Journal of Epilepsy
Volume 11, Issue 6 , Pages 335-340, November 1998

Noninvasive cerebral blood volume measurement during seizures using multichannel near infrared spectroscopic topography

  • Eiju Watanabe

      Affiliations

    • From the Department of Neurosurgery, Tokyo Metropolitan Police Hospital, Tokyo, Japan
    • Corresponding Author InformationAddress correspondence and reprint requests to Dr. Eiju Watanabe, Tokyo Metropolitan Police Hospital, Department of Neurosurgery, 2-10-41 Fujimi, Chiyoda-ku, Tokyo 102, Japan.
    • ,
  • Atsushi Maki

      Affiliations

    • From the Hitachi Central Research Laboratory, Tokyo, Japan
    • ,
  • Fumio Kawaguchi

      Affiliations

    • From the Hitachi Medical Corporation, Tokyo, Japan
    • ,
  • Yuichi Yamashita

      Affiliations

    • From the Hitachi Central Research Laboratory, Tokyo, Japan
    • ,
  • Hideaki Koizumi

      Affiliations

    • From the Hitachi Central Research Laboratory, Tokyo, Japan
    • ,
  • Yoshiaki Mayanagi

      Affiliations

    • From the Department of Neurosurgery, Tokyo Metropolitan Police Hospital, Tokyo, Japan

Received 28 April 1998; accepted 31 July 1998.

Near infrared spectroscopic topography (NIRS) is widely recognized as a noninvasive method to measure the regional cerebral blood volume (rCBV) dynamics coupled with neuronal activities. We analyzed the rCBV change in the early phase of epileptic seizures in 12 consecutive patients with medically intractable epilepsy. Seizure was induced by bemegride injection. We used eight-channel NIRS in nine cases and 24-channel in three cases. In all of the cases, rCBV increased rapidly after the seizure onset on the focus side. The increased rCBV was observed for approximately 30–60 seconds. The NIRS method can be applied to monitor the rCBV change continuously during seizures. Therefore, this method may be combined with ictal single photon emission computed tomography (SPECT) as one of the most reliable noninvasive methods of focus diagnosis.

Key words: Near infrared spectroscopy, Functional mapping, epilepsy, Human, hemoglobin, Cerebral blood volume

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PII: S0896-6974(98)00037-1

doi:10.1016/S0896-6974(98)00037-1

Journal of Epilepsy
Volume 11, Issue 6 , Pages 335-340, November 1998

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