: To elucidate cellular features accountable for colorectal cancers’ (CRC) capability to invade normal tissue and to metastasize, we investigated the level of the collagenase matrix metal...
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Downregulation of miR-21 modulates Ras expression to promote apoptosis and suppress invasion of Laryngeal squamous cell carcinoma
01 September 2010
Jingyuan Ren, Dan Zhu, Ming Liu, Yanan Sun, Linli Tian
Abstract: MiRNAs are small, noncoding RNA molecules that emerge as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been caus...
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Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α
30 August 2010
Antonella Naldini, Irene Filippi, Diego Miglietta, Michele Moschetta, Raffaella Giavazzi, Fabio Carraro
Abstract: The casual relationship between inflammation and tumour progression has been widely accepted and the etiology of breast cancer has been associated with inflammatory processes. Interleukin (I...
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