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Masthead
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IFC
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Editorial Board
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Table of Contents
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ii-iii
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Information for Authors
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iv
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In This Issue - June 2012
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v-vi
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| Progress in Pathology |
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Article Title |
Author(s) |
Pages |
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Advances in the pathology of penile carcinomas
Summary: The incidence of penile cancer varies from country to country, with the highest figures reported for countries in Africa, South America, and Asia and lowest in the United States and Europe. C...
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Alcides Chaux,
Antonio L. Cubilla
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771-789
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| Original Contributions |
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Article Title |
Author(s) |
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Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease
31 October 2011
Summary: Nonalcoholic fatty liver disease is a global health dilemma. The gold standard for diagnosis is liver biopsy. Ballooned hepatocytes are histologic manifestations of hepatocellular injury and ...
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Cynthia D. Guy,
Ayako Suzuki,
James L. Burchette,
Elizabeth M. Brunt,
Manal F. Abdelmalek,
Diana Cardona,
Shannon J. McCall,
Aynur Ünalp,
Patricia Belt,
Linda D. Ferrell,
Anna Mae Diehl,
Nonalcoholic Steatohepatitis Clinical Research Network
et al.
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790-800
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c-kit gene mutation and CD117 expression in human anorectal melanomas
12 December 2011
Summary: c-kit and BRAF mutations play an important role during the pathogenesis of melanoma. The subtypes of melanomas arising from different parts of the body have variable c-kit or BRAF mutation fr...
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Shujuan Ni,
Dan Huang,
Xiaochen Chen,
Jiaying Huang,
Yunyi Kong,
Ye Xu,
Xiang Du,
Weiqi Sheng
et al.
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801-807
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E-cadherin nuclear staining is useful for the diagnosis of ovarian adult granulosa cell tumor
14 November 2011
Summary: We recently have demonstrated nuclear localization of E-cadherin in ovarian adult granulosa cell tumors (Histopathology 2011;58:423). The purpose of the present study is to investigate the di...
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Yoshihiro Ohishi,
Shuichi Kurihara,
Tadahisa Takeuchi,
Murasaki Aman,
Tsunehisa Kaku,
Hiroaki Kobayashi,
Norio Wake,
Yoshinao Oda
et al.
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808-817
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Sarcoidosis does not belong to or overlap with immunoglobulin G4–related diseases based on an assessment of serum immunoglobulin G4 levels in cardiac and noncardiac sarcoidosis
02 November 2011
Summary: Although sarcoidosis may exhibit histopathologic features similar to those of a newly emerging clinical entity, immunoglobulin G4–related sclerosing disease, sarcoidosis is currently not cons...
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Fumio Terasaki,
Motomu Tsuji,
Shun Kizawa,
Shuichi Fujita,
Yumiko Kanzaki,
Yasushi Kitaura,
Nobukazu Ishizaka
et al.
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818-825
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Total parenteral nutrition therapy and liver injury: a histopathologic study with clinical correlation
11 November 2011
Summary: Total parenteral nutrition (TPN) therapy is a well-recognized cause of liver injury. The histologic changes attributed to TPN in the literature vary widely. In this study, we describe the his...
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Bita V. Naini,
Charles R. Lassman
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826-833
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Global histone modification of histone H3 in colorectal cancer and its precursor lesions
14 September 2011
Summary: Chromatin remodeling through histone modification is an important mechanism of epigenetic gene dysregulation in human cancers. However, little is known about global alteration of histone stat...
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Tadao Nakazawa,
Tetsuo Kondo,
Defu Ma,
Dongfeng Niu,
Kunio Mochizuki,
Tomonori Kawasaki,
Tetsu Yamane,
Hiroshi Iino,
Hideki Fujii,
Ryohei Katoh
et al.
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834-842
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Expression of endothelin 2 and localized clear cell renal cell carcinoma
02 November 2011
Summary: Despite the rising incidence of clear cell renal cell carcinoma, the molecular events that support its development and progression remain unclear. Herein, we evaluate the association of endot...
