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Jay N. Cohn New Investigator Award: Basic Science
TLR4-Mediated Signals Converge on the PGC-1 Family of Nuclear Receptor Coactivators to Control Myocardial Metabolism and Function Joel D. Schilling, Teresa Leone, Ling Lai, Nanda Sambandam, Daniel P. Kelly page S1 Full Text | Full-Text PDF (44 KB)
Tetrahydrobiopterin Rescues β3-/- Mice from Cardiac Hypertrophy and Impaired Function Induced by Pressure Overload Jordan S. Leyton-Mange, Xiaulin Niu, Ronghua Yang, Karen L. Miller, An L. Moens, Ashley B. Hale, Djahida Bedja, Kathleen L. Gabrielson, Keith M. Channon, David A. Kass, Lili A. Barouch page S1 Full Text | Full-Text PDF (44 KB)
Modulating Neuregulin/ErbB4 Signaling to Promote Cardiomyocyte Replacement Kevin Bersell, Shima Arab, Bernhard Haring, Bernhard Kuhn page S1 Full Text | Full-Text PDF (44 KB)
Survival and Cardiac Remodeling after Myocardial Infarction Are Critically Dependent on the Host Innate Immune Interleukin-1 Receptor Associated Kinase-4 (IRAK-4) Signaling: A Regulator of Bone Marrow-Derived Dendritic Cells Yuichiro Maekawa, Nobuo Mizue, Annie Chan, Yu Shi, Youan Liu, Chen Manyin, Fayez Dawood, Geoffrey de Coute, Guo Hua Li, Jeffrey A. Medin, Peter P. Liu page S1 Full Text | Full-Text PDF (44 KB)
APJ Receptor Activity Can Be Independent by Its Ligand Apelin Maria Cecilia Scimia, Zhenghong Ling, Rolf Bodmer, Mark Mercola, Pilar Ruiz-Lozano page S2 Full Text | Full-Text PDF (31 KB)
Jay N. Cohn New Investigator Award: Clinical/Integrative Physiology
Prevention of Cardiorenal Fibrosis and Suppression of Proteinuria and Aldosterone Activation Following Experimental Myocardial Infarction with the Novel Natriuretic Peptide CD-NP Fernando L. Martin, S. Jeson Sangaralingham, Paul M. McKie, Brenda K. Huntley, Gerald E. Harders, Horng H. Chen, John C. Burnett page S3 Full Text | Full-Text PDF (74 KB)
Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation: The Distinctive Natural History of Sarcomeric DCM Neal K. Lakdawala, Lisa Dellefave, Elizabeth Sparks, Allison Cirino, Steve Depalma, Birgit Funke, Steven D. Colan, Hugh Watkins, Paul Robinson, Charles S. Redwood, Christine E. Seidman, J.G. Seidman, Elizabeth M. McNally, Carolyn Y. Ho page S3 Full Text | Full-Text PDF (74 KB)
Anti-Remodeling Effects of Chronic Phosphodiesterase-Type-5 Inhibition Are Dependent on Impaired cGMP-Dependent Protein Kinase Signaling Selma F. Mohammed, Josef Korinek, Ahmed D. Abdalrhim, Carolyn S.P. Lam, Robert D. Simari, Horng H. Chen, John C. Burnett, Margaret M. Redfield page S3 Full Text | Full-Text PDF (74 KB)
Suppression of Erythroid Cell Development in Patients with Chronic Heart Failure and Anemia of Unknown Origin: Evidence of an Immune Basis Darlington O. Okonko, Stephen B. Marley, Stefan D. Anker, Myrtle Y. Gordon, Philip A. Poole-Wilson pages S3-S4 Full Text | Full-Text PDF (82 KB)
Malnutrition as Assessed by Nutritional Risk Index Is Associated with Worse Outcome in Patients Admitted with Acute Decompensated Heart Failure Emad Aziz, Eyal Herzog, Amjad Nader, Hari Om Sharma, Sandeep Pulimi, Manpreet Singh, Suchita Mishra, Deborah Tormey, Mina Botross, Marrick Kukin page S4 Full Text | Full-Text PDF (34 KB)
