Transplantation Reviews RSS feed: Articles in Press. Transplantation Reviews contains state-of-the-art review articles on both clinical and experimental transplantation. The journal features invited articles by authorities in immunology, transplantation medicine and surgery.http://www.journals.elsevierhealth.com/periodicals/ytrre//inpress?rss=yesElsevier Inc.en © 2009 Elsevier Inc. All rights reserved. Transplantation Reviews0955-470X2009-10-21 © 2009 Elsevier Inc. All rights reserved. healthpermissions@elsevier.comhttp://www.journals.elsevierhealth.com/periodicals/ytrre/article/PIIS0955470X09001013/abstract?rss=yesAbstract: Secondary lymphoid tissues are the hub of adaptive immune responses wherein rare cognate lymphocytes encounter dendritic cells bearing antigen from peripheral tissues and differentiate into effector and memory cells that eliminate antigen. It is accepted that immune responses against microbial and tumor antigens are initiated within secondary lymphoid tissues. There is less agreement on whether the same principle applies to immune responses to a transplanted organ because an allograft expresses foreign major histocompatibility complex and contains donor antigen presenting cells that could activate T cells directly in situ leading to rejection. Recent studies confirm that although naïve T cells can be primed within the allograft, their differentiation to effect rejection is dependent on secondary lymphoid tissues. Antigen-experienced memory T cells, unlike Naïve T cells, function largely independent of secondary lymphoid tissues to cause allograft rejection. In an alloimmune response, secondary lymphoid tissues support not only immune activation but also immune regulation essential for allograft survival. Here, we will review recent findings and discuss the role of secondary lymphoid tissues in primary and memory alloimmune responses.Role of secondary lymphoid tissues in primary and memory T-cell responses to a transplanted organ - Corrected ProofYue-Harn Ng, Geetha Chalasani10.1016/j.trre.2009.09.003Transplantation Reviews (2009)2009-10-21Transplantation Reviews2009-10-21http://www.journals.elsevierhealth.com/periodicals/ytrre/article/PIIS0955470X09001001/abstract?rss=yesAbstract: Polyomavirus (BK)–associated nephropathy (BKVN) is now recognized as significant problem in pediatric renal transplants that may lead to progressive allograft dysfunction. BKVN was first recognized in 1999 in adult renal transplant recipients, and most data have been obtained from this patient population. Today, there is an increasing number of publications pertaining to children with BKVN that allows for a selective analysis of the pediatric population. Most early pediatric publications were predominantly cases reports. However, several retrospective and prospective studies are now available that provide important insights with respect to the incidence of BKVN in the pediatric transplant population, the efficacy of treatment strategies, and the risk factors for developing BKVN. This review analyzes several of the most significant studies that address these issues.BK virus nephropathy: a pediatric nephrologist's perspective - Corrected ProofLeonard Hymes10.1016/j.trre.2009.09.002Transplantation Reviews (2009)2009-10-19Transplantation Reviews2009-10-19http://www.journals.elsevierhealth.com/periodicals/ytrre/article/PIIS0955470X09000664/abstract?rss=yesAbstract: The success of liver transplantation has led to an ever-increasing demand for liver grafts. Since the first successful living donor liver transplantation, this surgical innovation has been well established in children and has significantly relieved the crisis of donor organ shortage for children. However, the extension of living donor liver transplantation to adult recipients is limited by the graft volume. The major concern of adult-to-adult living donor liver transplantation is the adequate graft that can be harvested from a living donor. Small-for-size graft injury is frequently observed. To develop novel effective treatments attenuating small-for-size liver graft injury during living donor liver transplantation, it is important to explore the precise mechanism of acute phase small-for-size graft damage. Recently, a number of clinical studies and animal experiments have been conducted to investigate the possible key issues on acute phase small-for-size liver graft injury, such as mechanical injury from shear stress, subsequent inflammatory responses, and imbalance of vasoregulatory factors. This review focuses on the mechanism of small-for-size liver graft injury based on the number of clinical and experimental studies. The latest research findings of the significance of acute phase liver graft injury on late phase tumor recurrence and metastasis are also addressed.Small-for-size liver graft injury—impact on tumor behavior - Corrected ProofKendrick Co Shih, Kwan Man10.1016/j.trre.2009.06.004Transplantation Reviews (2009)2009-10-15Transplantation Reviews2009-10-15