Current Issue March 2012 | Vol.14 No. 2
Full Table of ContentsIssue Highlights
- Relevance, Pathogenesis, and Testing Algorithm for Mismatch Repair-Defective Colorectal Carcinomas: A Report of the Association of Molecular Pathology
This Special Article proposes that parallel MSI, MMR protein immunohistochemistry, and BRAF c.1799T. A mutation testing be performed at the time of a new diagnosis of colorectal carcinoma (CRC). Such testing would classify 94% of all new CRCs and guide secondary molecular testing of the remainder.
- Next-Generation Sequencing for Simultaneous Determination of HPV Load, Subtype, and Associated Genomic Copy Number Changes in Tumors
Next-generation sequencing can be applied to archival head and neck squamous cell carcinoma tumors for the simultaneous detection of the HPV genome and subtype and genomic copy number enumeration, providing a multiplicity of clinically significant data in a single test.
- Implications for Powering Biomarker Discovery Studies
This paper highlights the need to assess intratumor heterogeneity prior to biomarker discovery, resulting in a biomarker study that is properly powered, the need for macrodissection correctly assessed, and requirements for event numbers and number of samples per patient accurately determined.
- A Virtual Pyrogram Generator to Resolve Complex Pyrosequencing Results
Pyrosequencing and Sanger sequencing alone may not be enough to provide a definitive interpretation for certain complex mutations. Iterative analysis using Pyromaker, a freely available software program, is an inexpensive and fast method to resolve such cases.
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Uses and Abuses of JAK2 and MPL Mutation Tests in Myeloproliferative Neoplasms: A Paper from the 2010 William Beaumont Hospital Symposium on Molecular Pathology
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