« Previous
Next »
The Journal of Laboratory and Clinical Medicine
Volume 137, Issue 4
, Pages 231-243
, April 2001
Sarcopenia
References
- . The aging of America: impact on health care costs. JAMA. 1990;263:2335–2340
- . Disability as a public health outcome in the aging population. Annu Rev Public Health. 1996;17:25–46
- . Muscle mass and strength: relation to function in population studies. J Nutr. 1997;127:1004S–1006S
- Appendicular skeletal muscle mass: effects of age, gender and ethnicity. J Appl Physiol. 1997;83:229–239
- . Cross-sectional age differences in body composition in persons 60+ years of age. J Gerontol A Biol Sci Med Sci. 1995;50:M307–M316
- . Human body composition and the epidemiology of chronic disease. Obes Res. 1995;3:73–96
-
.
Assessment of nutritional status in the aged.
In:
Watson RR editors.
Handbook of nutrition in the aged. Boca Raton: : CRC Press; 1994;p. 145–164
-
.
Muscle wasting in the elderly.
Age and Nutrition. 1996;7:96–105
- . Body mass index, weight change, and risk of mobility disability in middle-aged and older women: the Epidemiologic Follow-up Study of NHANES I. JAMA. 1994;271:1093–1098
- . Genetic determinism of fiber-type proportion in human skeletal muscle. Faseb J. 1995;9:1091–1095
- Correlates of impaired function in older women. J Am Geriatr Soc. 1994;42:481–489
-
.
Current population reports, series p-25.
In: Washington, DC: : US GPO; 1986;
-
In:
Garry PJ, Owen GM, Eldridge TO editor.
The New Mexico Aging Process Study. Albuquerque: : University of New Mexico; 1997;
-
.
Epidemiology of sarcopenia in elderly people in New Mexico.
Am J Epidemiol. 1998;147:744–763
- Skeletal muscle mass: evaluation of neutron activation and dual energy X-ray absorptiometry methods. J Appl Physiol. 1996;80:824–831
- . Comparison of techniques to estimate total body skeletal muscle mass in people of different age groups. Am J Physiol. 1999;277:E489–E495
- . Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev. 1999;107:123–126
-
.
Age-related changes in muscle.
Mayo Clin Proc. 2000;75(suppl):S14–S18
- Age and gender comparisons of muscle strength in 654 women and men aged 20-93 years. J Appl Physiol. 1997;83:1581–1587
-
.
Regulation of muscle mass and function: effects of aging and hormones.
In:
Food and Nutrition Board Institute of Medicine editors.
Role of protein and amino acids in sustaining and enhancing performance. Washington, DC: : National Academy Press; 1995;p. 121–136
-
.
Human aging, muscle mass, and fiber type composition [review].
J Gerontol A Biol Sci Med Sci. 1995;50:A11–A16
-
Association of muscle power with functional status in community-dwelling elderly women.
J Gerontol A Biol Sci Med Sci. 2000;55A:M192–M199
- . Muscle performance and structure in the elderly as studied cross-sectionally and longitudinally [review]. J Gerontol A Biol Sci Med Sci. 1995;50A:M17–M22
- . Compensatory muscle fiber hypertrophy in elderly men. J Appl Physiol. 1992;73:812–816
-
.
The effect of age on protein metabolism: current opinion.
Clinical Nutrition and Metabolic Care. 2000;3:39–44
- . Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart. J Biol Chem. 2000;275:3343–3347
-
.
Effect of age on in vivo synthesis rates of mitochondrial protein in human skeletal muscle.
Proc Natl Acad Sci USA. 1996;93:15364–15369
- . Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol. 1997;273:E790–E800
- . Increase in the degree of coexpression of myosin heavy chain isoforms in skeletal muscle fibers of the very old. Muscle Nerve. 1999;22:449–454
- . Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men: a clinical research center study. J Clin Endocrinol Metab. 1996;81:3469–3475
- . Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol. 1995;269:E820–E826
- . Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol. 1995;268:E268–E276
-
.
Myofibrillar protein synthesis in young and old human subjects after three months of progressive resistance training.
Am J Physiol. 1995;268:422–427
- . Motor units in old age. Nature. 1966;209:921–923
- . The effects of ageing upon the human soleus muscle. An electrophysiological study. Medicina. 1976;36:443–451
- . Changes in motor unit estimates with aging. J Clin Neurophysiol. 1996;13:253–260
- . The effect of age on neuromuscular transmission. J Physiol. 1978;274:51–59
- . Skeletal muscle weakness in old age: underlying mechanisms [review]. Med Sci Sports Exerc. 1994;26:432–439
- . Effects of aging on motor-unit control properties. J Neurophysiol. 1999;82:2081–2091
- Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins. Am J Physiol. 1989;256:R659–R665
- . Interleukin-1-induced anorexia in the rat. Influence of prostaglandins. J Clin Invest. 1989;84:228–235
-
Inolvement of interleukin-6 in activation of lysosomal cathepsin and atrophy of muscle fibers induced by intramuscular injection of turpentine oil in mice.
