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Journal of the American College of Cardiology
Volume 48, Issue 3, Pages 421-676 (01 August 2006)

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STATE-OF-THE-ART PAPER


Intravascular Ultrasound in the Drug-Eluting Stent Era, 12 July 2006
Gary S. Mintz, Neil J. Weissman
pages 421-429
Abstract | Full Text | Full-Text PDF (712 KB)

VIEWPOINT AND COMMENTARY


Efficacy and Safety in Clinical Trials in Cardiovascular Disease, 12 July 2006
Jay N. Cohn
pages 430-433
Abstract | Full Text | Full-Text PDF (71 KB)


Using Measures of Disease Progression to Determine Therapeutic Effect: A Sirens’ Song, 12 July 2006
Christopher B. Granger, John J.V. McMurray
pages 434-437
Abstract | Full Text | Full-Text PDF (86 KB)

CLINICAL RESEARCH

Coronary Artery Disease


Meta-Analysis of Cardiovascular Outcomes Trials Comparing Intensive Versus Moderate Statin Therapy, 12 July 2006
Christopher P. Cannon, Benjamin A. Steinberg, Sabina A. Murphy, Jessica L. Mega, Eugene Braunwald
pages 438-445
Abstract | Full Text | Full-Text PDF (414 KB)


Relation Between Lipoprotein(a) and Fibrinogen and Serial Intravascular Ultrasound Plaque Progression in Left Main Coronary Arteries, 12 July 2006
Marc Hartmann, Clemens von Birgelen, Gary S. Mintz, Martin G. Stoel, Holger Eggebrecht, Heinrich Wieneke, Martin Fahy, Till Neumann, Job van der Palen, Hans W. Louwerenburg, Patrick M.J. Verhorst, Raimund Erbel
pages 446-452
Abstract | Full Text | Full-Text PDF (142 KB)

Heart Failure


In-Stent Restenosis and Remote Coronary Lesion Progression Are Coupled in Cardiac Transplant Vasculopathy But Not in Native Coronary Artery Disease, 12 July 2006
Michael Jonas, James C. Fang, John C. Wang, Satyendra Giri, Dan Elian, Yedael Har-Zahav, Hung Ly, Philip A. Seifert, Jeffrey J. Popma, Campbell Rogers
pages 453-461
Abstract | Full Text | Full-Text PDF (473 KB)

Heart Failure: Editorial Comment


Cardiac Allograft Vasculopathy in Heart Transplant Patients: Pathologic and Clinical Aspects for Angioplasty/Stenting, 12 July 2006
Jon A. Kobashigawa
pages 462-463
Full Text | Full-Text PDF (56 KB)

Cardiac Resynchronization Therapy


Benefit of Combined Resynchronization and Defibrillator Therapy in Heart Failure Patients With and Without Ventricular Arrhythmias, 12 July 2006
Claudia Ypenburg, Lieselot van Erven, Gabe B. Bleeker, Jeroen J. Bax, Marianne Bootsma, Maurits C. Wijffels, Ernst E. van der Wall, Martin J. Schalij
pages 464-470
Abstract | Full Text | Full-Text PDF (135 KB)

Heart Rhythm Disorders


Cumulative Experience of Azimilide-Associated Torsades de Pointes Ventricular Tachycardia in the 19 Clinical Studies Comprising the Azimilide Database, 12 July 2006
Craig M. Pratt, Hussein R. Al-Khalidi, Jose M. Brum, Michael J. Holroyde, Peter J. Schwartz, Stephen R. Marcello, Martin Borggrefe, Paul Dorian, A. John Camm, Azimilide Trials Investigators
pages 471-477
Abstract | Full Text | Full-Text PDF (986 KB)


Dietary Fish and n-3 Fatty Acid Intake and Cardiac Electrocardiographic Parameters in Humans, 12 July 2006
Dariush Mozaffarian, Ronald J. Prineas, Phyllis K. Stein, David S. Siscovick
pages 478-484
Abstract | Full Text | Full-Text PDF (247 KB)


Validation of the Noncontact Mapping System in the Left Atrium During Permanent Atrial Fibrillation and Sinus Rhythm, 12 July 2006
Mark J. Earley, Dominic J.R. Abrams, Simon C. Sporton, Richard J. Schilling
pages 485-491
Abstract | Full Text | Full-Text PDF (2315 KB)


Substrate Mapping to Detect Abnormal Atrial Endocardium With Slow Conduction in Patients With Atypical Right Atrial Flutter, 12 July 2006
Jin Long Huang, Ching-Tai Tai, Yenn-Jiang Lin, Bien-Hsien Huang, Kun-Tai Lee, Satoshi Higa, Yoga Yuniadi, Yi-Jen Chen, Shih-Lin Chang, Li-Wei Lo, Wanwarang Wongcharoen, Chih-Tai Ting, Shih-Ann Chen
pages 492-498
Abstract | Full Text | Full-Text PDF (2644 KB)