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Brian M. Bot,
Jeanette E. Eckel-Passow,
Shauna N. LeGrand,
Tracy Hilton,
John C. Cheville,
Todd Igel,
Alexander S. Parker
et al.
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843-849
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Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell features
07 November 2011
Summary: We recognized immunoreactivity for the α subset of inhibin and synaptophysin in synovial sarcomas with granular cell features. Histologic findings of 90 cases of synovial sarcoma were reviewe...
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Nokitaka Setsu,
Kenichi Kohashi,
Makoto Endo,
Hidetaka Yamamoto,
Yoshihiro Ohishi,
Kazunobu Sueyoshi,
Yukihide Iwamoto,
Masazumi Tsuneyoshi,
Toru Motoi,
Arisa Kumagai,
Yoshinao Oda
et al.
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850-857
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Cyclin kinase subunit 1B nuclear expression predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with bortezomib
02 November 2011
Summary: Amplification of cyclin kinase subunit 1B gene on chromosome 1q21 resulting in overexpression of cyclin kinase subunit 1B has been associated with disease progression in multiple myeloma. Bor...
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Mei-Hsi Chen,
Connie Qi,
Donna Reece,
Hong Chang
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858-864
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Total Survivin and acetylated Survivin correlate with distinct molecular subtypes of breast cancer
07 November 2011
Summary: Global gene expression profiling studies led to the recent classification of breast cancer into 4 distinct molecular subtypes including luminal, human epidermal growth factor receptor 2 enric...
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Evgeny Yakirevich,
Ayman Samkari,
Michael P. Holloway,
Shaolei Lu,
Kamaljeet Singh,
Jovian Yu,
Mary Anne Fenton,
Rachel A. Altura
et al.
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865-873
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Anaplastic thymic carcinoma: a clinicopathologic and immunohistochemical study of 6 cases
07 November 2011
Summary: Primary thymic anaplastic (“undifferentiated”) carcinoma is an unusual thymic neoplasm that, to date, has not been properly characterized. We present 6 such cases in an attempt to better defi...
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Annikka Weissferdt,
Cesar A. Moran
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874-877
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Relationship between alpha-methylacyl–coenzyme A racemase expression and mucin phenotype in gastric cancer
14 November 2011
Summary: Alpha-methylacyl–coenzyme A racemase controls β-oxidation of branched-chain fatty acid and their derivatives. Many investigators have described alpha-methylacyl–coenzyme A racemase expression...
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Yujiro Nozawa,
Ken Nishikura,
Yoichi Ajioka,
Yutaka Aoyagi
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878-887
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High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2
28 December 2011
Summary: Patients on hemodialysis are at higher risk of renal cell carcinoma probably because of inflammatory and immune system disorders. The aim of this study was to clarify the pathologic roles of ...
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Shin-ichi Watanabe,
Yasuyoshi Miyata,
Tomohiro Matsuo,
Yasushi Mochizuki,
Masaharu Nishikido,
Tomayoshi Hayashi,
Hideki Sakai
et al.
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888-897
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Evaluation of the detection of melanin by the Fontana-Masson silver stain in tissue with a wide range of organisms including Cryptococcus
12 December 2011
Summary: It is not uncommon for surgical pathologists to encounter yeast and yeast-like organisms in tissue sections, and correct identification is imperative for guiding therapy. The Fontana-Masson s...
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Justin A. Bishop,
Ann Marie Nelson,
William G. Merz,
Frederic B. Askin,
Stefan Riedel
et al.
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898-903
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Expression of CXCR4 indicates poor prognosis in patients with clear cell carcinoma of the ovary
14 December 2011
Summary: Recent reports have shown that CXCR4 is expressed in various solid tumors and is involved in tumor development and metastasis. We examined the distribution and expression of this molecule in ...
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Ryuichiro Sekiya,
Hiroaki Kajiyama,
Kotaro Sakai,
Tomokazu Umezu,
Mika Mizuno,
Kiyosumi Shibata,
Eiko Yamamoto,
Sawako Fujiwara,
Tetsuro Nagasaka,
Fumitaka Kikkawa
et al.
