The purpose of this article is to discuss current standards for preparing nurses to practice as culturally competent generalists in our rapidly shrinking world. Culturally competent care, transcultural nursing practice, and the nursing professions’ standards of nursing care for diverse populations are applied to nursing education, renal nursing, and transplant nursing issues. Recommendations for breaking down health care gaps and barriers include ensuring, within the boundaries and control base of our own practice, that cultural, racial, economic, spiritual, and social diversity is respected and acknowledged.