Alcohol in pregnancy and neonatal outcome

Abstract

Fetal alcohol syndrome (FAS) and other fetal alcohol effects in children are characterized by life-long compromises in growth, health, behaviour and cognitive ability. Most of the structural signs and many behavioural signs of FAS are evident at birth. This review describes the expression of fetal alcohol effects in neonates, including diagnostic criteria, alcohol withdrawal, pregnancy outcome, growth retardation, facial dysmorphology and behavioural outcomes.

Keywords: alcoholism, brain damage, child behaviour disorders, craniofacial dysostosis, drug-induced abnormalities, fetal alcohol syndrome (FAS), growth disorders, neonatal screening, pregnancy complications, teratogens

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a Department of Obstetrics & Gynecology, Wayne State University School of Medicine, C.S. Mott Center for Human Growth and Development, 275 East Hancock, Detroit, MI, 48201, USA

b Department of Psychology, Wayne State University School of Medicine, C.S. Mott Center for Human Growth and Development, 275 East Hancock, Detroit, MI, 48201, USA

c Department of Anatomy & Cell Biology, Wayne State University School of Medicine, C.S. Mott Center for Human Growth and Development, 275 East Hancock, Detroit, MI, 48201, USA

f1 Corresponce to: D. Randall Armant, Department of Obstetrics and Gynaecology, Wayne State University School of Medicine, C.S. Mott Center for Human Growth and Development, 275 East Hancock, Detroit, MI 48201, USA. E-mail:d.armant@wayne.edu

PII: S1084-2756(00)90027-7

doi:10.1053/siny.2000.0027

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