Journal of the American Academy of Child Psychiatry
Volume 25, Issue 6 , Pages 854-856, November 1986

Promethazine Treatment of Children with Attention Deficit Disorder with Hyperactivity—Ineffective and Unpleasant

Dr. Zametkin is Senior Staff Psychiatrist, Child Psychiatry Branch, National Institute of Mental Health, Bldg. 10, Room 6N-240, Bethesda, MD 20892, where reprints may be requested. Drs. Reeves and Webster are clinical instructors and Dr. Werry is Professor and Head. Department of Psychiatry and Behavioral Science, School of Medicine, University of Aukland, New Zealand

Received 2 June 1985; received in revised form 18 March 1986; accepted 18 March 1986.

Eight children with Attention Deficit Disorder with Hyperactivity were treated with methylphenidate and promethazine in an open crossover design study. No improvement occurred with promethazine, while behavioral deterioration in four subjects necessitated discontinuation of the drug in two cases.

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 This study was done at the Department of Psychiatry and Behavioral Science, School of Medicine, University of Aukland, and supported by the Medical Research Council of New Zealand, grant 151 to J. S. W.The authors wish to thank Ms Joanne Fitzpatrick, M.Sc., for her help with data analysis.

PII: S0002-7138(09)60207-7

doi:10.1016/S0002-7138(09)60207-7

Journal of the American Academy of Child Psychiatry
Volume 25, Issue 6 , Pages 854-856, November 1986

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