Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo

Shannon, Kerry L.; Branca, Rosa T.; Galiana, Gigi; Cenzano, Silvia; Bouchard, Louis-Serge; Soboyejo, Winston; Warren, Warren S.

doi:10.1016/j.mri.2004.10.019

« Previous Next »Magnetic Resonance Imaging
Volume 22, Issue 10 , Pages 1407-1412, December 2004

Simultaneous acquisition of multiple orders of intermolecular multiple-quantum coherence images in vivo

Kerry L. Shannon
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
Rosa T. Branca
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
- Department of Physics, “La Sapienza” University, Rome, Italy
Gigi Galiana
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
Silvia Cenzano
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
Louis-Serge Bouchard
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
Winston Soboyejo
- Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA
Warren S. Warren
- Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
- Corresponding author. Tel.: +1 609 258 3910; fax: +1 609 258 6747.

Received 29 October 2004; accepted 29 October 2004.

Abstract

Until recently, NMR imaging with intermolecular multiple-quantum coherences (iMQCs) has been based on the acquisition of a single echo. In vivo studies of iMQC image contrast would greatly benefit from a method that could acquire several orders of quantum coherence during the same acquisition. This would enable comparison of the image contrast for various orders and eliminate image coregistration problems between scans. It has previously been demonstrated that multiple orders of iMQC images can be simultaneously acquired of a simple phantom. Here, we examine the technique and its effect on biological tissue, both in vivo and in vitro. First, we establish the effectiveness of the iMQC sequence in vivo using earthworms as specimens. We then further show that the multi-CRAZED sequence enhances detection of next generation (nanoparticle) contrast agents on excised tumor tissue.

Keywords: NMR, Multi-CRAZED, Quantum coherence