Hypertension


Association of Atrial Natriuretic Peptide and Type A Natriuretic Peptide Receptor Gene Polymorphisms With Left Ventricular Mass in Human Essential Hypertension, 12 July 2006
Speranza Rubattu, Giada Bigatti, Anna Evangelista, Chiara Lanzani, Rosita Stanzione, Laura Zagato, Paolo Manunta, Simona Marchitti, Vanessa Venturelli, Giuseppe Bianchi, Massimo Volpe, Paola Stella
pages 499-505
Abstract | Full Text | Full-Text PDF (116 KB)

Hypertension: Editorial Comment


Natriuretic Peptides and Cardiac Hypertrophy, 12 July 2006
Barry London
pages 506-507
Full Text | Full-Text PDF (63 KB)

Hypertension


Identification of a Cytochrome P450 2C9-Derived Endothelium-Derived Hyperpolarizing Factor in Essential Hypertensive Patients, 12 July 2006
Stefano Taddei, Daniele Versari, Alessandro Cipriano, Lorenzo Ghiadoni, Fabio Galetta, Ferdinando Franzoni, Armando Magagna, Agostino Virdis, Antonio Salvetti
pages 508-515
Abstract | Full Text | Full-Text PDF (221 KB)

Autonomic Function


Norepinephrine Transporter Inhibition Prevents Tilt-Induced Pre-Syncope, 12 July 2006
Christoph Schroeder, Andreas L. Birkenfeld, Antje F. Mayer, Jens Tank, Andre Diedrich, Friedrich C. Luft, Jens Jordan
pages 516-522
Abstract | Full Text | Full-Text PDF (201 KB)


Angiotensin-Converting Enzyme Genotype Predicts Cardiac and Autonomic Responses to Prolonged Exercise, 12 July 2006
Euan A. Ashley, Attila Kardos, Ewan S. Jack, Walter Habenbacher, Mathew Wheeler, Young M. Kim, Jeffrey Froning, Jonathan Myers, Gregory Whyte, Victor Froelicher, Pamela Douglas
pages 523-531
Abstract | Full Text | Full-Text PDF (408 KB)

Ultrasound and Vascular Function


Noninvasive Low-Frequency Ultrasound Energy Causes Vasodilation in Humans, 12 July 2006
Kiyoshi Iida, Huai Luo, Kohsuke Hagisawa, Takashi Akima, Prediman K. Shah, Tasneem Z. Naqvi, Robert J. Siegel
pages 532-537
Abstract | Full Text | Full-Text PDF (227 KB)

Congenital Heart Disease


Device Closure Rates of Simple Atrial Septal Defects Optimized by the STARFlex Device, 12 July 2006
Alan W. Nugent, Amy Britt, Kimberlee Gauvreau, Gary E. Piercey, James E. Lock, Kathy J. Jenkins
pages 538-544
Abstract | Full Text | Full-Text PDF (226 KB)

PRECLINICAL STUDIES


Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor, 12 July 2006
Mohamed Bellahcene, Sebastien Jacquet, Xue B. Cao, Masaya Tanno, Robert S. Haworth, Joanne Layland, Alamgir M. Kabir, Matthias Gaestel, Roger J. Davis, Richard A. Flavell, Ajay M. Shah, Metin Avkiran, Michael S. Marber
pages 545-555
Abstract | Full Text | Full-Text PDF (712 KB)

Editorial Comment


p38 Mitogen-Activated Protein Kinase: A Future Target for Heart Failure Therapy?, 12 July 2006
Risto Kerkela, Thomas Force
pages 556-558
Full Text | Full-Text PDF (78 KB)

PRECLINICAL STUDIES


Cardiac-Directed Expression of Adenylyl Cyclase VI Facilitates Atrioventricular Nodal Conduction, 12 July 2006
Ashwani Sastry, Elizabeth Arnold, Hunaid Gurji, Atsushi Iwasa, Hanh Bui, Alborz Hassankhani, Hemal H. Patel, James R. Feramisco, David M. Roth, N. Chin Lai, H. Kirk Hammond, Sanjiv M. Narayan
pages 559-565
Abstract | Full Text | Full-Text PDF (548 KB)

EXPEDITED REVIEWS


Antianginal Efficacy of Ranolazine When Added to Treatment With Amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) Trial, 16 June 2006
Peter H. Stone, Nikolay A. Gratsiansky, Alexey Blokhin, I-Zu Huang, Lixin Meng, ERICA Investigators
pages 566-575
Abstract | Full Text | Full-Text PDF (313 KB) | Add-Ons

Editorial Comment


Ranolazine: Augmenting the Antianginal Armamentarium, 16 June 2006
John A. Cairns
pages 576-578
Full Text | Full-Text PDF (64 KB)


Transient Midventricular Ballooning Syndrome: A New Variant, 19 June 2006
R. Todd Hurst, J. Wells Askew, Christina S. Reuss, Richard W. Lee, John P. Sweeney, F. David Fortuin, Jae K. Oh, A. Jamil Tajik
pages 579-583
Abstract | Full Text | Full-Text PDF (332 KB) | Add-Ons

