Journal of Atherosclerosis Research
Volume 10, Issue 3 , Pages 319-325, November 1969

Effect of clofibrate and high fat diets on adrenaline-induced lipolysis in isolated rat adipose tissue*

Received 26 May 1969

Summary 

Adipose tissue from rats fed high fat diets were found to exhibit significantly less adrenaline-induced FFA release than those from rats maintained on low fat commercial diet.

Addition of CPIB to the high fat diet reversed this suppression of adrenaline-induced FFA release by isolated adipose tissue. Supplementation of the diet with cholesterol-cholate also reversed the suppressive effect of high dietary fat on adrenaline-induced lipolysis in vitro.

Adrenaline-induced FFA release in adipose tissue seems to depend upon the metabolic status of the tissue as determined by previous nutrition of the animal.

Key words: Adrenaline, Chlorophenoxyisobutyrate (CPIB), Clofibrate, Free fatty acids (FFA), Medium chain triglyceride (MCT)

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* This study was supported by a grant from the Louisiana Heart Association and in part by Grants Nos. HE-08974 and AM10157 from the National Institutes of Health.

PII: S0368-1319(69)80035-9

Journal of Atherosclerosis Research
Volume 10, Issue 3 , Pages 319-325, November 1969

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