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Editorial Board
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IFC
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| Meeting Report |
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Author(s) |
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Meeting report: The Schizophrenia International Research Society (SIRS) South America Conference (August 5–7, 2011)
29 March 2012
Abstract: On August 5–7, 2011, São Paulo was home to the first regional meeting of the Schizophrenia International Research Society (SIRS). Over 400 people from many countries attended the activities ...
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Raffael Massuda,
Cristiano Chaves,
Clarissa Trzesniak,
Joao P. Machado-de-Sousa,
Marcus V. Zanetti,
Robin M. Murray,
Wagner F. Gattaz,
Geraldo F. Busatto
et al.
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1-6
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| Genetics |
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Author(s) |
Pages |
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Genetic and functional analysis of the gene encoding neurogranin in schizophrenia
06 February 2012
Abstract: Objectives: Schizophrenia is a highly heritable disorder, but many aspects of its etiology and pathophysiology remain poorly understood. Recently, a SNP rs12807809 located upstream of the ne...
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Yu-Chih Shen,
Ho-Min Tsai,
Min-Chih Cheng,
Shih-Hsin Hsu,
Shih-Fen Chen,
Chia-Hsiang Chen
et al.
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7-13
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Genetic and functional analyses of the gene encoding synaptophysin in schizophrenia
20 February 2012
Abstract: Objectives: Synaptophysin (SYP) has been shown to be critical for regulating neurotransmitter release and synaptic plasticity, a process thought to be disrupted in schizophrenia. In addition...
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Yu-Chih Shen,
Ho-Min Tsai,
Jhen-Wei Ruan,
Yi-Chu Liao,
Shih-Fen Chen,
Chia-Hsiang Chen
et al.
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14-19
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Cortical gyrification in velo-cardio-facial (22q11.2 deletion) syndrome: A longitudinal study
24 February 2012
Abstract: Introduction: Velo-cardio-facial syndrome (VCFS) has been identified as an important risk factor for psychoses, with up to 32% of individuals with VCFS developing a psychotic illness. Indivi...
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Arun Kunwar,
Seethalakshmi Ramanathan,
Joshua Nelson,
Kevin M. Antshel,
Wanda Fremont,
Anne Marie Higgins,
Robert J. Shprintzen,
Wendy R. Kates
et al.
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20-25
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Association between schizophrenia and genetic variation in DCC: A case–control study
14 March 2012
Abstract: Schizophrenia is a highly heritable neurodevelopmental disorder associated with alterations in synaptic connectivity. Deleted in colorectal cancer (DCC), a receptor for the guidance cue netr...
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Alanna Grant,
Ferid Fathalli,
Guy Rouleau,
Ridha Joober,
Cecilia Flores
et al.
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26-31
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Behavioral effects of non-viral mediated RNA interference of synapsin II in the medial prefrontal cortex of the rat
20 February 2012
Abstract: Synapsin II is a synaptic vesicle-associated phosphoprotein that has been implicated in the pathophysiology of schizophrenia. Researchers have demonstrated reductions in synapsin II mRNA and...
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Bailey A. Dyck,
Mattea L. Tan,
Ritesh P. Daya,
Dipannita Basu,
Christal D.R. Sookram,
Nancy Thomas,
Ram K. Mishra
et al.
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32-38
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| Cannabis effects |
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Cannabis use and anticipatory pleasure as reported by subjects with early psychosis and community controls
21 March 2012
Abstract: Background: There is evidence of decreased pleasure and deficits in the anticipation of reward in both psychotic illness and drug addiction. Individuals with low anticipatory pleasure may pr...
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Clifford M. Cassidy,
Martin Lepage,
Philippe-Olivier Harvey,
Ashok Malla
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39-44
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Early cannabis use and Schizotypal Personality Disorder Symptoms from adolescence to middle adulthood
10 February 2012
Abstract: Background: While increasing evidence suggests that cannabis use may play a role in the development of schizophrenia in some young people, less is known about the strength and specificity of...