ACC NEWS


President’s Page: John C. (Jack) Lewin, MD: From Rural Maui to CEO of the American College of Cardiology
Steven E. Nissen, Pamela S. Douglas
pages 584-585
Full Text | Full-Text PDF (48 KB)

CORRESPONDENCE

Research Correspondence


Impaired Coronary Microvascular Functions in Patients With Behçet Disease, 12 July 2006
Hakan Gullu, Mustafa Caliskan, Dogan Erdogan, Sema Yilmaz, Recep Dursun, Ozgur Ciftci, Eftal Yucel, Haldun Muderrisoglu
pages 586-587
Full Text | Full-Text PDF (65 KB)


The Effect of Exertional Hypertension Evoked by Weight Lifting on Vascular Endothelial Function, 12 July 2006
Jason W. Jurva, Shane A. Phillips, Amjad Q. Syed, Amina Y. Syed, Susan Pitt, Andrea Weaver, David D. Gutterman
pages 588-589
Full Text | Full-Text PDF (81 KB)


Rising Rates of Cardiac Rhythm Management Device Infections in the United States: 1996 through 2003, 12 July 2006
Andrew Voigt, Alaa Shalaby, Samir Saba
pages 590-591
Full Text | Full-Text PDF (146 KB)

Letters to the Editor


Questions in Cardiac Resynchronization Therapy: Metabolic Implications, 12 July 2006
Tim Karhausen, Martin Stockburger, Wolfram Doehner, Stefan D. Anker
pages 591-592
Full Text | Full-Text PDF (64 KB)


Reply, 12 July 2006
Jeroen J. Bax
page 592
Full Text | Full-Text PDF (56 KB)


Allergic Reactions Following Implantation of Drug-Eluting Stents: A Manifestation of Kounis Syndrome?, 12 July 2006
Nicholas G. Kounis, George N. Kounis, Sophia N. Kouni, George D. Soufras, Constantinos Niarchos, Andreas Mazarakis
pages 592-593
Full Text | Full-Text PDF (64 KB)


Reply, 12 July 2006
Jonathan R. Nebeker, Renu Virmani, Charles L. Bennett, Marc D. Feldman
pages 593-594
Full Text | Full-Text PDF (65 KB)


Real-Time Intracardiac Echocardiographic Imaging of the Posterior Left Atrial Wall Contiguous to Anterior Wall of the Esophagus, 12 July 2006
Jian-Fang Ren, Francis E. Marchlinski, David J. Callans
page 594
Full Text | Full-Text PDF (57 KB)


Reply, 12 July 2006
Eric Good, Hakan Oral, Fred Morady
pages 594-595
Full Text | Full-Text PDF (65 KB)


Chronotropic Incompetence in Heart Failure, 12 July 2006
Klaus K. Witte, Andrew L. Clark
page 595
Full Text | Full-Text PDF (55 KB)


Reply, 12 July 2006
Hung-Fat Tse, Chu-Pak Lau
pages 595-596
Full Text | Full-Text PDF (65 KB)


Role of Septal to Posterior Wall Motion Delay in Cardiac Resynchronization Therapy, 12 July 2006
Maria Vittoria Pitzalis, Massimo Iacoviello, Roberta Romito, Giovanni Luzzi, Matteo Anaclerio, Cinzia Forleo
pages 596-597
Full Text | Full-Text PDF (56 KB)

ACC/AHA PRACTICE GUIDELINES


ACC/AHA 2006 Practice Guidelines for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons
Robert O. Bonow, Blase A. Carabello, Kanu Chatterjee, Antonio C. de Leon, David P. Faxon, Michael D. Freed, William H. Gaasch, Bruce Whitney Lytle, Rick A. Nishimura, Patrick T. O’Gara, Robert A. O’Rourke, Catherine M. Otto, Pravin M. Shah, Jack S. Shanewise, Sidney C. Smith, Alice K. Jacobs, Cynthia D. Adams, Jeffrey L. Anderson, Elliott M. Antman, David P. Faxon, Valentin Fuster, Jonathan L. Halperin, Loren F. Hiratzka, Sharon A. Hunt, Bruce W. Lytle, Rick Nishimura, Richard L. Page, Barbara Riegel
pages 598-675
Full Text | Full-Text PDF (1291 KB)


ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons Online Only
Robert O. Bonow, Blase A. Carabello, Kanu Chatterjee, Antonio C. de Leon, David P. Faxon, Michael D. Freed, William H. Gaasch, Bruce Whitney Lytle, Rick A. Nishimura, Patrick T. O’Gara, Robert A. O’Rourke, Catherine M. Otto, Pravin M. Shah, Jack S. Shanewise, Sidney C. Smith, Alice K. Jacobs, Cynthia D. Adams, Jeffrey L. Anderson, Elliott M. Antman, David P. Faxon, Valentin Fuster, Jonathan L. Halperin, Loren F. Hiratzka, Sharon A. Hunt, Bruce W. Lytle, Rick Nishimura, Richard L. Page, Barbara Riegel
pages e1-e148
Full Text | Full-Text PDF (2340 KB)

Frontmatter


Inside This Issue of JACC
pages A39-A40
Full Text | Full-Text PDF (58 KB)

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