Nursing Research Award
Comparison of the Impact of PHQ-9 Scores with and without Physical Symptom Items on Event-Free Survival in Patients with Heart Failure Kyoung Suk Lee, Terry A. Lennie, Seongkum Heo, Jia-Rong Wu, Misook L. Chung, Debra K. Moser page S5 Full Text | Full-Text PDF (101 KB)
Acute Hemodynamic Effects of Nebulised Furosemide in Stable Heart Failure Phillip J. Newton, Patricia M. Davidson, Henry Krum, Richard Ollerton, Peter Macdonald page S5 Full Text | Full-Text PDF (101 KB)
Against Medical Advice and Improved Heart Failure Care Meriam F. Caboral, Judith E. Mitchell page S5 Full Text | Full-Text PDF (101 KB)
Depressive Symptoms, Poor Nutritional Intake and Event-Free Survival in Patients with Heart Failure: A Deadly Chain of Events Eun Kyeung Song, Debra K. Moser, Heather Payne-Emerson, Seongkum Heo, Sandra B. Dunbar, Susan J. Pressler, Terry A. Lennie pages S5-S6 Full Text | Full-Text PDF (121 KB)
Uncertainty and Emotional Distress in Patients with Heart Failure and Their Primary Caregivers – A Novel Study Karen I. Harkness page S6 Full Text | Full-Text PDF (97 KB)
Oral Presentations: Leading Translational Research
Genetic Deletion of β-Arrestin-1 Improves Function of the Infarcted Heart by Reducing Cardiac β-Adrenergic Receptor Desensitization and Cardiotoxic Neurohormonal Overstimulation Anastasios Lymperopoulos, Giuseppe Rengo, Erhe Gao, Walter J. Koch page S7 Full Text | Full-Text PDF (95 KB)
Cardio-Humoral Actions of the Phosphodiesterase-V Inhibitor Vardenafil in Experimental Diabetic Cardiomyopathy Syed Ameenuddin, Josef Korinek, Elise A. Oehler, S. Jeson Sangaralingham, Fernando L. Martin, Alessandro Cataliotti, John A. Schirger, Horng H. Chen page S7 Full Text | Full-Text PDF (95 KB)
Gene Expression Signature of Non-Ischemic Cardiomyopathy Using an Inflammatory Pathway RNA Array David C. Ishizawar, Karen Hanley-Yanez, Leslie T. Cooper, Jeffrey D. Alexis, Peter P. Liu, Daniel F. Pauly, Richard Sheppard, Dennis M. McNamara page S7 Full Text | Full-Text PDF (95 KB)
Myocyte-Endothelial Cell Cross Talk Involves p38 MAP Kinase Mediated Paracrine Signaling from Cardiomyocytes Beth Rose, Shuxun Ren, Luisa Iruela-Arispe, Yibin Wang pages S7-S8 Full Text | Full-Text PDF (67 KB)
Oral Presentations: Leading Clinical Research
Clinical Validation of a Novel Assay for Galectin-3 for Risk Assessment in Acutely Destabilized Heart Failure R. de Christopher Filippi, Robert Christenson, Ravi Shah, Anju Bhardwaj, James L. Januzzi page S9 Full Text | Full-Text PDF (326 KB)
Neuregulin-1β Is Associated with Cardiomyopathy Etiology, Disease Severity, and Adverse Outcomes in Chronic Heart Failure Bonnie Ky, Stephen E. Kimmel, Radwan N. Safa, Mary E. Putt, Nancy K. Sweitzer, James C. Fang, Douglas B. Sawyer, Thomas P. Cappola page S9 Full Text | Full-Text PDF (326 KB)
G-Protein Coupled Receptor Kinase Expression in Lymphocytes – A Novel Biomarker of Left Ventricular Systolic Function in Heart Failure Patients Raphael E. Bonita, Philip W. Raake, Nicholas J. Otis, Kurt J. Chuprun, Abhijit Dasgupta, Walter J. Koch, Paul J. Mather page S9 Full Text | Full-Text PDF (326 KB)