Biochem Biophys Res Commun. 1997;122:595–600
- . The acute metabolic effects of tumor necrosis factor administration in humans. Arch Surg. 1987;122:1396–1400
- . Biological basis for interleukin-1 in disease. Blood. 1996;87:2095–2147
-
.
Human cytokines: their role in disease and therapy.
Cambridge, MA: : Blackwell Science; 1995;
- Rheumatoid cachexia: cytokine-driven hypermetabolism and loss of lean body mass in chronic inflammation. J Clin Invest. 1994;93:2379–2386
- . Standardization of nomenclature of body composition in weight loss. Am J Clin Nutr. 1997;66:192–196
- . Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol A Biol Sci Med Sci. 1998;53A:M20–M26
- IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest. 1998;101:311–320
- . Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood. 1994;83:113–118
- . Anorexia of aging: physiologic and pathologic [review]. Am J Clin Nutr. 1997;66:760–773
- . Neuropeptide regulation of appetite and weight [review]. Endocr Rev. 1987;8:256–287
- . Anorexia and aging: pathophysiology [review]. Nutrition. 1999;15:499–503
- . Inhibition of feeding by a nitric oxide synthase inhibitor: effects of aging. Eur J Pharmacol. 1996;311:15–19
- Relation between postprandial satiation and antral area in normal subjects. Am J Clin Nutr. 1997;66:127–132
- Effects of age on concentrations of plasma cholecystokinin, glucagons-like peptide 1, and peptide YY and their relation to appetite and pyloric motility. Am J Clin Nutr. 1999;69:999–1006
- . Effect of gastrointestinal peptides on ingestion in old and young mice. Peptides. 1988;9:221–225
- Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age. Am J Physiol. 1997;273:R755–R761
-
.
Leptin, adipose tissue and aging: is there a role for testosterone?.
J Gerontol A Biol Sci Med Sci. 1999;54A:B108–B110
- . Evidence for leptin regulation of food intake in humans. J Clin Endocrinol Metab. 1998;83:4382–4385
- . Body composition and age in African-American and caucasian women: relationship to plasma leptin levels. Metabolism. 1997;46:1399–1405
- . Age-related changes in sex hormones affect the sex difference in serum leptin independently of changes in body fat. Metabolism. 1999;48:378–384
- . Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab. 1997;82:1661–1667
- . The effects of aging on opioid modulation of feeding in rats. Life Sci. 1983;32:2793–2799
- . Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats. Brain Res. 1992;575:265–271
-
.
Pathophysiology of catabolism in undernourished elderly patients [review][in German].
Z Gerontol Geriatr. 1999;32S:I12–I19
- . Systemic administration of ciliary neurotrophic factor induces cachexia in rodents. J Clin Invest. 1994;93:2632–2638
- . A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology. 1996;46:1244–1249
- . Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations. Physiol Behav. 1996;60:867–875
- . Wasting in cancer [review]. J Nutr. 1999;129:243S–246S
- . Prevalence and causes of undernutrition in medical outpatients. Am J Med. 1998;104:56–63
- . Causes of weight loss in a community nursing home. J Am Geriatr Soc. 1994;42:583–585
- . Factors associated with low body mass index and weight loss in nursing home residents. J Gerontol A Biol Sci Med Sci. 1995;50A:M162–M168
- . Depression [clinical conference][review]. J Am Geriatr Soc. 1989;37:459–472
- . Anorexia in older persons: epidemiology and optimal treatment [review]. Drugs Aging. 1996;8:134–155
- . Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression [review]. J Affect Disord. 1998;51:267–285
- Benefits of oral protein supplementation in elderly patients with fracture of the proximal femur. J Am Coll Nutr. 1992;11:519–525
-
.
Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture.
A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998;128:801–809
-
Nutritional support and aging in preoperative nutrition [review].
Curr Opin Nutr Metab Care. 1999;2:87–92
- . Does artificial enteral nutrition prolong the survival of institutionalized elders with chewing and swallowing problems?. J Gerontol A Biol Sci Med Sci. 1998;53A:M207–M213
- . Total parenteral nutrition in the critically ill patient: a meta-analysis. JAMA. 1998;280:2013–2019
- . Malnutrition in the elderly. Is it simply a matter of not eating enough [review]?. Postgrad Med. 1996;100:207–208 211-14, 220-2
- . Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. JAMA. 1999;281:1275–1281
-
Evaluation of the effects of oxandrolone on malnourished HIV-positive pediatric patients.