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904-910
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Pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus
07 November 2011
Summary: The aim of this study was to systematically investigate clinicopathologic features of the recently described pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophag...
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Qin Huang,
Jason S. Gold,
Jiong Shi,
Xiangshan Fan,
Hongyan Wu,
Anning Feng,
Qiang Zhou
et al.
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911-920
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EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis
12 December 2011
Summary: Increased gene copy number (high polysomy or amplification) of EGFR and HER2 has evolved as a predictor for response to targeted therapy. STAT3 and the apoptosis inhibitor survivin represent ...
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Tobias Ettl,
Clemens Stiegler,
Katharina Zeitler,
Abbas Agaimy,
Johannes Zenk,
Torsten E. Reichert,
Martin Gosau,
Thomas Kühnel,
Gero Brockhoff,
Stephan Schwarz
et al.
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921-931
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| Case Studies |
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Unusual thyroid carcinoma with excessive extracellular hyaline globules: a case of “hyalinizing papillary carcinoma”
16 December 2011
Summary: We present an unusual case of papillary thyroid carcinoma in a 47-year-old Japanese woman. The tumor, 0.8 cm in diameter, was located in the upper left lobe of the thyroid. Histologically, we...
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Tetsuo Kondo,
Tadao Nakazawa,
Nobuo Terada,
Kumiko Nakazawa,
Tomonori Kawasaki,
Kunio Mochizuki,
Tetsu Yamane,
Shinichi Ohno,
Ryohei Katoh
et al.
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932-938
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Oral extragonadal yolk sac tumor in a patient with Aicardi syndrome: putative origin and differential diagnosis
06 January 2012
Summary: We report, for the first time, a primary oral presentation of a germ cell yolk sac tumor in a 4-year-old girl with Aicardi syndrome. The diagnosis, differential diagnosis, and histogenesis ar...
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Rhonda Burch-Smith,
Nelson G. Ordonez,
Lawrence E. Ginsberg,
Joann L. Ater,
Adel K. El Naggar
et al.
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939-942
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Diffuse reticuloendothelial system involvement in type IV glycogen storage disease with a novel GBE1 mutation: a case report and review
10 February 2012
Summary: Glycogen storage disease type IV is a rare autosomal recessive disorder of glycogen metabolism caused by mutations in the GBE1 gene that encodes the 1,4-alpha-glucan-branching enzyme 1. Its c...
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Pilar L. Magoulas,
Ayman W. El-Hattab,
Angshumoy Roy,
Deeksha S. Bali,
Milton J. Finegold,
William J. Craigen
et al.
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943-951
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A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst)
27 January 2012
Abstract: Aneurysmal bone cyst is a rapidly growing and locally aggressive lesion that commonly affects children and young adults. Initially regarded as a reactive process, primary aneurysmal bone cys...
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Zenggang Pan,
Warren G. Sanger,
Julia A. Bridge,
William J. Hunter,
Gene P. Siegal,
Shi Wei
et al.
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952-957
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Ectopic hepatic tissue presenting as right atrial mass
25 January 2012
Summary: A 52-year-old woman had a well-circumscribed, mobile mass (1.8 × 1.7 cm) in the right atrium detected by echocardiography and confirmed by magnetic resonance imaging. Subsequent histologic ev...
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Lauren Xu,
Jean Jeudy,
Allen P. Burke
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958-960
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| Correspondence |
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Article Title |
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Ultraviolet radiation resistance-associated polyadenine deletions in human gastric cancer
We read with great interest the results published in Human Pathology by Kim et al . The Authors first described 3 ultraviolet radiation resistance–associated gene (UVRAG) somatic mutations in gastric ...
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Giovanni Corso,
Valeria Pascale,
Daniele Marrelli,
Franco Roviello
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961-962
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| Book Review |
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Article Title |
Author(s) |
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Book review
14 September 2011
As the “master gland” of all endocrine function, there is no doubt that the pituitary requires an exquisite team of worldwide experts to abridge the information available from basic science and clinic...
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Maria Martinez-Lage
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963
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