Tibial Hemangiopericytoma Diagnosed by Nuclear Medicine Techniques

Oncogenic osteomalacia is a rare metabolic bone disease characterized by hypophosphatemia, renal phosphate wasting, suppressed 1,25-dihydroxyvitamin D production, and osteomalacia. A phosphaturic factor secreted by these tumors is responsible for the symptomatology. The main mechanism underlying this disease condition is an over expression of fibroblast growth factor 23 (FGF-23). Complete excision of these tumors facilitates successful reversal of the problem. We report the case of a patient who was crippled and on extensive investigation revealed an oncogenic osteomalacia with tumor focus in right tibia. The tumor was identified as a mesenchymal tumor, i.e. hemangiopericytoma. Tumor excision alleviated patient symptoms with rapid symptomatic and biochemical improvement.

Key Words:  hemangiopericytoma , oncogenic osteomalacia , red blood cell blood pool scan , Tc-methylene diphosphate bone scan

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