Severe RV Dysfunction Persists Even after Major Reduction of Volume Status Maryse Palardy, Neal K. Lakdawala, Jose M. Rivero, Mahoto Kato, Patricia Campbell, Carolyn Y. Ho, Michael M. Givertz, Gregory S. Couper, Lynne W. Stevenson pages S9-S10 Full Text | Full-Text PDF (328 KB)
Cardiovascular Physiology
Results of a Pre-Clinical Trial of Periostin Peptide in Myocardial Infarction Dennis Ladage, Yoshiaki Kawase, Scott Shapiro, Mario Garcia, Roger Hajjar, Bernhard Kuhn page S11 Full Text | Full-Text PDF (108 KB)
Effect of Right Ventricular Function on Cardio-Renal Interactions during the Treatment of Decompensated Heart Failure J. Testani, B. McCauley, A. Khera, A. Yu, S. Wiegers, A. Owens, M. St. John Sutton, J. Kirkpatrick page S11 Full Text | Full-Text PDF (108 KB)
Pressure Overload Leads to Severe Concentric Hypertrophy in Adiponectin-Deficient Mice Karen M. O'Shea, David J. Chess, Ramzi J. Khairallah, Kenneth Walsh, William C. Stanley page S11 Full Text | Full-Text PDF (108 KB)
Cardiac-Specific Deletion of Integrin-Linked Kinase Induces Fibrosis, Apoptosis and Cardiomyopathy Jing Dai, Takashi Matsui, E. Dale Abel, Christine E. Seidman, J.G. Seidman, Anthony Rosenzweig pages S11-S12 Full Text | Full-Text PDF (398 KB)
Mild Hypothermia Delays the Evolution of Early LV Dilatation and Late Stone Heart from Untreated Sustained Ventricular Fibrillation Vincent L. Sorrell, Nishant Kalra, Ronald Hilwig, Robert Berg, Karl B. Kern, Gordon A. Ewy page S12 Full Text | Full-Text PDF (345 KB)
Influence of Cardiac Resynchronization Therapy on Cardiac Structural and Electrical Remodeling Steven Eddy, Vince Huebert, Milan Seth, Stephen Ackerman, Michael Chisner page S12 Full Text | Full-Text PDF (345 KB)
Hypoxia, Not the Frequency of Sleep Apnea, Causes Acute Hemodynamic Stress in Patients with Congestive Heart Failure Joshua D. Gottlieb, Alan Schwartz, Samer S. Najjar, Stephen S. Gottlieb pages S12-S13 Full Text | Full-Text PDF (668 KB)
Oral Administration of the Glutathione Peroxidase Mimic SYI-2074 Ameliorates Post-MI Heart Failure in Type 1 Diabetes Mellitus Lyman J. Roberts, Brooke Gliga, ZhiZhang Wang, Michael F. Hill page S13 Full Text | Full-Text PDF (378 KB)
Peak VO2 as a Predictor of Ambulatory Activity of Daily Living in Patients with Chronic Heart Failure Prabhu T. Alahakoon, Alex J. Auseon, Carl V. Leier, Philip F. Binkley page S13 Full Text | Full-Text PDF (378 KB)
Incidence of Severe Isolated Tricuspid Regurgitation (TR) Mimicking the Signs of Constrictive Pericarditis Anitha Rajamanickam, Ali Usmani, Mazen Hanna pages S13-S14 Full Text | Full-Text PDF (726 KB)
Identification of Lin-CD34+/CD38-/CD90+/CD45RA- Progenitors in the Failing Human Heart Asangi R. Kumarapeli, Gwenn Danet-Desnoyers, Andrew D. Bantly, Jonni S. Moore, Kenneth B. Margulies page S14 Full Text | Full-Text PDF (415 KB)
Histologic Correlates of Delayed Enhancement CMR in Ischemic and Nonischemic Heart Failure Omar M. Cheema, Keith Youker, Ankit A. Patel, Ahmad Khalil, Jerry D. Estep, Carlos M. Orrego, Guillermo A. Torre, Dipan J. Shah page S14 Full Text | Full-Text PDF (415 KB)
