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Editorial Board
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| Editorial |
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Tuberculosis and advances in the online delivery of scientific research
Catching a train to work, taking a stroll through the park, or waiting to meet someone in a café, there is no need to be without access to Tuberculosis. These days you can read Tuberculosis and search...
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Ash Allan
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193
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| Review Articles |
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Mycobacterium tuberculosis – Heterogeneity revealed through whole genome sequencing
05 January 2012
Summary: The emergence of whole genome sequencing (WGS) technologies as primary research tools has allowed for the detection of genetic diversity in Mycobacterium tuberculosis (Mtb) with unprecedented...
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Chris Ford,
Karina Yusim,
Tom Ioerger,
Shihai Feng,
Michael Chase,
Mary Greene,
Bette Korber,
Sarah Fortune
et al.
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194-201
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Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload
24 February 2012
Summary: Mycobacterium tuberculosis is an important bacterial pathogen with an extremely slow growth rate, an unusual outer membrane of very low permeability and a cunning ability to survive inside th...
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Jennifer L. Rowland,
Michael Niederweis
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202-210
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| Immunological Aspects |
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A mouse model of tuberculosis reinfection
19 March 2012
Summary: Recent clinical observations shows that individuals treated with chemotherapy for tuberculosis who live in endemic areas are four times more likely to develop secondary disease, often as not ...
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Marcela Henao-Tamayo,
Andrés Obregón-Henao,
Diane J. Ordway,
Shaobin Shang,
Colleen G. Duncan,
Ian M. Orme
et al.
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211-217
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Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation
05 March 2012
Summary: Background: The existence of ectosome-like microvesicles released by neutrophils was proposed a few decades ago. Other studies revealed that the innate immune response during mycobacterial in...
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Tonya Azevedo Duarte,
Alberto Augusto Noronha-Dutra,
Joilda Silva Nery,
Samantha Brum Ribeiro,
Thassila Nogueira Pitanga,
José R. Lapa e Silva,
Sérgio Arruda,
Neio Boéchat
et al.
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218-225
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| Molecular Aspects |
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Characteristics of non-clustered tuberculosis in a low burden country
14 March 2012
Summary: Molecular genotyping studies often focus on clustered tuberculosis and recent transmission. Less attention has been paid to non-clustered tuberculosis. However, non-clustered cases also contr...
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Zaza Kamper-Jørgensen,
Aase Bengaard Andersen,
Axel Kok-Jensen,
Ib Christian Bygbjerg,
Vibeke Ostergaard Thomsen,
Troels Lillebaek
et al.
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226-231
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Dynamic and complex Mycobacterium tuberculosis microevolution unrevealed by standard genotyping
20 February 2012
Summary: We performed an in-depth analysis of a large Mycobacterium tuberculosis cluster involving nine isolates with identical or highly similar RFLP types. The strain involved in this transmission c...
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Laura Pérez-Lago,
Marta Herranz,
Emilio Bouza,
Darío García de Viedma
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232-235
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| Diagnostics |
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Multiplex allele specific PCR for rapid detection of extensively drug resistant tuberculosis
20 February 2012
Summary: Effective tuberculosis (TB) control is hindered by lack of rapid diagnostic tests for detection of drug-resistant TB (DR-TB). Use of molecular tools for rapid detection of multi-and extensive...
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Viral Vadwai,
Anjali Shetty,
Camilla Rodrigues
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236-242
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Anti-phospholipid antibody levels as biomarker for monitoring tuberculosis treatment response
14 March 2012
Summary: Standard methods to monitor tuberculosis (TB) treatment response rely on sputum microscopy and culture conversion. Alternatives to these methods are needed for those patients whose sputum tes...
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Amador Goodridge,
Carla Cueva,
Maureen Lahiff,
Grace Muzanye,
John L. Johnson,
Payam Nahid,
Lee W. Riley
et al.
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243-247
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CXCL12 as a biological marker for the diagnosis of tuberculous pleurisy
01 February 2012
Summary: Although a chemokine CXCL12 is implicated in some infectious diseases, especially those in which T cell-mediated immunity plays critical roles, the relevance of CXCL12 to tuberculosis has nev...
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Satoshi Kohmo,
Takashi Kijima,
Masahide Mori,
Toshiyuki Minami,
Yoshinobu Namba,
Yukihiro Yano,
Tsutomu Yoneda,
Yoshito Takeda,
Seigo Kitada,
Toshihiko Yamaguchi,
Isao Tachibana,
Soichiro Yokota
et al.
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248-252
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| Host Genetics of Susceptibility |
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Genetic variants in antioxidant pathway: Risk factors for hepatotoxicity in tuberculosis patients
17 February 2012
Summary: Tuberculosis (TB) treatment can cause serious sequelae including adverse effects such as anti-TB drug-induced hepatotoxicity (ATDH). We performed a candidate gene-based association study betw...
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Kazutaka Nanashima,
Tsutomu Mawatari,
Naoko Tahara,
Norihide Higuchi,
Ayano Nakaura,
Tatsuo Inamine,
Shinji Kondo,
Katsunori Yanagihara,
Kiyoyasu Fukushima,
Naofumi Suyama,
Shigeru Kohno,
Kazuhiro Tsukamoto
et al.
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253-259
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| Drug Discovery and Resistance |
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Synergistic effect of two combinations of antituberculous drugs against Mycobacterium tuberculosis
20 February 2012
Summary: Fluoroquinolones such as ofloxacin are promising drugs to treat drug-resistant tuberculosis (TB) and have been proposed for shortening the treatment of TB. The objectives were to study the sy...
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Emma Rey-Jurado,
Griselda Tudó,
José Antonio Martínez,
Julian González-Martín
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260-263
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| Epidemiology |
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Evaluation of 24-locus MIRU-VNTR in extrapulmonary specimens: Study from a tertiary centre in Mumbai
10 February 2012
Summary: Genotyping of Mycobacterium tuberculosis isolates is a useful tool for epidemiological control of tuberculosis (TB) and phylogenetic exploration of the pathogen. There is a lack of informatio...
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Viral Vadwai,
Anjali Shetty,
Philip Supply,
Camilla Rodrigues
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264-272
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Identifying multidrug resistant tuberculosis transmission hotspots using routinely collected data
09 March 2012
Summary: In most countries with large drug resistant tuberculosis epidemics, only those cases that are at highest risk of having MDRTB receive a drug sensitivity test (DST) at the time of diagnosis. B...
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Justin Manjourides,
Hsien-Ho Lin,
Sonya Shin,
Caroline Jeffery,
Carmen Contreras,
Janeth Santa Cruz,
Oswaldo Jave,
Martin Yagui,
Luis Asencios,
Marcello Pagano,
Ted Cohen
et al.
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273-279
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| Correspondence |
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Surfactant preparations for tuberculosis and other diseases beyond infancy: A letter from Russia
14 March 2012
Preparations of pulmonary surfactant (Sf) are used for treatment of infant respiratory distress syndrome (RDS). The role of Sf in conditions without its primary deficiency, particularly in lung diseas...
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Sergei V. Jargin
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280-282
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BCG: Myths, realities, and the need for alternative vaccine strategies
20 February 2012
This document is a synopsis of a workshop held on August 2nd, 2011, at the Bill and Melinda Gates Foundation in Seattle, WA. The purpose of the meeting was to re-evaluate exactly what BCG does, what i...
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Helen McShane,
William R. Jacobs,
Paul E. Fine,
Steven G. Reed,
David N. McMurray,
Marcel Behr,
Ann Williams,
Ian M. Orme
et al.
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283-288
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