Tubercle and Lung Disease
Volume 80, Issue 6 , Pages 243-247, December 2000

Deletion of the 19kDa antigen does not alter the protective efficacy of BCG

  • V.V. Yeremeev

      Affiliations

    • Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia
    • ,
  • G.R. Stewart

      Affiliations

    • Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary's Campus, London, UK
    • ,
  • O. Neyrolles

      Affiliations

    • Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary's Campus, London, UK
    • ,
  • K. Skrabal

      Affiliations

    • Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary's Campus, London, UK
    • ,
  • V.G. Avdienko

      Affiliations

    • Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia
    • ,
  • A.S. Apt

      Affiliations

    • Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia
    • ,
  • D.B. Young

      Affiliations

    • Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, St Mary's Campus, London, UK

Accepted 22 September 2000.

Abstract 

Expression of the Mycobacterium tuberculosis 19kDa lipoprotein in saprophytic mycobacteria has been found to reduce their ability to prime a protective response to subsequent virulent challenge in the mouse model. The present study was designed to test whether 19kDa expression has an analogous detrimental effect on the efficacy of BCG vaccination. In contrast to the results in saprophytes, neither overexpression of the 19kDa antigen, nor deletion of the endogenous 19kDa gene altered the ability of BCG to protect against M. tuberculosis challenge in a mouse model.

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  • f1 Correspondence to: Douglas Young, Department of Infectious Diseases and Microbiology, ICSM, St Mary's Campus, Norfolk Place, London W2 1PG, UK. Tel.: +44(0)20 7594 3956; Fax: +44(0)20 7262 6299; E-mail: d.young@ic.ac.uk

PII: S0962-8479(00)90252-1

doi:10.1054/tuld.2000.0252

Tubercle and Lung Disease
Volume 80, Issue 6 , Pages 243-247, December 2000

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