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Deidre M. Anglin,
Cheryl M. Corcoran,
Alan S. Brown,
Henian Chen,
Quenesha Lighty,
Judith S. Brook,
Patricia R. Cohen
et al.
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45-49
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Effect of cannabis use on the course of schizophrenia in male patients: A prospective cohort study
10 February 2012
Abstract: Background: Findings on the impact of cannabis use on the course of schizophrenia are inconsistent and not conclusive. Aims: To study the effect of cannabis use on the course of schizophreni...
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Daniel van Dijk,
Maarten W.J. Koeter,
Ron Hijman,
René S. Kahn,
Wim van den Brink
et al.
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50-57
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| Glutathione and oxidative stress |
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Decreased glutathione levels predict loss of brain volume in children and adolescents with first-episode psychosis in a two-year longitudinal study
27 February 2012
Abstract: Progressive loss of cortical gray matter (GM), as measured by magnetic resonance imaging, has been described early in the course of first-episode psychosis. This study aims to assess the rel...
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David Fraguas,
Ana Gonzalez-Pinto,
Juan Antonio Micó,
Santiago Reig,
Mara Parellada,
Mónica Martínez-Cengotitabengoa,
Josefina Castro-Fornieles,
Marta Rapado-Castro,
Immaculada Baeza,
Joost Janssen,
Manuel Desco,
Juan Carlos Leza,
Celso Arango
et al.
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58-65
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Cognitive impairment is related to oxidative stress and chemokine levels in first psychotic episodes
26 March 2012
Abstract: Introduction: This study measures the levels of various markers of oxidative stress and inflammation in blood samples from first-episode psychosis (FEP) patients, and examines the associatio...
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Mónica Martínez-Cengotitabengoa,
Karina Soledad Mac-Dowell,
Juan Carlos Leza,
Juan Antonio Micó,
Miryam Fernandez,
Enrique Echevarría,
Julio Sanjuan,
Julián Elorza,
Ana González-Pinto
et al.
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66-72
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| Clinical prodrome, early illness and the first episode |
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Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
21 February 2012
Abstract: Patients with psychosis have higher rates of childhood trauma, which is also associated with adverse effects on cognitive functions such as attention, concentration and mental speed, languag...
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Monica Aas,
Serena Navari,
Ayana Gibbs,
Valeria Mondelli,
Helen L. Fisher,
Craig Morgan,
Kevin Morgan,
James MacCabe,
Abraham Reichenberg,
Jolanta Zanelli,
Paul Fearon,
Peter B. Jones,
Robin M. Murray,
Carmine M. Pariante,
Paola Dazzan
et al.
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73-79
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Diffusion tensor imaging tractography of the fornix and belief confidence in first-episode psychosis
15 March 2012
Abstract: Previous studies have demonstrated that patients with psychosis are more confident in beliefs and judgments compared to healthy participants and psychiatric controls with major depression. A...
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Lisa Buchy,
David Luck,
Yvonne Czechowska,
Ashok Malla,
Ridha Joober,
Martin Lepage
et al.
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80-84
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MTR abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls
29 February 2012
Abstract: Background: Neuroimaging studies have suggested gray (GM) and white matter (WM) abnormalities in early stages of schizophrenia. We aimed at evaluating subtle parenchymal alterations in indiv...
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Georg Bohner,
Denny Milakara,
Henning Witthaus,
Jürgen Gallinat,
Michael Scheel,
Georg Juckel,
Randolf Klingebiel
et al.
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85-90
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Language processing abnormalities in adolescents with psychotic-like experiences: An event related potential study
14 February 2012
Abstract: Language impairments are a well established finding in patients with schizophrenia and in individuals at-risk for psychosis. A growing body of research has revealed shared risk factors betwe...
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Jennifer Murphy,
Mathieu M. Blanchard,
Caroline Rawdon,
Fergal Kavanagh,
Ian Kelleher,
Mary C. Clarke,
Richard A.P. Roche,
Mary Cannon
et al.
