European Urology
Volume 50, Issue 2 , Pages 317-326 , August 2006

Differential Effects of the Antimuscarinic Agents Darifenacin and Oxybutynin ER on Memory in Older Subjects

  • Gary Kay

      Affiliations

    • Washington Neuropsychological Institute, Washington, DC, USA
    • Corresponding Author InformationCorresponding author. Washington Neuropsychological Institute, 4910 Massachusetts Ave NW #100, Washington, DC 20016, USA. Tel. +1 202 686 7520; Fax: +1 202 686 8802.
    • ,
  • Thomas Crook

      Affiliations

    • Psychologix, Inc, Fort Lauderdale, FL, USA
    • ,
  • Ludmyla Rekeda

      Affiliations

    • Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
    • ,
  • Raul Lima

      Affiliations

    • Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
    • ,
  • Ursula Ebinger

      Affiliations

    • Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
    • ,
  • Miguel Arguinzoniz

      Affiliations

    • Novartis Pharma AG, Basel, Switzerland
    • ,
  • Michael Steel

      Affiliations

    • Novartis Pharma AG, Basel, Switzerland

,Accepted 13 March 2006.

  • Image Result

    Study design. CFT=cognitive function test; ER=extended release.

    Study design. CFT=cognitive function test; ER=extended release.

  • Image Result

    Patient flow through the 3-week study.

    Patient flow through the 3-week study.

  • Image Result

    Effects of darifenacin, oxybutynin ER and placebo on accuracy of delayed recall on the Name–Face Association Test at each time point. ER=extended release; ANCOVA=analysis of covariance.

    Effects of darifenacin, oxybutynin ER and placebo on accuracy of delayed recall on the Name–Face Association Test at each time point. ER=extended release; ANCOVA=analysis of covariance.

  • Image Result

    Effects of darifenacin, oxybutynin ER and placebo on accuracy of delayed recall on the First–Last Name Association Test at each time point. ER=extended release; ANCOVA=analysis of covariance.

    Effects of darifenacin, oxybutynin ER and placebo on accuracy of delayed recall on the First–Last Name Association Test at each time point. ER=extended release; ANCOVA=analysis of covariance.

PII: S0302-2838(06)00358-7

doi: 10.1016/j.eururo.2006.03.057

European Urology
Volume 50, Issue 2 , Pages 317-326 , August 2006

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