| Special Article |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Relevance, Pathogenesis, and Testing Algorithm for Mismatch Repair–Defective Colorectal Carcinomas: A Report of the Association for Molecular Pathology
18 January 2012
Loss-of-function defects in DNA mismatch repair (MMR), which manifest as high levels of microsatellite instability (MSI), occur in approximately 15% of all colorectal carcinomas (CRCs). This molecular...
|
William K. Funkhouser,
Ira M. Lubin,
Federico A. Monzon,
Barbara A. Zehnbauer,
James P. Evans,
Shuji Ogino,
Jan A. Nowak
et al.
|
91-103
|
|
| Technical Advances |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Next-Generation Sequencing for Simultaneous Determination of Human Papillomavirus Load, Subtype, and Associated Genomic Copy Number Changes in Tumors
11 January 2012
Human papillomavirus (HPV) infection in cases of squamous cell carcinoma of the oropharynx is a powerful predictive and prognostic biomarker. We describe how the use of next-generation sequencing can ...
|
Caroline Conway,
Rebecca Chalkley,
Alec High,
Kenneth Maclennan,
Stefano Berri,
Preetha Chengot,
Melissa Alsop,
Philip Egan,
Joanne Morgan,
Graham R. Taylor,
John Chester,
Mehmet Sen,
Pamela Rabbitts,
Henry M. Wood
et al.
|
104-111
|
|
|
|
Detection of Hypermethylated Vimentin in Urine of Patients with Colorectal Cancer
16 January 2012
We demonstrated previously that urine contains low-molecular-weight (LMW) (<300 bp), circulation-derived DNA that can be used to detect cancer-specific mutations if a tumor is present. The goal of ...
|
Benjamin P. Song,
Surbhi Jain,
Selena Y. Lin,
Quan Chen,
Timothy M. Block,
Wei Song,
Dean E. Brenner,
Ying-Hsiu Su
et al.
|
112-119
|
|
|
|
A Sample Extraction Method for Faster, More Sensitive PCR-Based Detection of Pathogens in Blood Culture
13 January 2012
Three mechanistically different sample extraction methodologies, namely, silica spin columns, phenol-chloroform, and an automated magnetic capture of polymer-complexed DNA (via an Automate Express ins...
|
John F. Regan,
Manohar R. Furtado,
Maxim G. Brevnov,
Jeanne A. Jordan
|
120-129
|
|
| Regular Articles |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Implications for Powering Biomarker Discovery Studies
16 January 2012
This study examined variations in gene expression between FFPE blocks within tumors of individual patients. Microarray data were used to measure tumor heterogeneity within and between patients and dis...
|
Sian M. Dibben,
Robert J. Holt,
Timothy S. Davison,
Claire L. Wilson,
Janet Taylor,
Ian Paul,
Kieran McManus,
Paul J. Kelly,
Vitali Proutski,
D. Paul Harkin,
Peter Kerr,
Dean A. Fennell,
Jacqueline A. James,
Richard D. Kennedy
et al.
|
130-139
|
|
|
|
Impact of Collection and Storage of Lung Tumor Tissue on Whole Genome Expression Profiling
11 January 2012
Gene expression profiling could assist in revealing biomarkers of lung cancer prognosis and progression. The handling of biological samples may strongly influence global gene expression, a fact that h...
|
Maxim B. Freidin,
Neesa Bhudia,
Eric Lim,
Andrew G. Nicholson,
William O. Cookson,
Miriam F. Moffatt
et al.
|
140-148
|
|
|
|
A Virtual Pyrogram Generator to Resolve Complex Pyrosequencing Results
10 February 2012
We report a freely available software program, Pyromaker, which generates simulated traces for pyrosequencing results based on user inputs. Simulated pyrograms can aid in the analysis of complex pyros...
|
Guoli Chen,
Matthew Theodore Olson,
Alan O'Neill,
Alexis Norris,
Katie Beierl,
Shuko Harada,
Marija Debeljak,
Keila Rivera-Roman,
Samantha Finley,
Amanda Stafford,
Christopher David Gocke,
Ming-Tseh Lin,
James Richard Eshleman
et al.
|
149-159
|
|
|
|
Absolute and Relative Quantification of Placenta-Specific MicroRNAs in Maternal Circulation with Placental Insufficiency–Related Complications
16 January 2012
Placental insufficiency–related complications are one of the leading causes of maternal and perinatal morbidity and mortality. This study investigated the quantification of placenta-specific microRNAs...
|
Ilona Hromadnikova,
Katerina Kotlabova,
Jindrich Doucha,
Klara Dlouha,
Ladislav Krofta
et al.
|
160-167
|
|
|
|
Stability of PCR Targets for Monitoring Minimal Residual Disease in Neuroblastoma
16 January 2012
In neuroblastoma (NB) patients, minimal residual disease (MRD) can be detected by real-time quantitative PCR (qPCR) using NB-specific target genes, such as PHOX2B and TH. However, it is unknown whethe...
|
Janine Stutterheim,
Lily Zappeij-Kannegieter,
Ingrid Øra,
Peter G. van Sluis,
Johannes Bras,
Emmy den Ouden,
Rogier Versteeg,
Huib N. Caron,
C. Ellen van der Schoot,
Godelieve A.M. Tytgat
et al.
|
168-175
|
|
|
|
Combined Molecular Gram Typing and High-Resolution Melting Analysis for Rapid Identification of a Syndromic Panel of Bacteria Responsible for Sepsis-Associated Bloodstream Infection
24 January 2012
Effective diagnosis and treatment of bloodstream infections are often hampered by a lack of time-critical information from blood cultures. Molecular techniques aimed at the detection of circulating pa...
|
Hani Ozbak,
Paul Dark,
Satyanarayana Maddi,
Paul Chadwick,
Geoffrey Warhurst
et al.
|
176-184
|
|
| Reviewer Acknowledgment |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Reviewer Acknowledgment
The Editors gratefully acknowledge the generous assistance of the following reviewers who served The Journal of Molecular Diagnostics between January 1 and December 31, 2011.
|
|
185-186
|
|
| Frontmatter |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Editorial Board
|
|
A1-A2
|
|
|
|
Table of Contents
|
|
A5
|
|
|
|
Instructions to Authors
|
|
A13-A15
|
|
|
|
Scientific Integrity Policy
|
|
A16-A17
|
|