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91-96
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Electroconvulsive therapy improves antipsychotic and somnographic responses in adolescents with first-episode psychosis — A case–control study
20 February 2012
Abstract: Objective: Previous studies have demonstrated the effectiveness of electroconvulsive therapy (ECT) in pharmacotherapy-resistant neuropsychiatric conditions. This study aimed to evaluate the ...
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Zhang-Jin Zhang,
Yun-Chun Chen,
Hua-Ning Wang,
Huai-Hai Wang,
Yun-Yun Xue,
Shu-Fang Feng,
Qing-Rong Tan
et al.
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97-103
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Is deterioration of IQ a feature of first episode psychosis and how can we measure it?
20 February 2012
Abstract: Estimates of pre-morbid IQ are widely used to measure the trajectory of cognitive function and decline in people with schizophrenia. This study examined the usefulness of two indices of decl...
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Jennifer A. O'Connor,
Benjamin D.R. Wiffen,
Abraham Reichenberg,
Monica Aas,
M. Aurora Falcone,
Manuela Russo,
Poonam Gardner Sood,
Heather Taylor,
Anthony S. David
et al.
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104-109
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Cognitive changes following antidepressant or antipsychotic treatment in adolescents at clinical risk for psychosis
29 February 2012
Abstract: Background: Improving neurocognitive abilities is a treatment priority in schizophrenia, however, pharmacological efforts to enhance deficits after illness onset have resulted in quite modes...
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Christopher R. Bowie,
Danielle McLaughlin,
Ricardo E. Carrión,
Andrea M. Auther,
Barbara A. Cornblatt
et al.
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110-117
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Longitudinal changes in semantic categorization performance after symptomatic remission from first-episode psychosis: A 3-year follow-up study
27 March 2012
Abstract: Semantic categorization abnormalities have been observed in schizophrenia, but studies have rarely focused on the longitudinal trajectory. In this study, we consider semantic performance and...
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Christy Lai-Ming Hui,
Julia Longenecker,
Gloria Hoi-Yan Wong,
Jennifer Yee-Man Tang,
Wing-Chung Chang,
Sherry Kit-Wah Chan,
Edwin Ho-Ming Lee,
Eva Lai-Wah Dunn,
May Yin-King Miao,
Wai-Song Yeung,
Chi-Keung Wong,
Wah-Fat Chan,
Wai-Nang Tang,
Eric Yu-Hai Chen
et al.
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118-123
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Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia
19 March 2012
Abstract: Recent studies have suggested an important role for Broca's region and its right hemisphere counterpart in the pathophysiology of schizophrenia, owing to its roles in language and interperso...
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Norichika Iwashiro,
Motomu Suga,
Yosuke Takano,
Hideyuki Inoue,
Tatsunobu Natsubori,
Yoshihiro Satomura,
Shinsuke Koike,
Noriaki Yahata,
Mizuho Murakami,
Masaki Katsura,
Wataru Gonoi,
Hiroki Sasaki,
Hidemasa Takao,
Osamu Abe,
Kiyoto Kasai,
Hidenori Yamasue
et al.
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124-131
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Self-determination and first-episode psychosis: Associations with symptomatology, social and vocational functioning, and quality of life
26 March 2012
Abstract: Self-determination theory (SDT) postulates that satisfaction of three basic psychological needs (i.e., autonomy, competence, and well-being) promotes motivation, well-being, and growth acros...
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Nicholas J.K. Breitborde,
Petra Kleinlein,
Vinod H. Srihari
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132-136
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| More data from the CATIE trial |
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Author(s) |
Pages |
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Impact of the CATIE trial on antipsychotic prescribing patterns at a state psychiatric facility
27 February 2012
Abstract: Introduction: Results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) indicate that, with the exception of olanzapine, no substantial overall differences were id...
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Angela M. Koranek,
Tawny L. Smith,
Lisa M. Mican,
Karen L. Rascati
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137-140
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Treatment response trajectories and antipsychotic medications: Examination of up to 18 months of treatment in the CATIE chronic schizophrenia trial
10 February 2012
Abstract: Background: Trajectory studies highlight heterogeneity in treatment response, although they are yet to systematically differentiate between antipsychotic medications. Aims: To compare treatm...