Regional Right Ventricular Wall Stress and Thickness in Pulmonary Hypertension Chirag A. Chauhan, Derek R. Wisnieski, Christopher R. Deible, Michael A. Mathier, Joan Lacomis, Sanjeev G. Shroff, Michael R. Pinsky, Marc A. Simon pages S14-S15 Full Text | Full-Text PDF (1387 KB)
The Effects of Pulmonary Arterial Hypertension on Left Ventricular Systolic and Diastolic Synchrony Sameer J. Khandhar, Kathy Edelman, Beth Gulyasy, Angel Lopez-Candales page S15 Full Text | Full-Text PDF (1048 KB)
The Prevalence and Characteristics of Chronotropic Incompetence in a General Heart Failure Population: Results from the PEGASUS CRT Trial Stuart D. Russell, John D. Day, Kira Q. Stolen, Stacia Merkel Kraus, Shelly Christman, David O. Martin page S15 Full Text | Full-Text PDF (1048 KB)
Effects of Antihypertensive Medications on Proteolytic Determinants of Myocardial Extracellular Matrix Composition in Patients with Hypertensive Heart Disease S. Mehurg, S. DeSantis, C. Baicu, R. Stroud, S. Thompson, C. McClure, C. Koval, J. Mulcahy, F. Spinale, M. Zile pages S15-S16 Full Text | Full-Text PDF (1357 KB)
LV Lead Repositioning to Apico-Lateral Position in Non Responders to Resynchronization Therapy Improves Patients Acutely and in Long Term Follow Up Dusan Z. Kocovic, Nancy Britton, Mark Heimann, Scott Cox, Steven Rothman page S16 Full Text | Full-Text PDF (379 KB)
Hemodilation Is a Main Cause of Anemia in Patients with Advanced Congestive Heart Failure Dmitry V. Preobrazhensky, Nataliya I. Nekrasova, Irina D. Vyshinskaya, Irina V. Talysina, Talantbek A. Batyraliev page S16 Full Text | Full-Text PDF (379 KB)
Simultaneous Electrical and Mechanical Mapping Using 3D Cardiac Mapping System: Novel Approach for Optimal Cardiac Resynchronization Therapy Kyungmoo Ryu, Andre d'Avila, E. Kevin Heist, Stuart P. Rosenberg, Jessie Chou, Michael Yang, Jagmeet P. Singh pages S16-S17 Full Text | Full-Text PDF (861 KB)
Endothelium-Independent Microvascular Dysfunction Induced by AL Amyloidosis Light Chains in Human Adipose Arterioles: Novel Mechanism of Amyloid Injury Megan Bright, Seth Truran, Brittany Schlundt, David D. Gutterman, Parameswaran Hari, Raymond Q. Migrino page S17 Full Text | Full-Text PDF (549 KB)
Simvastatin Attenuates Endothelial Dysfunction in Human Adipose Arterioles Exposed to AL Amyloid Light Chain Proteins Raymond Q. Migrino, Seth Truran, Brittany Schlundt, Mitchell Timmons, Megan Bright, Parameswaran Hari, David D. Gutterman page S17 Full Text | Full-Text PDF (549 KB)
Hypertension in Heart Failure with Normal LVEF Is Characterized by LVH, Decreased Atrial Ejection Function and Two Distinct Patterns of Abnormal LV Filling M. Rizwan Khalid, Zaruhi V. Babayan, Edward S. Bennett, Fatima R. Khalid, Frank C. Messineo, Icilma V. Fergus pages S17-S18 Full Text | Full-Text PDF (1051 KB)
Reduced Stroke Work Indexed to Left Ventricular Mass Is Associated with Reduced Survival in Patients with Transthyretin (ATTR) Cardiac Amyloidosis Taslima Bhuiyan, Ayan R. Patel, Frederick L. Ruberg, Jeff Packman, Donna Grogan, Mathew Maurer page S18 Full Text | Full-Text PDF (563 KB)
Novel Method of Assessing Left Atrial Systolic Force and Its Quantification in Normal Versus Refractory Heart Failure Patients Sanjay Kumar, Saurabh Kaushik, Richard A. Grimm page S18 Full Text | Full-Text PDF (563 KB)
