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Evaluation of 24-locus MIRU-VNTR in extrapulmonary specimens: Study from a tertiary centre in Mumbai
10 February 2012
Viral Vadwai, Anjali Shetty, Philip Supply, Camilla Rodrigues
Summary: Genotyping of Mycobacterium tuberculosis isolates is a useful tool for epidemiological control of tuberculosis (TB) and phylogenetic exploration of the pathogen. There is a lack of informatio...
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CXCL12 as a biological marker for the diagnosis of tuberculous pleurisy
01 February 2012
Satoshi Kohmo, Takashi Kijima, Masahide Mori, Toshiyuki Minami, Yoshinobu Namba, Yukihiro Yano, Tsutomu Yoneda, Yoshito Takeda, Seigo Kitada, Toshihiko Yamaguchi, Isao Tachibana, Soichiro Yokota
Summary: Although a chemokine CXCL12 is implicated in some infectious diseases, especially those in which T cell-mediated immunity plays critical roles, the relevance of CXCL12 to tuberculosis has nev...
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T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia
09 January 2012
Felipe Riaño, Leonar Arroyo, Sara París, Mauricio Rojas, Annemieke H. Friggen, Krista E. van Meijgaarden, Kees L.M.C. Franken, Tom H.M. Ottenhoff, Luis F. García, Luis F. Barrera
Summary: Mycobacteriumtuberculosis DosR regulon-encoded proteins elicit strong immune T-cell responses in individuals with latent tuberculosis (LTBI). Also, resuscitation (Rpf) proteins can induce suc...
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Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis
06 January 2012
Kajal Buckoreelall, Yanjie Sun, Judith V. Hobrath, Landon Wilson, William B. Parker
Summary: 5′-methylthioadenosine (MTA) is a natural purine that is metabolized by methylthioadenosine phosphorylase (MTAP, E.C 2.4.2.28) in Eukarya and Archaea but generally not in bacteria. In this wo...
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Mycobacterium tuberculosis – Heterogeneity revealed through whole genome sequencing
05 January 2012
Chris Ford, Karina Yusim, Tom Ioerger, Shihai Feng, Michael Chase, Mary Greene, Bette Korber, Sarah Fortune
Summary: The emergence of whole genome sequencing (WGS) technologies as primary research tools has allowed for the detection of genetic diversity in Mycobacterium tuberculosis (Mtb) with unprecedented...
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