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Stephen Z. Levine,
Jonathan Rabinowitz,
Douglas Faries,
Anthony H. Lawson,
Haya Ascher-Svanum
et al.
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141-146
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Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: Analysis of CATIE data
10 February 2012
Abstract: Increased attention has been given to treatment of negative symptoms and its potential impact on functional outcomes, however previous inferences have been confounded by the fact that measur...
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Jonathan Rabinowitz,
Stephen Z. Levine,
George Garibaldi,
Dragana Bugarski-Kirola,
Carmen Galani Berardo,
Shitij Kapur
et al.
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147-150
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| Risk factors for development of schizophrenia |
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Medical and developmental risk factors of catatonia in children and adolescents: A prospective case–control study
09 March 2012
Abstract: Context: Rare diseases have been associated with more and more genetic and non genetic causes and risk factors. But this has not been systematically assessed in catatonia, one of the psychia...
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Angèle Consoli,
Marie Raffin,
Claudine Laurent,
Nicolas Bodeau,
Dominique Campion,
Zahir Amoura,
Frederic Sedel,
Isabelle An-Gourfinkel,
Olivier Bonnot,
David Cohen
et al.
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151-158
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Low maternal retinol as a risk factor for schizophrenia in adult offspring
01 March 2012
Abstract: Background: Prenatal micronutrient deficiency has been linked to later development of schizophrenia among offspring; however, no study has specifically investigated the association between v...
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YuanYuan Bao,
Ghionul Ibram,
William S. Blaner,
Charles P. Quesenberry,
Ling Shen,
Ian W. McKeague,
Catherine A. Schaefer,
Ezra S. Susser,
Alan S. Brown
et al.
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159-165
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Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition
02 March 2012
Abstract: There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in ...
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Janice A. Husted,
Rashid Ahmed,
Eva W.C. Chow,
Linda M. Brzustowicz,
Anne S. Bassett
et al.
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166-168
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| Auditory hallucinations |
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Structural correlates of auditory hallucinations in schizophrenia: A meta-analysis
20 February 2012
Abstract: Background: Despite being one of the most common symptoms of schizophrenia, determining the neural correlates of auditory hallucinations still remains elusive with various studies providing ...
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Lena Palaniyappan,
Vijender Balain,
Joaquim Radua,
Peter F. Liddle
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169-173
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The effect of rTMS on auditory hallucinations: Clues from an EEG-rTMS study
30 January 2012
Abstract: Objective: Repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal region has been proposed as a therapeutic option for auditory verbal hallucinations (AVH). However, most...
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Remko van Lutterveld,
Sanne Koops,
Dennis J.L.G. Schutter,
Ellen Geertsema,
Cornelis J. Stam,
René S. Kahn,
Iris E.C. Sommer
et al.
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174-179
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| General functioning |
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Niacin subsensitivity is associated with functional impairment in schizophrenia
26 March 2012
Abstract: Objective: Sensitivity to the skin flush effect of niacin is reduced in a portion of patients with schizophrenia. Though this peripheral physiological abnormality has been widely replicated,...
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Erik Messamore
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180-184
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Self-esteem as a mediator of the relationship between role functioning and symptoms for individuals with severe mental illness: A prospective analysis of Modified Labeling theory
29 February 2012
Abstract: Background: Despite a growing body of evidence supporting the efficacy of psychosocial rehabilitation for individuals with severe mental illness (SMI), a large proportion of these individual...
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Lisa Davis,
Seth Kurzban,
John Brekke
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185-189
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Predictors of the accuracy of self assessment of everyday functioning in people with schizophrenia
05 March 2012
Abstract: Despite multiple lines of evidence suggesting that people with schizophrenia have substantial problems in self-reporting everyday functioning and cognitive performance, self-report methods a...
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Samir Sabbag,
Elizabeth W. Twamley,
Lea Vella,
Robert K. Heaton,
Thomas L. Patterson,
Philip D. Harvey
et al.