Pediatrics. 1999;104:73
- . Single-agent/combination therapy of human immunodeficiency virus-related wasting [review]. Semin Oncol. 1998;25:98–103
- . Approach to the seriously ill or terminal cancer patient who has a poor appetite. Semin Oncol. 1998;25:33–34
- . Geriatric cachexia: the role of cytokines [review]. Am J Clin Nutr. 1999;70:183–197
- . The effect of recombinant human growth hormone on malnourished older individuals. J Am Geriatr Soc. 1991;39:235–240
- Inceased mortality associated with growth hormone treatment in critically ill adults. N Engl J Med. 1999;341:785–792
-
.
Exercise strategies should be designed to increase muscle power.
J Gerontol. 2000;55A:309–310
- Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991-1994): population reference ranges and contribution of vitamin status to high serum concentrations. Ann Intern Med. 1999;131:331–339
- . Homocysteinemia as a risk factor for atherosclerosis: a review. Cardiovasc Surg. 1997;5:559–567
- Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease. J Vasc Surg. 1998;27:267–274
-
Calf muscle mitochondrial and glycogenolytic ATP synthesis in patients with claudication due to peripheral vascular disease analysed using 31P magnetic resonance spectroscopy.
Clin Sci. 1995;89:581–590
- . Vitamins for the management of cardiovascular disease: a simple solution to a complex problem [review]?. Pharmacotherapy. 1999;19:1400–1414
- . Homocysteine [review]. Crit Rev Clin Lab Sci. 1999;36:365–406
- . Acute creatine supplementation in older men. Int J Sports Med. 2000;21:71–75
- . Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol. 1999;80:139–144
- Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism. 1997;46:410–413
- . Secondary hypogonadism in older men: its relation to impotence. J Clin Endocrinol Metab. 1990;71:963–969
-
Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone.
Proc Natl Acad Sci USA. 1997;94:7537–7542
- . Testosterone and leptin in older African-American men: relationship to age, strength, function, and season. Metabolism. 2000;49:1085–1091
- Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab. 1999;84:2647–2653
- Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc. 1993;41:149–152
- . Effects of testosterone and growth hormone on muscle function [review]. J Lab Clin Med. 1999;134:7–10
-
.
The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women.
Clin Endocrinol. 1998;49:421–432
- . The somatopause: should growth hormone deficiency in older people be treated [review]?. Clin Geriatr Med. 1997;13:671–684
- . Hormonal fountains of youth. J Lab Clin Med. 2000;135:364–366
- Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback. J Clin Endocrinol Metab. 1997;82:2996–3004
-
.
Exercise strategies should be designed to increase muscle power.
J Gerontol A Biol Sci Med Sci. 2000;55A:M309–M310
- A 20-year longitudinal study of Olympic oarsmen. Med Sci Sports Exerc. 1996;28:1150–1156
- . Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures: a randomized controlled trial. JAMA. 1994;272:1909–1914
-
.
A walking program improves gait and balance in nursing home patients.
J Am Geriatr Soc. 1990;28:1267
-
.
A longitudinal trial of weight training in the elderly: continued improvements in year 2.
J Geron A Biol Sci Med Sci. 1996;51A:B425–B433
-
Effects of strength training and detraining on muscle quality: age and gender comparisons.
J Gerontol A Biol Sci Med Sci. 2000;55A:B152–B157
-
.
Changes in power with resistance training in older and younger men and women.
J Gerontol A Biol Sci Med Sci. 1999;54A:M591–M596
-
.
Maximal power across the lifespan.
J Gerontol A Biol Med Sci. 2000;55:M3116
-
Effects of high-intensity resistance training on untrained older men. I. Strength, cardiovascular, and metabolic responses [review].
J Geron A Biol Med Sci. 2000;55A:B336–B346
-
Effects of high-intensity resistance training on untrained older men. II. Muscle fiber characteristics and nucleo-cytoplasmic relationships.
J Gerontol A Biol Med Sci. 2000;55A:B347–B354
- Changes in muscle morphology, electromyographic activity, and force production characteristics during progressive strength training in young and older men. J Gerontol A Biol Sci Med Sci. 1998;53A:B415–B423
-
.
Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men ≥76 yr old.
Am J Physiol. 1999;40:E118–E125
-
.
Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds.
Am J Physiol. 2000;278:E620–E626
- . Self-paced resistance training and walking exercise in community-dwelling older adults: effects on neuromotor performance. J Gerontol A Biol Sci Med Sci. 1997;52A:M161–M168
- Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330:1769–1775
☆ Supported in part by USDA Cooperative Agreement 58-1950-9-001 and National Institutes of Health Grant AG15797. The contents of this publication do not necessarily reflect the views or policies of the US Department of Agriculture, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.
☆☆ Reprint requests: John E. Morley, MB, BCh, Department of Medicine/Geriatrics, Saint Louis University School of Medicine, 1402 South Grand, Room M-238, St Louis, MO 63104.
PII: S0022-2143(01)80110-4
doi: 10.1067/mlc.2001.113504
© 2001 Mosby, Inc. All rights reserved.
« Previous
Next »
The Journal of Laboratory and Clinical Medicine
Volume 137, Issue 4
, Pages 231-243
, April 2001