Developmental Inotropic Sensitivity to Isoproterenol in Developing Zebrafish Hearts In Vivo Hannah L. Semigran, Calum A. MacRae, Jordan T. Shin pages S18-S19 Full Text | Full-Text PDF (1515 KB)
Impact of Longitudinal Cardiac Rotation on Left Ventricular Diastolic Asynergy Chirapa Puntawangkoon, David Verhaert, Bruce Wilkoff, Richard A. Grimm, James D. Thomas, Zoran B. Popovic page S19 Full Text | Full-Text PDF (1006 KB)
Black Bean Extract Inhibits Cardiac Fibrosis and Restores Cardiac Function in an Acute Non-Ischemic Cardiomyopathy Mouse Model Keith A. Youker, Ahmad Khalil, Carlos Orrego, Jose Flores-Arredondo, Sergio Serrano, Jorge Moreno, Guillermo Torre-Amione page S19 Full Text | Full-Text PDF (1006 KB)
Differential Changes in RV and LV Filling Pressures during Acute Decompensation in Chronic Heart Failure Patients Philip B. Adamson, Robert C. Bourge, William T. Abraham, Yong K. Cho, Tom D. Bennett pages S19-S20 Full Text | Full-Text PDF (1166 KB)
Preferential Recruitment of Progenitors Following Myocardial Injury Jeremy A. Elser, Andrew Bantly, Kenneth B. Margulies page S20 Full Text | Full-Text PDF (225 KB)
Pulmonary Artery Systolic Pressure Is an Independent Predictor of Exercise Capacity in Hypertrophic Cardiomyopathy Carolyn S.P. Lam, Paul Sorajja, Steve R. Ommen page S20 Full Text | Full-Text PDF (225 KB)
Predictors and Ramifications of Worsening Renal Function in Acutely Destabilized Heart Failure: Results from the ICON Study Ravi V. Shah, A. Mark Richards, Antoni Bayes-Genis, Yigal Pinto, John Lainchbury, Jordi Ordonez, Roland van Kimmenade, James L. Januzzi pages S20-S21 Full Text | Full-Text PDF (263 KB)
What Predicts Troponin Release in Acutely Decompensated Heart Failure? Ravi V. Shah, A. Mark Richards, Antoni Bayes-Genis, Yigal Pinto, John Lainchbury, Jordi Ordonez, Roland van Kimmenade, James L. Januzzi page S21 Full Text | Full-Text PDF (103 KB)
Administration of Erythropoietin Alfa in Patients with Heart Failure with a Preserved Ejection Fraction (HFPEF) without Elevating Blood Pressure Joseph A. Shatzkes, Sergio L. Teruya, Helen R. Gil, Stephen Helmke, Mathew S. Maurer page S21 Full Text | Full-Text PDF (103 KB)
Intramural Dyssynchrony and Response to CRT in Heart Failure Patients with and without Previous Right Ventricular Pacing Alan J. Bank, Christopher L. Kaufman, Kevin V. Burns, Joshua Parah, Lauren Johnson, Daniel R. Kaiser page S21 Full Text | Full-Text PDF (103 KB)
Ascites Is Not Invariably Present in Heart Failure Patients with Elevated Intra-Abdominal Pressure Poh Shuan Daniel Yeo, Julio A. Barcena, Carmel M. Halley, W.H. Wilson Tang pages S21-S22 Full Text | Full-Text PDF (205 KB)
Impact of Serum Iron Availability on Hemoglobin and Hemdoynamics in Patients with Advanced Heart Failure Micha T. Maeder, David M. Kaye page S22 Full Text | Full-Text PDF (168 KB)
The Xanthine Oxidase Inhibitors Oxypurinol and Allopurinol Reduce Wasting and Improve Cardiac Function in Experimental Cancer Cachexia Jochen Springer, Anika Hartmann, Sandra Palus, Volker Adams, Ruediger von Harsdorf, Stefan D. Anker, Wolfram Doehner page S22 Full Text | Full-Text PDF (168 KB)
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