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190-195
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Self-reported empathy deficits are uniquely associated with poor functioning in schizophrenia
10 February 2012
Abstract: Background: Social cognitive deficits have been proposed to be among the causes of poor functional outcome in schizophrenia. Empathy, or sharing and understanding the unique emotions and exp...
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Matthew J. Smith,
William P. Horan,
Tatiana M. Karpouzian,
Samantha V. Abram,
Derin J. Cobia,
John G. Csernansky
et al.
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196-202
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A meta-analysis of emotion perception and functional outcomes in schizophrenia
17 February 2012
Abstract: Introduction: Emotion perception (EP) is impaired in schizophrenia, is stable across clinical state, resistant to antipsychotic treatment and linked to symptom severity. Given its pervasive ...
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Farzin Irani,
Sarah Seligman,
Vidyulata Kamath,
Christian Kohler,
Ruben C. Gur
et al.
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203-211
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| Social cognition/Theory of mind |
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Social cognition and quality of life in schizophrenia
09 March 2012
Abstract: Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated...
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Arija Maat,
Anne-Kathrin Fett,
Eske Derks,
GROUP Investigators
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212-218
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Dissociation and social cognition in schizophrenia spectrum disorder
01 March 2012
Abstract: While there is emerging evidence that dissociation is linked with trauma history and possibly symptoms in schizophrenia, it remains unclear whether dissociation represents a symptom dimensio...
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Selwyn B. Renard,
Marieke Pijnenborg,
Paul H. Lysaker
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219-223
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Theory of mind in patients with schizophrenia: Is mentalizing delayed?
09 March 2012
Abstract: Objective: Functional imaging studies have used numerous neurocognitive designs to investigate brain activation during theory of mind (ToM) tasks in patients with schizophrenia. The majority...
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Anya Pedersen,
Katja Koelkebeck,
Matthias Brandt,
Melissa Wee,
Kerstin Annika Kueppers,
Harald Kugel,
Waldemar Kohl,
Jochen Bauer,
Patricia Ohrmann
et al.
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224-229
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| Miscellaneous |
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Comparing three screening tools for drug-induced parkinsonism in patients with advanced schizophrenia: A pilot study
10 February 2012
Abstract: Background: Drug-induced parkinsonism (DIP) is seen in one third of patients exposed to antipsychotic drugs and may lead to complications related to dysphagia and falls. Aside from skilled n...
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Pierre J. Blanchet,
Louise Normandeau,
Pierre H. Rompré
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230-233
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More than just tapping: Index finger-tapping measures procedural learning in schizophrenia
20 February 2012
Abstract: Background: Finger-tapping has been widely studied using behavioral and neuroimaging paradigms. Evidence supports the use of finger-tapping as an endophenotype in schizophrenia, but its rela...
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Felipe N. Da Silva,
Farzin Irani,
Jan Richard,
Colleen M. Brensinger,
Warren B. Bilker,
Raquel E. Gur,
Ruben C. Gur
et al.
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234-240
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Water and metabolite transverse T2 relaxation time abnormalities in the white matter in schizophrenia
22 February 2012
Abstract: Multiple lines of evidence suggest that microstructural abnormalities in the white matter are important in the pathophysiology of schizophrenia. Diffusion MRI approaches which can provide ev...
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Fei Du,
Alissa Cooper,
Bruce M. Cohen,
Perry F. Renshaw,
Dost Öngür
et al.
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241-245
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Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia
23 February 2012
Abstract: Although the developers of the Positive and Negative Syndrome Scale (PANSS) grouped items into three subscales, factor analyses indicate that a five-factor model better characterizes PANSS d...
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R.S. Wallwork,
R. Fortgang,
R. Hashimoto,
D.R. Weinberger,
D. Dickinson
et al.
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246-250
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Reduced arterial compliance in patients with psychiatric diagnoses
29 February 2012
Abstract: Background: Peripheral arterial compliance is a measure of elasticity of the arteries that has been found to be a robust predictor of prevalent arteriosclerosis as well as incident stroke an...
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Maju Mathew Koola,
W. Virgil Brown,
Clifford Qualls,
Bruce Cuthbert,
Jeffrey P. Hollis,
Deanna L. Kelly,
Ngoc-Anh Le,
Jeffrey Raines,
Erica J. Duncan
et al.
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251-253
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| Letters to the Editor |
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The Beck Cognitive Insight Scale: Psychometric properties in a Canadian community sample
26 March 2012
The Beck Cognitive Insight Scale (BCIS) () was developed to evaluate how individuals with psychosis understand their own reasoning processes, beliefs and judgments. In the original BCIS study, establ...
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Lisa Buchy,
Mathieu B. Brodeur,
Martin Lepage
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254-255
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The association between childhood rickets and nonaffective psychosis: A Danish record-linkage study
23 March 2012
It has been proposed that low pre- and/or perinatal vitamin D status may increase the risk of later schizophrenia (). This hypothesis was originally based on various clues from schizophrenia epidemiol...
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John Joseph McGrath,
Signe Sparre Beck-Nielsen,
Elizabeth Cantor-Graae,
Preben Bo Mortensen,
Carsten Bøcker Pedersen
et al.
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256-257
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Corpus callosum volumes in recent-onset schizophrenia are correlated to positive symptom severity after 1year of follow-up
16 March 2012
Predicting the prognosis of schizophrenia is of critical importance but there are no valid biomarkers for such purpose. In case–control studies of schizophrenia using magnetic resonance imaging (MRI),...
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Mauricio H. Serpa,
Maristela S. Schaufelberger,
Pedro G. Rosa,
Fábio L.S. Duran,
Luciana C. Santos,
Robin M. Muray,
Márcia Scazufca,
Paulo R. Menezes,
Geraldo F. Busatto
et al.
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258-259
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Metacognitive functioning and social cognition as predictors of accuracy of self-appraisals of vocational function in schizophrenia
23 March 2012
It has been increasingly recognized that many with schizophrenia spectrum disorders experience impairments in social cognition, which involves processes such as appraising the affects and intentions o...
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Brandi L. Luedtke,
Marina Kukla,
Selwyn Renard,
Giancarlo Dimaggio,
Kelly D. Buck,
Paul H. Lysaker
et al.
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260-261
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Pro12Ala polymorphism of the PPAR-γ2 gene, metabolic syndrome and response to metformin in clozapine-treated patients
29 February 2012
The peroxisome proliferator-activated receptor gamma (PPAR-γ, PPARG or glitazone receptor) encoded by the PPAR-γ gene is implicated in obesity, diabetes, atherosclerosis and cancer ().
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Erika Fernández,
Edgardo Carrizo,
Lisette Connell,
Trino Baptista
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262-263
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A two-stage case–control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population
20 February 2012
Serotonin has been shown to be involved in neurobiological mechanisms underlying schizophrenia (). The gene encoding tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in brain serotonin synthe...
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Yuichiro Watanabe,
Jun Egawa,
Yoshimi Iijima,
Ayako Nunokawa,
Naoshi Kaneko,
Masako Shibuya,
Tadao Arinami,
Hiroshi Ujike,
Toshiya Inada,
Nakao Iwata,
Mamoru Tochigi,
Hiroshi Kunugi,
Masanari Itokawa,
Norio Ozaki,
Ryota Hashimoto,
Toshiyuki Someya
et al.
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264-266
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Abnormal anterior cingulate cortex activity predicts functional disability in schizophrenia
14 March 2012
The anterior cingulate cortex (ACC) may play a critical role in mediating cognitive deficits in schizophrenia (). The ACC plays a critical role in conflict monitoring (e.g. ) and functional neuroimagi...
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Toshikazu Ikuta,
Philip R. Szeszko,
Patricia Gruner,
Pamela DeRosse,
Juan Gallego,
Anil K. Malhotra
et al.
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267-268
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An autism dimension for schizophrenia in the next diagnostic and statistical manual?
20 February 2012
As the Diagnostic and Statistical Manual for Mental Disorders revision (DSM-Five) task force for schizophrenia moves towards a dimensional approach for capturing symptoms, it is important to consider ...
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Andrea L. Pelletier,
Vijay A. Mittal
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269-270
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